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4篇 您的检索式:作者名="C.Holmes"
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1Viral respiratory infections among Hajj pilgrims in 2013显示文摘Middle East respiratory syndrome coronavirus(MERS-Co V) has emerged in the Arabian Gulf region, with its epicentre in Saudi Arabia, the host of the ‘Hajj' which is the world's the largest mass gathering. Transmission of MERS-Co V at such an event could lead to its rapid worldwide dissemination. Therefore, we studied the frequency of viruses causing influenza-like illnesses(ILI) among participants in a randomised controlled trial at the Hajj 2013. We recruited 1038 pilgrims from Saudi Arabia, Australia and Qatar during the first day of Hajj and followed them closely for four days. A nasal swab was collected from each pilgrim who developed ILI. Respiratory viruses were detected using multiplex RT-PCR. ILI occurred in 112/1038(11%) pilgrims. Their mean age was 35 years, 49(44%) were male and 35(31%) had received the influenza vaccine pre-Hajj. Forty two(38%) pilgrims had laboratory-confirmed viral infections; 28(25%) rhinovirus, 5(4%) influenza A, 2(2%) adenovirus, 2(2%) human coronavirus OC43/229 E, 2(2%) parainfluenza virus 3, 1(1%) parainfluenza virus 1, and 2(2%) dual infections. No MERS-Co V was detected in any sample. Rhinovirus was the commonest cause of ILI among Hajj pilgrims in 2013. Infection control and appropriate vaccination are necessary to prevent transmission of respiratory viruses at Hajj and other mass gatherings.Osamah Barasheed Harunor Rashid Mohammad Alfelali Mohamed Tashani Mohammad Azeem Hamid Bokhary Nadeen Kalantan Jamil Samkari Leon Heron Jen Kok Janette Taylor Haitham El Bashir Ziad A.Memish Elizabeth Haworth Edward C.Holmes Dominic E Dwyer Atif Asghar Robert Booy 2014Virologica Sinica2014,29,6:3
2Generation of a triple‐gene knockout mammalian cell line using engineered zinc‐finger nucleases显示文摘Pei‐QiLiu Edmond M.Chan Gregory J.Cost LinZhang JianbinWang Jeffrey C.Miller Dmitry Y.Guschin AndreasReik Michael C.Holmes John E.Mott Trevor N.Collingwood Philip D.Gregory 2010Biotechnol Bioeng2010,,1:1
3Host species barriers to influenza virus infections显示文摘Thijs Kuiken Edward C.Holmes John McCauley 0,,5772:1
4Identification of bovine coronavirus in a Daurian ground squirrel expands the host range of Betacoronavirus 1显示文摘Dear Editor,Bovine coronavirus(BCoV)is a member of the species Betacoronavirus 1 in the genus Betacoronavirus,subgenus Embecovirus.Other members of the species Betacoronavirus 1 comprise porcine hemagglutinating encephalomyelitis virus(PHEV),human coronavirus OC43(HCoVOC43),equine coronavirus(ECoV),and rabbit coronavirus HKU14(RbCoV HKU14)(Corman et al.,2018).BCoV is known to infect a wide range of mammals including domestic and wild ruminants,causing enteritis and pneumonia(Saif,2010).BCoV is ubiquitous in cattle worldwide,even in the respiratory and intestinal samples of healthy individuals,causing major economic losses to the beef and dairy cattle industries(Vlasova and Saif,2021).Importantly,it has been suggested that HCoV-OC43 originated in rodents,and that the major host of BCoV–cattle–acts as intermediate host(Kin et al.,2016;Forni et al.,2017;Corman et al.,2018;Cui et al.,2019).Lin Xu Wei Liu Mengyu Bie Tao Hu Dong Yan Zhishu Xiao Edward C.Holmes Weifeng Shi 2023Virologica Sinica2023,38,2:0
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