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| 1 | MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。 | Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt | 2018 | Cell Research2018，28，7： | 5 |
| 2 | Pesticide residues in cashew apple, guava, kaki and peach: GC–μECD, GC–FPD and LC–MS/MS multiresidue method validation, analysis and cumulative acute risk assessment显示文摘 | Andréia Nunes Oliveira Jardim Denise Carvalho Mello Fernanda Caroline Silva Goes Elcio Ferreira Frota Eloisa Dutra Caldas | 2014 | Food Chemistry2014，，： | 2 |
| 3 | Sudden Changes in Chaotic Attractors and Transient Basins in a Model for Rattling in Gearboxes显示文摘 | de Souza S L T Caldas I L Viana R L | 2004 | Chaos Solitons and Fractals2004，21，3： | 1 |
| 4 | Frequent somatic mutations and homozygous of the P16(MTS1) gene in pancreatic adenocarcinoma显示文摘 | Hahn SA da Costa LT | 1994 | Nat Genet1994，8，： | 1 |
| 5 | Hypertrophic Cranial Pachymeningitis and Skull Base Osteomyelitis by Pseudomonas Aeruginosa: Case Report and Review of the Literature显示文摘 | Ana Rita Caldas Mariana Brandao Filipe Seguro Paula Elsa Castro Fatima Farinha Antonio Marinho | 2012 | Journal of Clinical Medicine Research2012，，2： | 1 |
| 6 | Dural arteriovenous fistula and tinnitus: case report显示文摘 | CALDAS S ALCOFORADO A CALDAS N | 2004 | Otolaryngol Head Neck Surg2004，131，： | 1 |
| 7 | New formula to objectively evaluate skeletal maturation using lateral cephalometric radiographs显示文摘 | Caldas Mde P Ambrosano GM Haiter Neto F | 2007 | Braz Oral Res2007，21，4： | 1 |
| 8 | Electromyographic activity in patients with temporomandibular disorders 显示文摘 | Pinho JC Caldas FM Moral M J | 2000 | J Oral Rehabil2000，27，11： | 1 |
| 9 | Fiberoptic hot-wire flowmeter based on a metallic coated hybrid long period grating/fiber Bragg grating structure显示文摘 | Caldas P Jorge P A S Rego G | 2011 | Applied Optics2011，50，17： | 1 |
| 10 | Chaperone properties of the bacterial periplasmic substrate-binding proteins显示文摘 | Richarme G Caldas TD | 1997 | J Biol Chem1997，272，15： | 1 |
| 11 | Viscosity of water-in-oil emulsions: Variation with temperature and water volume fraction显示文摘 | FARAH M A OLIVEJRA R C CALDAS J N | 2005 | Journal of Petroleum Science and Engineering2005，48，： | 1 |
| 12 | Effect of soil moisture and fertilization on Perola pineapple in Coastal Tableland areas of Brazil 显示文摘 | Souza L F D de Almeida O A Caldas R C | 2002 | Tropical Agriculture2002，79，2： | 1 |
| 13 | MicroRNA—implications for cancer显示文摘 | Stefanie Sassen Eric A. Miska Carlos Caldas | 2008 | Virchows Archiv2008，，1： | 1 |
| 14 | Somatic mutation in the p53 gene and prognosis in beast cancer A meta-analysis显示文摘 | Pharoah PD Day NE Caldas C | 1999 | Br J Cancer1999，80，12： | 1 |
| 15 | Sizing up miRNAs as cancer genes 显示文摘 | Caldas C Brenton JD | 2005 | Nat Med2005，11，3： | 1 |
| 16 | Sizing up miRNA as cancergenes显示文摘 | Caldas C Brenton JD | 2005 | Naure Med2005，11，7： | 1 |
| 17 | E-cadherin mutations and hereditary gastric cancer: prevention by resection?显示文摘 | FITZGERALD R C CALDAS C | 2002 | Dig Dis2002，20，1： | 1 |
| 18 | Chaperone properties of bacterial elongation factor EF-Tu显示文摘 | Caldas T D Yaagoubi A El Richarme G | | 0，，19： | 1 |
| 19 | Simultaneous determination of pesticides and 5-hydroxymethylfurfural in honey by the modified QuEChERS method and liquid chromatography coupled to tandem mass spectrometry显示文摘 | Débora Tomasini Maicon R.F. Sampaio Sergiane S. Caldas Jaqueline G. Buffon Fábio A. Duarte Ednei G. Primel | 2012 | Talanta2012，，： | 1 |
| 20 | Left Atrial Function After Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Ana Clara Tude Rodrigues Mauricio I. Scannavacca Márcia Azevedo Caldas Viviane Tiemi Hotta Cristiano Pisani Eduardo A. Sosa Wilson Mathias | 2009 | The American Journal of Cardiology2009，，3： | 1 |
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