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| 1 | Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain显示文摘Epilepsy is considered as a common and diverse set of chronic neurological disorders and its symptoms can be controlled by antiepileptic drugs(AEDs). The presence of p-glycoprotein and multi-drug resistance transporters in the blood-brain barrier could prevent the entry of AEDs into the brain, causing drug resistant epilepsy. To overcome this problem, we propose using carboxymethyl chitosan nanoparticles as a carrier to deliver carbamazepine(CBZ) intranasally with the purpose to bypass the blood-brain barrier thus to enhance the brain drug concentration and the treatment efficacy. Results so far indicate that the developed CBZNPs have small particle size(218.76 ± 2.41 nm) with high drug loading(around 35%) and high entrapment efficiency(around 80%). The in vitro release profiles of CBZ from the NPs are in accordance with the Korsmeyer-peppas model. The in vivo results show that both encapsulation of CBZ in nanoparticles and the nasal route determined the enhancement of the drug bioavailability and brain targeting characteristics. | Shanshan Liu Shili Yang Paul C.Ho | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，1： | 6 |
| 2 | Formulation optimization of scutellarin-loaded HP-β-CD/chitosan nanoparticles using response surface methodology with Box–Behnken design显示文摘The aim of this paper is to investigate and optimize the preparation of scutellarin(SCU)-loaded HP-β-CD/chitosan(CS) nanoparticles(CD/CS-SCU-NPs). CD/CS-SCU-NPs were prepared by ionic cross-linking method and the process and formulation variables were optimized using response surface methodology(RSM) with a three-level, three factor Box–Behnken design(BBD).The independent variables were the added amounts of CS, sodium tripolyphosphate(TPP)and Pluronic F-68 during the preparation. Dependent variables(responses) were particle size and entrapment efficiency. Mathematical equations and respond surface plots were used to correlate independent and dependent variables.The preparation process and formulation variables were optimized to achieve minimum particle size and maximum entrapment efficiency by calculating the overall desirability value(OD). The optimized NP formulation was characterized for particle size, PDI, zeta potential, entrapment efficiency and in vitro drug release.According to the results, an optimized CD/CS-SCU-NP formulation was prepared. Results for particle size, PDI, zeta potential and entrapment efficiency were found to be around 200 nm,0.5, 25 mV, and 70% respectively. For in vitro study, the release of SCU from the NPs exhibited a biphasic release and was in accordance with Higuchi equation. The optimized preparation was simple with the probability for industrialization. The combination use of RSM, BBD and overall desirability values could provide a promising application for incorporating CD into CS nanoparticles as drug delivery carrier and help develop lab-scale procedures. | Shanshan Liu Paul C.Ho | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，4： | 4 |
| 3 | Synthesis,Contact Printing,and Device Characterization of Ni-Catalyzed,Crystalline InAs Nanowires显示文摘InAs nanowires have been actively explored as the channel material for high performance transistors owing to their high electron mobility and ease of ohmic metal contact formation.The catalytic growth of nonepitaxial InAs nanowires,however,has often relied on the use of Au colloids which is non-CMOS compatible.Here,we demonstrate the successful synthesis of crystalline InAs nanowires with high yield and tunable diameters by using Ni nanoparticles as the catalyst material on amorphous SiO_(2) substrates.The nanowires show superb electrical properties with field-effect electron mobility~2700 cm^(2)/Vs and ION/IOFF>10^(3).The uniformity and purity of the grown InAs nanowires are further demonstrated by large-scale assembly of parallel arrays of nanowires on substrates via the contact printing process that enables high performance,“printable”transistors,capable of delivering 510 mA ON currents(~400 nanowires). | Alexandra C.Ford Johnny C.Ho Zhiyong Fan Onur Ergen Virginia Altoe Shaul Aloni Haleh Razavi Ali Javey | 2008 | Nano Research2008，1，1： | 3 |
| 4 | Design and fabrication of 1-D semiconductor nanomaterials for high-performance photovoltaics显示文摘To date, the cost-effective utilization of solar energy by photovoltaics for large-scale deployment remains challenging. Further cost minimization and efficiency maximization, through reduction of material consumption, simplification of device fabrication as well as optimization of device structure and geometry, are required. The usage of 1D nanomaterials is attractive due to the outstanding light coupling effect, the ease of fabrication, and integration with one-dimensional(1-D) semiconductor materials. The light absorption efficiency can be enhanced significantly, and the corresponding light-toelectricity conversion efficiency can be as high as their bulk counterparts. Also, the amount of active materials used can be reduced. This review summarizes the recent development of 1-D nanomaterials for photovoltaic applications, including the anti-reflection, the light absorption,the minority diffusion, and the semiconductor junction properties. With solid progress and prospect shown in the past 10 years, 1-D semiconductor nanomaterials are attractive and promising for the realization of high-efficiency and low-cost solar cells. | Ning Han Zaixing Yang Lifan Shen Hao Lin Ying Wang Edwin Y.B.Pun Yunfa Chen Johnny C.Ho | 2016 | Science Bulletin2016，61，5： | 3 |
| 5 | Crystalline all-inorganic lead-free Cs_(3)Sb_(2)I_(9) perovskite microplates with ultra-fast photoconductive response and robust thermal stability显示文摘Hybrid organolead halide perovskites have attracted tremendous attention due to their recent success as high efficiency solar cell materials and their fascinating material properties uniquely suitable for optoelectronic devices. However, the poor ambient and operational stability as well as the concern of lead toxicity greatly hamper their practical utilization. In this work, crystalline, all-inorganic and lead-free Cs_(3)Sb_(2)I_(9) perovskite microplates are successfully synthesized by a two-step chemical vapor deposition method. As compared with other typical lead-free perovskite materials, the Cs_(3)Sb_(2)I_(9) microplates demonstrate excellent optoelectronic properties, including substantial enhancements in the Stokes shift, exciton binding energy and electron-phonon coupling. Simple photoconductive devices fabricated using these microplates exhibit an ultra-fast response with the rise and decay time constants down to 96 and 58 µs, respectively. This respectable photoconductor performance can be regarded as a record among all the lead-free perovskite materials. Importantly, these photodetectors show superior thermal stability in a wide temperature range, capable to function reversibly between 80 and 380 K, indicating their robustness to operate under both low and high temperatures. All these results evidently suggest the technological potential of inorganic lead-free Cs_(3)Sb_(2)I_(9) perovskite microplates for next-generation high-performance optoelectronic devices. | Sujit Kumer Shil Fei Wang Zhengxun Lai You Meng Yunpeng Wang Dongxu Zhao Mohammad Kamal Hossain Kingsley O.Egbo Ying Wang Kin Man Yu Johnny C.Ho | 2021 | Nano Research2021，14，11： | 1 |
| 6 | Hybrid C8-BTBT/In GaAs nanowire heterojunction for artificial photosynaptic transistors显示文摘The emergence of light-tunable synaptic transistors provides opportunities to break through the von Neumann bottleneck and enable neuromorphic computing.Herein,a multifunctional synaptic transistor is constructed by using 2,7-dioctyl[1]benzothieno[3,2-b][1]benzothiophene(C8-BTBT)and indium gallium arsenide(InGaAs)nanowires(NWs)hybrid heterojunction thin film as the active layer.Under illumination,the Type-I C8-BTBT/InGaAs NWs heterojunction would make the dissociated photogenerated excitons more difficult to recombine.The persistent photoconductivity caused by charge trapping can then be used to mimic photosynaptic behaviors,including excitatory postsynaptic current,long/short-term memory and Pavlovian learning.Furthermore,a high classification accuracy of 89.72%can be achieved through the single-layer-perceptron hardware-based neural network built from C8-BTBT/InGaAs NWs synaptic transistors.Thus,this work could provide new insights into the fabrication of high-performance optoelectronic synaptic devices. | Yiling Nie Pengshan Xie Xu Chen Chenxing Jin Wanrong Liu Xiaofang Shi Yunchao Xu Yongyi Peng Johnny C.Ho Jia Sun Junliang Yang | 2022 | Journal of Semiconductors2022，43，11： | 1 |
| 7 | Smoking is a major risk factor for anastomotic leak in patients undergoing low anterior resection显示文摘 | C. H.Richards V.Campbell C.Ho J.Hayes T.Elliott M.Thompson‐Fawcett | 2012 | Colorectal Disease2012，，5： | 1 |
| 8 | Recent progress on the long-term stability of hydrogen evolution reaction electrocatalysts显示文摘Developing new methodologies to produce clean and renewable energy resources is pivotal for carbon-neutral initiatives.Hydrogen(H2)is considered as an ideal energy resource due to its nontoxic,pollution-free,high utilization rate,and high calorific combustion value.Electrolysis of water driven by the electricity generated from renewable and clean energy sources(e.g.,solar energy,wind energy)to produce hydrogen attracts great efforts for hydrogen production with high purity.Recently,the breakthrough of the catalyst activity limit for the hydrogen evolution reaction(HER)catalysts has received extensive attention.Comparatively,fewer reviews have focused on the long-term stability of HER catalysts,which is indeed decisive for large-scale electrolytic industrialization.Therefore,a systematic summary concentrated on the durability of HER electrocatalysts would provide a fundamental understanding of the electrocatalytic performance for practical applications and offer new opportunities for the rational design of the highly performed HER electrocatalysts.This review summarizes the research progress toward the HER stability of precious metals,transition metals,and metal-free electrocatalysts in the past few years.It discusses the challenges in the stability of HER electrocatalysts and the future perspectives.We anticipate that it would provide a valuable basis for designing robust HER electrocatalysts. | Wenfang Zhai Yuanyuan Ma Dong Chen Johnny C.Ho Zhengfei Dai Yongquan Qu | 2022 | InfoMat2022，4，9： | 1 |
| 9 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 10 | An integrated MRP and JIT framework显示文摘 | Johnny C.Ho Yih-Long Chang | | 0，，02： | 1 |
| 11 | Learning new meanings for old words:Effects of semantic relatedness显示文摘 | Rodd J.M R.Berriman M.Landau T.Lee C.Ho M.G.Gaskell & M.H.Davis | | 0，，07： | 1 |
| 12 | 不同方式重组表达鼠疫caf1M蛋白的研究显示文摘目的对比不同方式克隆表达鼠疫耶尔森氏菌caf1M蛋白的存在状态及免疫学活性。方法分别选择3种不同载体pET32a(+)、pGEX4t-1、pGBTNH,克隆表达鼠疫caf1M蛋白;并以鼠疫菌免疫血清分别检测其免疫学活性。结果成功构建了4个重组质粒,分别是含去除信号肽编码序列caf1M基因的3个质粒载体,及1个含有完整caf1M基因的pGEX4t-1表达质粒;4个质粒经诱导均在大肠杆菌中得到高效表达;存在状态分析表明,含有去除信号肽编码序列caf1M基因的pGEX4t-1表达的重组蛋白以可溶方式存在,其余3种以包涵体形式存在;重组蛋白与鼠疫菌免疫血清的Western blot分析表明,除pGBTNH表达的蛋白存在非特异反应外,其余3种重组蛋白都发生特异性反应。结论成功克隆表达了4种鼠疫菌caf1M蛋白,其中3种具有良好的特异性免疫反应性;信号肽序列及载体都对重组caf1M蛋白的表达有影响。 | 杜春红 王鹏 Tiffany C.Ho 张建中 宋志忠 董兴齐 | 2012 | 中国地方病防治2012，27，2： | 1 |
| 13 | Mapping HⅠ in the NGC 4636 Galaxy Group with FAST显示文摘This paper presents data from a 21 cm H I emission drift scan observation of a field partially covering the NGC 4636 galaxy group with the Five-hundred meter Aperture Radio Telescope(FAST). We construct a pipeline to reduce the data, and use So Fi A for source finding. When not contaminated by Radio Frequency Interference(RFI), the FAST observations are capable of detecting all of the galaxies previously detected by the Arecibo Legacy Fast ALFA(ALFALFA) survey in the same region. Comparing to ALFALFA for the detections in common, the FAST data show consistent integrated spectra when the H I disks are spatially unresolved, and capture more flux when the H I disks are resolved. The FAST data further reveal 10 new detections in the region mutually covered with ALFALFA, and 18 new detections beyond the footprint of ALFALFA. All of the new detections have the matching optical counterparts. For the member galaxies of the NGC 4636 group, the detection limit of FAST is deeper by 0.4 dex in H I mass than that of the ALFALFA data. After correcting for the incompleteness caused by RFI contamination, we show that the H I detection rate of galaxies rises steeply with radius out to the virial radius of the group, and flattens beyond that. We also examine four spatially resolved galaxy systems with potential tidal interaction features in detail. Considering that the data have been taken during the“shared-risk” period before a major source of local RFI was eliminated, the results highlight the power of FAST in detecting extragalactic H I. | Pei Zuo Dong Yang Jing Wang Lister Staveley-Smith Xuchen Lin Bi-Qing For Tobias Westmeier Jie Wang Kristine Spekkens Virginia Kilborn O.Ivy Wong Di Li Karen Lee-Waddell Barbara Catinella Luis C.Ho Barbel Koribalski Bumhyun Lee Ming Zhu | 2022 | Research in Astronomy and Astrophysics2022，22，9： | 0 |
| 14 | 场效应管振荡器长期频漂分析显示文摘本文分析了11千兆赫砷化镓场效应管介质谐振器稳频振荡器中观察到的长期频漂。该分析以建立器件的模型为基础进行的。分析中发现,对长期频漂起主要影响的是砷化镓场效应管的栅源沟道电容的分析结果与介质谐振器中观察到的变化趋向一致,而且理论与测量数据之间达到了很好的相关。这些观察结果普遍适用于以砷化镓场效应管作有源器件的所有振荡器。 | K.K.Agarwal C.Ho 张少时 | 1989 | 现代雷达1989，11，4： | 0 |
| 15 | Is platinum a suitable counter electrode material for electrochemical hydrogen evolution reaction?显示文摘To date,due to the excellent electrochemical inertness,superb electrical conductivity and good mechanical stability in both aqueous and nonaqueous solutions,platinum(Pt)has been widely employed as counter electrode material in three-electrode setups to perform electroanalytical chemistry.However,recent reports have revealed that the use of Pt based counter electrodes | Renjie Wei Ming Fang Guofa Dong Johnny C.Ho | 2017 | Science Bulletin2017，62，14： | 0 |
| 16 | The origin of gate bias stress instability and hysteresis in monolayer WS2 transistors显示文摘Due to the ultra-thin nature and moderate carrier mobility,semiconducting two-dimensional(2D)materials have attracted extensive attention for next-generation electronics.However,the gate bias stress instability and hysteresis are always observed in these 2D materials-based transistors that significantly degrade their reliability for practical applications.Herein,the origin of gate bias stress instability and hysteresis for chemical vapor deposited monolayer WS2 transistors are investigated carefully.The transistor performance is found to be strongly affected by the gate bias stress time,sweeping rate and range,and temperature.Based on the systematical study and complementary analysis,charge trapping is determined to be the major contribution for these observed phenomena.Importantly,due to these charge trapping effects,the channel current is observed to decrease with time;hence,a rate equation,considering the charge trapping and time decay effect of current,is proposed and developed to model the phenomena with excellent consistency with experimental data.All these results do not only indicate the validity of the charge trapping model,but also confirm the hysteresis being indeed caused by charge trapping.Evidently,this simple model provides a sufficient explanation for the charge trapping induced gate bias stress instability and hysteresis in monolayer WS2 transistors,which can be also applicable to other kinds of transistors. | Changyong Lan Xiaolin Kang You Meng Renjie Wei Xiuming Bu SenPo Yip Johnny C.Ho | 2020 | Nano Research2020，13，12： | 0 |
| 17 | High elasticity of CsPbBr_(3) perovskite nanowires for flexible electronics显示文摘Due to the enhanced ambient structural stability and excellent optoelectronic properties, all-inorganic metal halide perovskite nanowires have become one of the most attractive candidates for flexible electronics, photovoltaics and optoelectronics. Their elastic property and mechanical robustness become the key factors for device applications under realistic service conditions with various mechanical loadings. Here, we demonstrate that high tensile elastic strain (∼ 4% to ∼ 5.1%) can be achieved in vapor-liquid-solid-grown single-crystalline CsPbBr_(3) nanowires through in situ scanning electron microscope (SEM) buckling experiments. Such high flexural elasticity can be attributed to the structural defect-scarce, smooth surface, single-crystallinity and nanomechanical size effect of CsPbBr_(3) nanowires. The mechanical reliability of CsPbBr_(3) nanowire-based flexible photodetectors was examined by cyclic bending tests, with no noticeable performance deterioration observed after 5,000 cycles. The above results suggest great application potential for using all-inorganic perovskite nanowires in flexible electronics and energy harvesting systems. | Xiaocui Li You Meng Rong Fan Sufeng Fan Chaoqun Dang Xiaobin Feng Johnny C.Ho Yang Lu | 2021 | Nano Research2021，14，11： | 0 |
| 18 | Self-assembling nacre-like high-strength and extremely tough polymer composites with new toughening mechanism显示文摘Achieving high strength,deformability and toughness in polymers is important for practical industrial applications.This has remained challenging because of the mutually opposing effects of improvements to each of these properties.Here,a self-assembling nacre-like polymer composite is designed to achieve ex-tremely tough with increasing strength.This special design significantly improved polymer’s mechanical properties,including an ultra-high fracture strain of 1180%,a tensile strength of 55.4 MPa and a toughness of 506.9 MJ/m^(3),which far exceed the highest values previously reported for polymer composites.This ex-cellent combination of properties can be attributed to a novel toughening mechanism,achieved by the synergy of the domain-limiting effect of metallic glass fragments with the strain-gradient-induced orien-tation and crystallisation within the polymer during stretching.Our approach opens a promising avenue for designing robust polymer materials in armour and aerospace engineering for a range of innovative applications. | Yu Bu Xu Wang Xiuming Bu Zhengyi Mao Zhou Chen Zebiao Li Fengqian Hao Johnny C.Ho Jian Lu | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
| 19 | Luminescent concentrators enable highly efficient and broadband photodetection显示文摘With luminescent concentrators,the high quantum yield luminescence emitted by embedded chromophores,featuring a broad absorption spectrum,can be well-tuned to match the peak response of integrated photodetectors.This integration can substantially enhance the device photoresponse all the way from deep UV to near-IR. | Wei Wang Johnny C.Ho | 2022 | Light(Science & Applications)2022，11，6： | 0 |
| 20 | 鼠疫耶尔森菌纤维蛋白溶解酶原激活因子蛋白及其特异性片段的原核表达显示文摘目的重组表达鼠疫耶尔森菌纤维蛋白溶解酶原激活因子(Plasminogen activator,PIa)蛋白及其特异性片段并检测其免疫反应性。方法以鼠疫EV76株为模板,PCR扩增pla,pla-c基因,并与质粒原核表达载体(prokaryotic expression vector,pET)32a(+)连接,将pET32a(+)-pla、pET32a(+)-pla—c分别转化E.coliBL21(DE3)诱导表达;产物经镍离子金属螯合亲和层析纯化,免疫印迹(Westernblot)法鉴定其免疫反应性。结果所表达的Pla蛋白相对分子质量(Mr)为52.8×10。,以包涵体形式存在;Pla—c蛋白Mr为24.0x10s,以可溶形式存在;这两个蛋白质均可与鼠疫免疫血清产生特异结合反应。结论所表达的鼠疫菌Pla及其特异性片段具有免疫反应性,为辅助诊断鼠疫提供了选择。 | 杜春红 王鹏 Tiffany C.Ho 董兴齐 宋志忠 吴锡南 张建中 | 2012 | 中国地方病学杂志2012，31，5： | 0 |
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