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| 1 | CaMKIIα-driven,phosphatase-checked postsynaptic plasticity via phase separation显示文摘Ca^(2+)/calmodulin-dependent kinase Ila(CaMKIla)is essential for synaptic plasticity and learning by decoding synaptic Ca^(2+)oscillations.Despite decades of extensive research,new mechanisms underlying CaMKIIa's function in synapses are still being discovered.Here,we discover that Shank3 is a specific binding partner for autoinhibited CaMKIla.We demonstrate that Shank3 and GluN2B,via combined actions of Ca^(2+)and phosphatases,reciprocally bind to CaMKIla.Under basal condition,CaMKIla is recruited to the Shank3 subcompartment of postsynaptic density(PSD)via phase separation.Rise of Ca^(2+)concentration induces GluN2Bmediated recruitment of active CaMKIla and formation of the CaMKIIa/GluN2B/PSD-95 condensates,which are autonomously dispersed upon Ca^(2+)removal.Protein phosphatases control the Ca^(2+)-dependent shuttling of CaMKIla between the two PSD subcompartme nts and PSD condensate formation.Activation of CaMKIla further enlarges the PSD assembly and in duces structural LTP.Thus,Ca^(2+)-induced and phosphatase-checked shuttling of CaMKIla between distinct PSD nano-domains can regulate phase separation-mediated PSD assembly and synaptic plasticity. | Qixu Caic Menglong Zeng Xiandeng Wu Haowei Wu Yumeng Zhan Ruijun Tian Mingjie Zhang | 2021 | Cell Research2021，31，1： | 3 |
| 2 | Effect of approach span condition on vehicle-induced dynamic response of slab-on-girder road bridges显示文摘 | CAIC S SHI X M ARAUJO M | 2007 | Engi- neering Structures2007，29，12： | 1 |
| 3 | Androgen induces expression of the multi drug resistance protein gene MRP4 in prostate cancer cells 显示文摘 | CaiC Omwancha 1 Hsieh CL | 2007 | Prostate Cancer Prostatic Dis2007，10，1： | 1 |
| 4 | Establishment of regeneration system from leaves of 3 Populus varieties(3个杨树品种叶片再生体系的建立)[J]显示文摘 | SHENZG(沈周高) XIANGY(项艳) CAIC(蔡诚) etal | | 林业科学0，，： | 1 |
| 5 | SVM-Prot: Web -Based Support Vector Machine Software for Functional Classification of a Protein from Its Primary Sequence显示文摘 | CAIC Z HAN L Y JI Z L etal | 2003 | Nucleic Acids Res2003，31，13： | 1 |
| 6 | Function prediction for DNA-/RNA-binding proteins, GPCRs, and drug ADME-associated proteins by SVM显示文摘 | CAIC Z XIAO H G YUAN Q F | 2008 | Protein & Peptide Letters2008，15，5： | 1 |
| 7 | Lowtemperaturecondi-tioningreducespostharvestchillinginjuryinloquatfruit显示文摘 | CAIC XUC SHANL etal | 2006 | PostharvestBiolTec2006，41，3： | 1 |
| 8 | MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells显示文摘 | Wu L CaiC Wang X | 2011 | FEBS letters2011，585，9： | 1 |
| 9 | A novel technology for powder dispersion and surface modification显示文摘 | CAIC J SHEN Z G ZHENG Y H | 2007 | J Materials Science2007，11，42： | 1 |
| 10 | Iodine catalysis in aqueous medium:An improved reaction system for Knoevenagel and Nitroaldol condensation显示文摘 | RENY M CAIC | | 0，，1： | 1 |
| 11 | Flutter and BuffetingAnalysis I: Finite-element and RPE Solution 显示文摘 | CAICS ALBRECHT P BOSCH H R | 1999 | Journal ofBridge Engineering1999，4，3： | 1 |
| 12 | 钢一缩口型压型钢板混凝土组合梁试验研究显示文摘 | 唐亮 聂建国 CAIcs | 2005 | 哈尔滨工业大学学报2005，37，： | 1 |
| 13 | MicroRNA-142-3p,a new regulator of RAC1,suppresses the migration and invasion of hepatocellular carcinoma cells显示文摘 | WuL CaiC WangX | | 0，，9： | 1 |
| 14 | 传统“三位一体”经济体制的形成及市场化取向改革突破口的选择显示文摘中国传统经济体制的逻辑起点是重工业优先发展战略。由于重工业资本密集的特征与当时中国资本稀缺的资源禀赋状况形成矛盾,不可能依靠市场机制配置资源而推动重工业优先发展,因此就需要由政府出面,人为压低利率、汇率、能源和原材料价格及工资和生活必需品价格,以便降低重工业发展的成本,从而形成“三位一体”的经济体制:扭曲的宏观政策环境、高度集中的资源计划配置和毫无自主权的微观经营机制。本文对传统经济体制形成过程进行分析,以便对我国改革开放以来市场化取向突破口选择有更加深刻的认识。 | Gao Jianbin (Department of Social Sciences CAIC, Tianjin 300300) | 1998 | 中国民航学院学报1998，16，2： | 0 |
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