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| 1 | Future impact of integrated high-throughput methylome analyses on human health and disease显示文摘A spate of high-powered genome-wide association studies (GWAS) have recently identified numerous single-nucleotide polymor-phisms (SNPs) robustly linked with complex disease. Despite interrogating the majority of common human variation, these SNPs only account for a small proportion of the phenotypic variance, which suggests genetic factors are acting in concert with non-genetic factors. Although environmental measures are logical covariants for genotype-phenotype investigations, another non-genetic intermediary exists: epigenetics. Epigenetics is the analysis of somatically-acquired and, in some cases, transgenerationally inherited epigenetic modifications that regulate gene expression, and offers to bridge the gap between genetics and environment to understand phenotype. The most widely studied epigenetic mark is DNA methylation. Aberrant methylation at gene promoters is strongly implicated in disease etiology, most notably cancer. This review will highlight the importance of DNA methylation as an epigenetic regulator, outline techniques to character-ize the DNA methylome and present the idea of reverse phenotyping, where multiple layers of analysis are integrated at the individual level to create personalized digital phenotypes and, at a phenotype level, to identify novel molecular signatures of disease. | Lee M Butcher Stephan Beck | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
| 2 | Approximation approach to performance evaluation of proxy cache server systems显示文摘 | Butcher M | 2009 | AnnalesMathematicae et Informati- cae2009，36，8： | 1 |
| 3 | 1 - (2-Hy-droxy-eth-yl) -4- piperazine-1,4-di- ium dichloride : the dihydro-chloride logr Sect E Struct Rep Online,2011 salt of flupentixol 显示文摘 | Siddegowda MS Butcher R J Akkurt M | 2011 | Acta Crystal-2011，67，8： | 1 |
| 4 | Con- duction and Breakdown Mechanisms in Transformer Oil 显示文摘 | Butcher M Neuber A A Cevallos M D | 2006 | IEEE Transactions on Plasma Science2006，34，2： | 1 |
| 5 | ACSM position stand: the recommended quantity and quality of exercise for developing and maintaining car- diorespiratory and muscular fitness, and flexibility in healthy adults显示文摘 | Pollock M L Gaesser G A Butcher J D | 1998 | Medicine & Science in Sports & Exer- cise1998，30，6： | 1 |
| 6 | Postt- hrombolysis blood pressure elevation is associated with hemorrhagic transformation显示文摘 | BUTCHER K CHRISTENSEN S PARSONS M | 2010 | Stroke2010，41，1： | 1 |
| 7 | A Benthic community index for streams in the northern lakes and forests ecoregion 显示文摘 | Butcher J T Stewar P M Simon T P | 2003 | Ecological Indicators2003，3，3： | 1 |
| 8 | Diatom (Bacillariophyta)community response to water quality and land use显示文摘 | Stewart P M Butcher J T Gerovac P J | 1999 | Natural Areas Journal1999，19，： | 1 |
| 9 | Blockade of interleukin- 17A results in reduced atherosclerosis in apolipoprotein E-defi- cient mice显示文摘 | Smith E Prasad KM Butcher M | 2010 | Circulation2010，121，15： | 1 |
| 10 | A cell-surface moleculemvalved in organ-specific homing of lymphocytes 显示文摘 | Callatin V M Weissman I L Butcher E L | 1983 | Nature1983，304，： | 1 |
| 11 | Advanced imaging in acute stroke management-Part Ⅱ:magnetic resonance imaging显示文摘 | Saini M Butcher K | | 0，，05： | 1 |
| 12 | Remedial action in the management of woundrelated pain 显示文摘 | Butcher M White R | 2014 | Nuts Stand2014，28，46： | 1 |
| 13 | Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung显示文摘 | Vardey CJ Johnson M | 1991 | Br J Pharmacol1991，104，： | 1 |
| 14 | Medical management of intracerebral hemorrhage 显示文摘 | Butcher K Baird T Parsons M | 2002 | Neurosurg Q2002，12，4： | 1 |
| 15 | Lymphocyte trafficking and regional immunity 显示文摘 | Butcher EC Williams M Youngman K | 1999 | Adv Immunol1999，72，： | 1 |
| 16 | Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation显示文摘 | Butcher K Christensen S Parsons M | 2010 | Stroke2010，41，1： | 1 |
| 17 | A criterion for the time-dependent of dynamic fracture显示文摘 | Tuler F R Butcher B M | 1968 | Journal of Fracture Mechanics1968，4，： | 1 |
| 18 | Medical management of intracerebral hemorrhage显示文摘 | Butcher K Baird T Parsons M | 2002 | Neurosurg Quart2002，12，4： | 1 |
| 19 | A criterion for the time-dependent of dynamic fracture显示文摘 | Butcher B M | 1968 | J Fra Mech1968，4，： | 1 |
| 20 | Genotyping pooled DNA using 100K SNP microarrays: a step towards genome- wide association scans 显示文摘 | Meaburn E Butcher L M Schalkwyk L C | 2006 | Nucleic Acids Res2006，34，： | 1 |
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