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| 1 | Role of inflammatory response in liver diseases: Therapeutic strategies显示文摘Inflammation and tumorigenesis are tightly linked pathways impacting cancer development. Inflammasomes are key signalling platforms that detect pathogenic microorganisms, including hepatitis C virus(HCV) infection, and sterile stressors(oxidative stress, insulin resistance, lipotoxicity) able to activate pro-inflammatory cytokines interleukin-1β and IL-18. Most of the inflammasome complexes that have been described to date contain a NOD-like receptor sensor molecule. Redox state and autophagy can regulate inflammasome complex and, depending on the conditions, can be either pro-or antiapoptotic. Acute and chronic liver diseases are cytokinedriven diseases as several proinflammatory cytokines(IL-1α, IL-1β, tumor necrosis factor-alpha, and IL-6) are critically involved in inflammation, steatosis, fibrosis, and cancer development. NLRP3 inflammasome gain of function aggravates liver disease, resulting in severe liver fibrosis and highlighting this pathway in the pathogenesis of non-alcoholic fatty liver disease. On the other hand, HCV infection is the primary catalyst for progressive liver disease and development of liver cancer. It is well established that HCV-induced IL-1β production by hepatic macrophages plays a critical and central process that promotes liver inflammation and disease. In this review, we aim to clarify the role of the inflammasome in the aggravation of liver disease, and how selective blockade of this main pathway may be a useful strategy to delay fibrosis progression in liver diseases. | José A Del Campo Paloma Gallego Lourdes Grande | 2018 | World Journal of Hepatology2018，10，1： | 25 |
| 2 | 母猪妊娠期营养对窝产仔猪初生重整齐度的影响显示文摘母猪窝产仔猪初生重整齐度差导致生猪生产效率降低,研究母猪妊娠期间营养需求满足母猪和胎儿营养需要对提高生猪生产效率和增加窝产仔猪初生重的整齐度具有重要意义。然而,母猪妊娠期间营养水平对仔猪初生重整齐度影响的报道很少。本文分析影响仔猪初生重差异的因素及其机制,旨在为寻找提高窝产仔猪整齐度的营养战略提供帮助。 | Campos P H Silva B A Donzele J L 陈琳 龚新明 李君荣 | 2012 | 养猪2012，，5： | 11 |
| 3 | Steatosis and insulin resistance in hepatitis C: A way out for the virus?显示文摘The hepatitis C virus (HCV) induces lipid accumulation in vitro and in vivo. The pathogenesis of steatosis is due to both viral and host factors. Viral steatosis is mostly reported in patients with genotype 3a, whereas meta-bolic steatosis is often associated with genotype 1 and metabolic syndrome. Several molecular mechanisms responsible for steatosis have been associated with the HCV core protein, which is able to induce gene expres-sion and activity of sterol regulatory element binding protein 1 (SREBP1) and peroxisome proliferator-activat-ed receptor γ (PPARγ), increasing the transcription of genes involved in hepatic fatty acid synthesis. Steatosis has been also implicated in viral replication. In infected cells, HCV core protein is targeted to lipid droplets which serve as intracellular storage organelles. These studies have shown that lipid droplets are essential for virus assembly. Thus, HCV promotes steatosis as an eff icient mechanism for stable viral replication. Chronic HCV in-fection can also induce insulin resistance. In patients with HCV, insulin resistance is more strongly associated with viral load than visceral obesity. HCV seems to lead to insulin resistance through interference of intracellular insulin signalling by HCV proteins, mainly, the serine phosphorylation of insulin receptor-1 (IRS-1) and im-pairment of the downstream Akt signalling pathway. The HCV core protein interferes with in vitro insulin signal-ling by genotype-specif ic mechanisms, where the role of suppressor of cytokine signal 7 (SOCS-7) in genotype 3aand mammalian target of rapamycin (mTOR) in geno-type 1 in IRS-1 downregulation play key roles. Steatosis and insulin resistance have been associated with f ibrosis progression and a reduced rate of sustained response to peginterferon plus ribavirin. | José A Del Campo Manuel Romero-Gómez | 2009 | World Journal of Gastroenterology2009，15，40： | 8 |
| 4 | Modulation of faecal metagenome in Crohn's disease:Role of microRNAs as biomarkers显示文摘BACKGROUND The gut microbiota plays a key role in the maintenance of intestinal homeostasis and the development and activation of the host immune system. It has been shown that commensal bacterial species can regulate the expression of host genes. 16 S rRNA gene sequencing has shown that the microbiota in inflammatory bowel disease(IBD) is abnormal and characterized by reduced diversity. Micro RNAs(miRNAs) have been explored as biomarkers and therapeutic targets, since they are able to regulate specific genes associated with Crohn's disease(CD). In this work, we aim to investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.AIM To investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.METHODS Patients attending the outpatient clinics at Valme University Hospital without relevant co-morbidities were matched according to age and gender. Faecal samples of newonset CD patients, free of treatment, and healthy controls were collected. Faecal samples were homogenized, and DNA was amplified by PCR using primers directed to the 16 S bacterial rRNA gene. Pyrosequencing was performed using GS-Junior platform. For sequence analysis, MGRAST server with the database Ribosomal Project was used. MiRNA profile and their relative abundance were analyzed by quantitative PCR.RESULTS Microbial community was characterized using 16 S rRNA gene sequencing in 29 samples(n = 13 CD patients, and n = 16 healthy controls). The mean Shannon diversity was higher in the healthy control population compared to CD group(5.5 vs 3.7). A reduction in Firmicutes and an increase in Bacteroidetes were found. Clostridia class was also significantly reduced in CD. Principal components analysis showed a grouping pattern, identified in most of the subjects in both groups, showing a marked difference between control and CD groups. A functional metabolic study showed that a lower metabolism of carbohydrates(P = 0.000) was found in CD group, while the metabolism of lipids was increased. In CD patients, three miRNAs were induced in affected mucosa: mir-144(6.2 ± 1.3 fold), mir-519(21.8 ± 3.1) and mir-211(2.3 ± 0.4). CONCLUSION Changes in microbial function in active non-treated CD subjects and three miRNAs in affected vs non-affected mucosa have been found. miRNAs profile may serve as a biomarker. | María Rojas-Feria Teresa Romero-García Jose Angel Fernández Caballero-Rico Helena Pastor Ramírez Marta Avilés-Recio Manuel Castro-Fernandez Natalia Chueca Porcuna Manuel Romero-Gomez Federico García Lourdes Grande JoséA Del Campo | 2018 | World Journal of Gastroenterology2018，24，46： | 7 |
| 5 | Key Factors Involved in Lamb Quality from Farm to Fork in Europe显示文摘World lamb consumption is approximately 2 kg per capita with large variations between continents,e.g.,17 kg in Oceania vs.0.7 kg in North America.With less than one million tonnes,the international trade of sheep meat contributes to a small percentage of the total meat exchanged between countries.On the other hand,lamb represents the highest rate of species trading in relation to the total sheep meat produced.It is therefore likely to find a wide variability of different lamb products in the same market,and that the conservation procedures(such as refrigeration,packaging or freezing),chemical composition,especially the fat due to its implication in human health,flavour development and juiciness perception(affected,i.e.,by the feeding or the age or slaughter weight of the animal) and acceptability(based on culinary background) could be considered important indicators of this advantageous situation.In this paper some studies related to the aforementioned indicators are discussed. | Carlos Saudo Erica Muela María del Mar Campo | 2013 | Journal of Integrative Agriculture2013，12，11： | 5 |
| 6 | New insights into the pathophysiology of achalasia and implications for future treatment显示文摘Idiopathic achalasia is an archetype esophageal motor disorder, causing significant impairment of eating ability and reducing quality of life. The pathophysiological underpinnings of this condition are loss of esophageal peristalsis and insufficient relaxation of the lower esophageal sphincter(LES). The clinical manifestations include dysphagia for both solids and liquids, regurgitation of esophageal contents, retrosternal chest pain, cough, aspiration, weight loss and heartburn. Even though idiopathic achalasia was first described more than 300 years ago, researchers are only now beginning to unravel its complex etiology and molecular pathology. The most recent findings indicate an autoimmune component, as suggested by the presence of circulating anti-myenteric plexus autoantibodies, and a genetic predisposition, as suggested by observed correlations with other well-defined genetic syndromes such as Allgrove syndrome and multiple endocrine neoplasia type 2 B syndrome. Viral agents(herpes, varicella zoster) have also been proposed as causative and promoting factors. Unfortunately, the therapeutic approaches available today do not resolve the causes of the disease, and only target the consequential changes to the involved tissues, such as destruction of the LES, rather than restoring or modifying the underlying pathology. New therapies should aim to stop the disease at early stages, thereby preventing the consequential changes from developing and inhibiting permanent damage. This review focuses on the known characteristics of idiopathic achalasia that will help promote understanding its pathogenesis and improve therapeutic management to positively impact the patient's quality of life. | Janette Furuzawa-Carballeda Samuel Torres-Landa Miguel ángel Valdovinos Enrique Coss-Adame Luis A Martín del Campo Gonzalo Torres-Villalobos | 2016 | World Journal of Gastroenterology2016，22，35： | 4 |
| 7 | Colonic duplication in an adult mimicking a tumor of pancreas显示文摘Duplications of the alimentary tract are uncommon congenital malformations that can present diagnostic difficulties. We report a rare case of a cystic colonic duplication in a female adult. Preoperative investigations were suggestive of pancreatic tumor. The diagnosis was established based on the histopathological examination of the resected specimen. We concluded that, though uncommon, intestinal duplication should be considered in differential diagnosis of abdominal mass. | Fabiana Pirani Carneiro Maria de Nazareth Sobreira Ana Emília B de Azevedo Andréa Pedrosa Ribeiro Alves Karina Martins Campos | 2008 | World Journal of Gastroenterology2008，14，6： | 3 |
| 8 | Modulation of host lipid metabolism by hepatitis C virus: role of new therapies显示文摘It is well established that hepatitis C virus(HCV) infection and replication relies on host lipid metabolism. HCV proteins interact and associate with lipid droplets to facilitate virion assembly and production. Besides,circulating infective particles are associated with verylow-density lipoprotein. On the other hand,higher serum lipid levels have been associated with sustained viral response to pegylated interferon and ribavirin therapy in chronic HCV infection,suggesting a relevant role in viral clearance for host proteins. Host and viral genetic factors play an essential role in chronic infection. Lipid metabolism is hijacked by viral infection and could determine the success of viral replication. Recently development of direct acting antiviral agents has shown a very high efficacy(> 90%) in sustained viral response rates even for cirrhotic patients and most of the viral genotypes. HCV RNA clearance induced by Sofosbuvir has been associated with an increased concentration and size of the low-density lipoprotein particles. In this review,host genetic factors,viral factors and the interaction between them will be depicted to clarify the major issues involved in viral infection and lipid metabolism. | José A Del Campo Manuel Romero-Gómez | 2015 | World Journal of Gastroenterology2015，21，38： | 2 |
| 9 | Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium boris BCG显示文摘 | Dillon DC Alderson MR Day CH Bement T Campos Neto A Skeiky YA Vedvick T Badaro R Reed SG Houghton R | 2000 | J Clin Microbiol2000，38，9： | 1 |
| 10 | Cytidin-5-diphosphocholine enhances the effect of part-time occlusion in amblyopia 显示文摘 | Bolzani R Schiavi C Baldi A Porciatti V | 1996 | Doc Ophthalmol1996，93，3： | 1 |
| 11 | Comparing paymentvehicle effects in contingent valuation studies for recreational use in two protected spanish forests显示文摘 | Campos P Caparros A Oviedo J L | 2007 | Journal of Leisure Research2007，，39： | 1 |
| 12 | Stabilityof the ANAMMOX process in a gas - lift reactor and a SBR 显示文摘 | Dapena - Mora A Campos J L Mosquera - Corral A | 2004 | journal of Biotechnology2004，110，2： | 1 |
| 13 | Chronic hepatitis induced by Jin Bu Huan显示文摘 | Picciotto A Campo N Brizzolara R | 1998 | J Hepatol1998，28，： | 1 |
| 14 | Targeting and topology in the membrane of plant 3-hydroxy-3-methylglutaryl coen- zyme A reductase显示文摘 | Campos N Boronat A | 1995 | Plant Cell1995，7，12： | 1 |
| 15 | Simultaneous methanogenesis and denitrification of pretreated effluents from a fish canning industry 显示文摘 | Mosquera-Corral A Campos J L Sanchez M | 2001 | Water Research2001，35，2： | 1 |
| 16 | Bowel injury in gynecologic laparoscopy显示文摘 | Brosens I Gordon A Campo R | 2003 | J Am Assoc Gynecol Laparosc2003，10，1： | 1 |
| 17 | Thermal investi- gation of uncased and cased tobacco 显示文摘 | Longanezi T Campos M P A Moth6 C G | 2002 | Thermochim Ac- ta2002，39，： | 1 |
| 18 | Expression of mitochondrial non- coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes显示文摘 | VILLOTA C CAMPOS A VIDAURRE S | 2012 | J Biol Chem2012，287，21： | 1 |
| 19 | Screw fixation of the syndesmosis:a cadaver model comparing stainless steel and titanium screws and three and four cortical fixation 显示文摘 | Beumer A Campo MM Niesing R | 2005 | Injury2005，36，1： | 1 |
| 20 | Incidence of endophthalmitis and impact of prophylaxis with cefu- roxime on cataract surgery 显示文摘 | RODRIGUEZ-CARAVACA G GARCIA-SAENZ MC VILLAR-DEL- CAMPO MC ANDRIES-ALBA Y ARIAS PIJENTE A | 2013 | J Cataract Refract Surg2013，39，9： | 1 |
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