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| 1 | Occurrence and fate of endogenous steroid hormones,alkylphenol ethoxylates, bisphenol A and phthalates in municipal sewage treatment systems显示文摘Steroid hormones, alkylphenol ethoxylates(APEOs) and phthalic acid esters(PAEs) are emerging endocrine disrupting chemicals(EDCs) that can interfere with the endocrine function in organisms at low concentrations. The occurrence, distribution behavior, removal rate and the fate of 31 target EDCs in sewage treatment plants, which consist of various treatment facilities and receiving water in Hong Kong, were investigated. Estrone,nonylphenol-di-ethoxylate and diethyl phthalate were found to be dominant in each group of influent samples with concentrations ranging from 11–33, 747–3945 and 445–4635 ng/L,respectively. Conversely, progesterone, nonylphenol-mono-ethoxylate and bis(2-ethylhexyl)phthalate were the most abundant in dewatered sludge, with concentrations ranging from 0.9–237, 75–19,743 and 4310–37,016 ng/g(dry weight). The removal rates of primary sedimentation and disinfection approaches were lower than 30% for most of the chemicals,while those of activated sludge and reverse osmosis were greater than 80% for more than two-thirds of the compounds, noticeably decreasing the estrogenic risk of sewage discharged into the environment. Steroid hormones were removed via biological degradation, while some APEOs and PAEs adsorbed to the sludge. Victoria Harbor poses a low to medium estrogenic risk mainly contributed by estrone and estradiol and deserves attention. | Qian Wu James C.W.Lam Karen Y.Kwok Mirabelle M.P.Tsui Paul K.S.Lam | 2017 | Journal of Environmental Sciences2017，29，11： | 10 |
| 2 | 香港结核病与吸烟调查显示文摘目的:了解在香港人群中吸烟与结核病的联系。方法:利用间接调整法比较1996年报告登记的851例结核病人样本与一般人群的吸烟率。并利用分层单因素分析和多元logisitc回归分析方法比较了曾吸烟者与不吸烟者的临床特征。结果:与人群对照相比,结核病人的吸烟率较高。在16-64岁组,吸烟与结核病之间的比值比(OR)在男性和女性分别为2.44和2.08(Mantel-Haenszel加权OR=2.40,P<0.001);在65岁以上组,则分别为 2.09和2.83(Mantel-Haenszel加权 OR=2.19,P<0.001)。男性、65岁以上、发病时仍在工作、经 常饮酒、吸毒以及无结核病接触史等与吸烟有关(P<0.05)。曾吸烟者的咳嗽比例高(OR=1.69)、容易憋气(OR=1.84)、上肺区受累多(OR=1.67)、易发空洞(OR=1.76)和粟粒性肺结核(OR=2.77)以及痰菌培养阳性的概率较大(OR=1.43),但发生孤立肺外结核病的机会要小(OR=0.31),即使控制了背景因素的混杂作用后也如此(P<0.05)。结论:吸烟与结核病有关。严重类型的肺结核多见于曾吸烟者。 | C.C.Leung C.K.Chan C.M.Tam K.C.Chang C.H.Chau W.S.Law W.W.Yew C.H.Chau C.W.Lam K.S.Lau 贺晓新 | 2003 | 国际结核病与肺部疾病杂志2003，，4： | 5 |
| 3 | Sea Nine 211 as antifouling biocide: A coastal pollutant of emerging concern显示文摘Sea Nine 211, with 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one(DCOIT) being the biocidal ingredient, is a widely-used antifouling agent to deter the undesirable biofouling phenomenon. It is commercially promoted as an environmentally acceptable antifoulant mainly due to its claimed rapid degradation in marine environment. However, increasing researches document varying degradative kinetics in different environments, proving that Sea Nine 211 is actually not degraded equally fast around the world(half-life between< 1 day and 13.1 days). Large-scale application of Sea Nine 211 in antifouling coatings has also caused global contamination of marine environment in various compartments. For example, accumulation of Sea Nine 211 is detected as high as 3700 ng/L in Spanish seawater and 281 ng/g dry weight in Korean sediment. Considering that Sea Nine 211 is highly toxic against non-target marine organisms, environmental risk assessment finds that most marine organisms are endangered by Sea Nine 211 in worst-case scenario. Its endocrine disrupting and reproductive impairing effects at environmentally worst-case concentrations further constitute a long-term threat to the maintenance of population stability.Therefore, in the light of the varying degradability, environmental pollution and high toxicity, especially the endocrine disruption, Sea Nine 211 as an antifouling agent is likely to cause non-negligible damages to the marine ecosystem. There is an urgency to perform a systematic ecological risk assessment of Sea Nine 211 to prevent the potential impacts on the health of marine environment. A regular monitoring also becomes necessary to place the usage of antifouling biocides under control. | Lianguo Chen James C.W.Lam | 2017 | Journal of Environmental Sciences2017，29，11： | 3 |
| 4 | 中国利福喷丁在香港临床研究期间的生物利用度显示文摘背景:利福喷丁在香港的临床研究。目的:评价研究中所使用的中国利福喷丁的生物利用度。设计:通过微生物学试验测定给予四批药物的287名病人血清标本中利福喷丁的含量结果:从40名病人中随机分配给西方或中国的利福喷丁所获得的首批曲线区域图对比显示:中国利福喷丁生物利用度是西方药物的74%。第二批药的生物利用度发现是西方的66%,最后二批利福喷丁的剂量由计划的600mg增至750mg或短时增至900mg,则血清中浓度同西方药获得的相类似,在每批药使用期间生物利用度没有变化。结论:通过比较开始二批和最后二批试验的结果将估价利福喷丁剂量对疗效和毒性的作用。 | C.M.Tam S.L.Chan C.W.Lam J.M.Dickinson D.A.Mitchison 屠德华 | 1998 | 国际结核病与肺部疾病杂志1998，，1： | 1 |
| 5 | Procalcitonin fails to differentiate inflammatory status or predict long-term outcomes in peritoneal dialysis-associated peritonitis显示文摘 | Lam M.F J.C.Leung C.W.Lam | | 0，，： | 1 |
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