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| 1 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 2 | 显示文摘 | Camellia P Wuled L Kikuo O | 2003 | J Nanoparticle Research2003，5，： | 1 |
| 3 | Nacturral catecholamires and immure function in insomniacs,depressed patients,and control subjects显示文摘 | Michael L Camellia KJHK Brian K | 2003 | Brain behavior and Immunity2003，17，： | 1 |
| 4 | Determination of captopril in human serum by high performance liquid chromatography using solid-phase extraction显示文摘 | MANOOCHEHR B AZARM K CAMELLIA | 1997 | J Pharm Biomed Anal1997，15，： | 1 |
| 5 | Kuntze and associated biochemical changes 显示文摘 | Rout G~ Effect of auxins on adventitious root development from single node cuttings of Camellia sinensis L | 2006 | Plant Growth Regulation2006，，48： | 1 |
| 6 | Polymer-supported solution synthesis of blue luminescent BaMgAl10017 : Eu^2+ particles显示文摘 | Camellia Panatarani Wuled Lenggoro I Naoki hoh | 2005 | Mater Sci Eng B2005，122，3： | 1 |
| 7 | Growing camellias in cold climates 显示文摘 | American Camellia Society | 1998 | Camellia Yearbook1998，42，： | 1 |
| 8 | Synthesis of single crystalline ZnO nanoparticles by salt-assisted spray pyrolysis显示文摘 | CAMELLIA PANATRANI I WULED LENGGORO KIKUO OKUYAMA | 2003 | Journal of Nanoparticles Research2003，5，： | 1 |
| 9 | Synthesis of single crystalline ZnO nanoparticles by salt-assisted spray pyrolysis显示文摘 | Camellia Panatarani I Wuled Lenggoro Kikuo Okuyama | 2003 | Journal of Nanoparticle Research2003，5，： | 1 |
| 10 | Synthesis of single crystalline ZnO nanoparticles by salt-assisted spray pyrolysis显示文摘 | Camellia Panatarani Wuled Lenggoro Kikuo Okuyama | 2003 | Journal of Nanoparticle Research2003，5，： | 1 |
| 11 | 意大利童话新唱显示文摘从北京到马来西亚再到意大利,原本此生都不会有交集的两个人,却因美食结缘,千里迢迢地相遇在这个仿佛只存在于宫崎骏动画片里的童话小镇。在这个嫁到意北的马来西亚女子厨房里,我体会到了原来世上真的有奇迹存在。 | Camellia | 2010 | 世界2010，，10： | 0 |
| 12 | 脑洞×无限大显示文摘深蓝的夜空是茫茫海洋,
轻飘飘的流云化身为迷路的鲸鱼,
兔子先生嘟着嘴,
问回家的路在哪里。 | Camellia 狐狸飞 | 2017 | 小葵花(故事画刊)2017，0，11： | 0 |
| 13 | Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement显示文摘The low solubility of ethyl p-methoxycinnamate(EPMC)inhibits its absorption in the gastrointestinal tract,impairing its pharmacological effect.The solubility of EPMC can be increased by utilizing a carrier in the type of mesoporous silica nanoparticles(MSN).In the present study,we aimed to confine EPMC under the nanoscale of MSN(MSN-EPMC)to increase the water solubility of EPMC.MSN was prepared using sodium silica as a precursor and Tween 80 and Span 80 as templates.Briefly,500 mg MSN was dispersed into 2%w/v EPMC solution,stirred at 100 r/min for 24 h,and dried at 60℃.The results showed that the MSN formed had a particle size of 87.1305 nm,a surface area of 68.86 m;/g,a pore diameter of 20.45 nm,and a pore volume of 0.352 cm;/g.EPMC was successfully confined under the nanoscale of MSN.MSN-EPMC had an amorphous structure,a loading capacity of 10.6%,and a loading efficiency of 18.18%.The solubility of MSN-EPMC was increased by 2.63 folds at 30 min compared with EPMC.The amorphous structure of MSN-EPMC was responsible for the enhancement of the water solubility.It could be concluded that the confining of EPMC in MSN had the potential to increase the solubility of a water-soluble isolate of a plant. | Revika Rachmaniar Dolih Gozali Camellia Panatarani Wahyu Priyo Legowo Sohadi Warya Taofik Rusdiana | 2022 | Journal of Chinese Pharmaceutical Sciences2022，31，6： | 0 |
| 14 | 浮迹浪踪 终须相逢——设计“祝融号”火星车模型显示文摘红色星球火星荧荧,浮迹浪踪。火星主要由岩石构成,由于含有大量的铁元素,被氧化后,表面呈铁锈般的红色,故被称为“红色星球”。图1、图2所示为中国国家航天局拍摄的火星照片。火星的体积大约只有地球的15%,但火星上的一年约有687个地球日(公转周期为687个地球日). | Camellia Café | 2021 | 无线电2021，，8： | 0 |
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