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| 1 | Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases显示文摘AIM To evaluate the levels of von Willebrand factor(VWF) and metalloproteinase with thrombospondin type-1 motif, number 13(ADAMTS13) in inflammatory bowel disease(IBD) and correlate them with the disease activity.METHODS Consecutive patients with IBD aged 18 years or older were enrolled in the study. Forty-seven patients with ulcerative colitis(UC), 38 with Crohn's disease(CD), and 50 healthy controls were included. The white blood cell count, haematocrit, platelet count, fibrinogen, partial activated thromboplastin time, C-reactive protein, albumin, VWF antigen level(VWF:Ag), VWF ristocetin cofactor activity(VWF:RCo), VWF collagen-binding activity(VWF:CB), and ADAMTS13 antigen level(ADAMTS13:Ag) and activity(ADAMTS13act) were measured. The following ratios were assessed: V W F : R C o/V W F : A g, V W F : C B/V W F : A g, V W F : A g/ADAMTS13 act, and ADAMTS13act/ADAMTS13:Ag. RESULTS Compared to controls, the odds ratio(OR) of an elevated VWF: Ag > 150% was 8.7(95%CI: 2.7-28.1) in the UC group and 16.2(95%CI: 4.8-54.0) in the CD group. VWF:CB was lower in UC patients, and active CD was associated with a higher VWF: RCo(+38%). The ORs of VWF:CB/VWF:Ag < 0.7(a marker of acquired von Willebrand syndrome) in the UC and CD groups were 11.9(95%CI: 4.4-32.4) and 13.3(95%CI: 4.6-38.1), respectively. Active UC was associated with lower ADAMTS13:Ag(-23%) and ADAMTS13act(-20%) compared to UC in remission. Patients with active CD had a 15% lower ADAMTS13 act than controls. The activity of UC, but not that of CD, was inversely correlated with ADAMTS13:Ag(r =-0.76) and ADAMTS13act(r =-0.81). CONCLUSION Complex VWF-ADAMTS13-mediated mechanisms disturb haemostasis in IBD. A reduced WVF:CB is a risk factor for bleeding, while a lower ADAMTS13 level combined with an elevated VWF:Ag could predispose one to thrombosis. | Dorota Cibor Danuta Owczarek Saulius Butenas Kinga Salapa Tomasz Mach Anetta Undas | 2017 | World Journal of Gastroenterology2017，23，26： | 3 |
| 2 | Serum Peptidome Patterns of Colorectal Cancer Based on MagneticBead Separation and MALDI-TOF Mass Spectrometry Analysis显示文摘 | Nai-Jun Fan Chun-Fang Gao Xiu-Li Wang Guang Zhao Qing-Yin Liu Yuan-Yao Zhang Bao-Guo Cheng Saulius Butenas | 2012 | <journal-title>Journal of Biomedicine and Biotechnology2012，，： | 2 |
| 3 | Homocysteine inhibits inactivation of factor Va by activated protein C显示文摘 | Undas A Williams EB Butenas S | 2001 | Biol Chem2001，276，6： | 1 |
| 4 | Active tissue factorand activated factor XI in circulating blood of patientswith systolic heart failure due to ischemiccardiomyopathy 显示文摘 | Zabczyk M Butenas S Palka I | 2010 | Pol Arch Med Wewn2010，120，9： | 1 |
| 5 | The function of factor Ⅺ in tissue factor-initiated thrombin generation显示文摘 | Butenas S Dee JD Mann KG | 2003 | J Thromb Haemost2003，1，10： | 1 |
| 6 | Immunologic quantitation of tissue factors 显示文摘 | Parhami-Seren B Butenas S Krudysz-Amblo J etal | 2006 | JThromb Haemost2006，4，8： | 1 |
| 7 | Product-dependent anti-factor V~ antibodies 显示文摘 | Butenas S1 Krudysz-Amblo J Rivard GE | 2013 | Haemophilia2013，19，4： | 1 |
| 8 | Tissue factoractivity in whole blood显示文摘 | Butenas S Bouchard BA Brummel-Ziedins KE | 2005 | Blood2005，105，7： | 1 |
| 9 | Tissue factor in coagulation : which? where? when? 显示文摘 | Butenas S Orfeo T Mann KG | 2009 | Arterioscler Thromb Vase Boil2009，29，12： | 1 |
| 10 | Tissue factor in thrombosis and hemorrhage 显示文摘 | BUTENAS S ORFEO T MANN KG | 2007 | Surgery2007，142，4： | 1 |
| 11 | The dynamics of thrombin formation 显示文摘 | Mann KG Butenas S Brummel K | 2003 | Arterioscler Thromb Vasc Biol2003，23，1： | 1 |
| 12 | Decryption of tissue factor显示文摘 | Butenas S Krdyszu-Amblo J | 2012 | Thremb Res2012，129，2： | 1 |
| 13 | Mechanism of factor Ⅶ a-dependent coagulation in hemophilia blood显示文摘 | BUTENAS S BRUMMEL K E BRANDA R F | 2002 | Blood2002，99，： | 1 |
| 14 | The dynamics of throm- bin formation显示文摘 | Mann KG Butenas S Brummel K | 2003 | Arterioscler Thromb Vas Biol2003，23，1： | 1 |
| 15 | How factor Ⅶ a works in hemophilia显示文摘 | BUTENAS S BRUMMEL K E BOUCHARD B A | 2003 | J Thromb Haemost2003，1，： | 1 |
| 16 | The influence of von Willebrand factor on factor Ⅷ activity mesurements 显示文摘 | Butenas S Parhami-Seren B Mann KG | 2009 | Thromb Haemost2009，7，1： | 1 |
| 17 | Antiplatelet agents in tissue factor-induced blood coagulation显示文摘 | Butenas S Cawthern KM van′t Veer C | 2001 | Blood2001，97，8： | 1 |
| 18 | The dynamics of thrombin formation显示文摘 | MANN KG BUTENAS S BRUMMEL K | 2003 | Arterioscler Thromb Vasc Biol2003，23，1： | 1 |
| 19 | An integrated study of fibrinogen during blood coagulation显示文摘 | Brummel K E Butenas S Mann K G | 1999 | J Biol Chem1999，274，22： | 1 |
| 20 | Tissue factor activity in whole blood 显示文摘 | Butenas S Bouchard BA Brunwael-Ziedins KE | 2005 | Blood2005，105，7： | 1 |
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