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| 1 | Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice显示文摘AIM:To evaluate the protective effects on kidney tissue of frequently used intravenous anesthetics(ketamine,propofol,thiopental,and fentanyl)in rats with obstructive jaundice.METHODS:There is an increased incidence of postoperative acute renal failure in patients with obstructive jaundice.Thirty-two Wistar-albino rats were randomly divided into four equal groups.Laparatomy was performed on each animal in the four groups and common bile ducts were ligated and severed on day 0.After 7 d,laparotomy was again performed using ketamine,propofol,thiopental,or fentanyl anesthesia whose antioxidative properties are well known in oxidative stress in a rat liver model of obstructive jaundice.After 2 h,the rats were sacrificed.Renal tissue specimens were analyzed for catalase,superoxide dismutase and malondialdehyde enzymes activities.All values are expressed as the mean±SD.P values less than 0.05 were considered statistically significant.RESULTS:All animals survived without complications until the end of the study.Enlargement in the bile duct and obstructive jaundice were observed in all rats.Catalase was found to be significantly lower in the fentanyl group than in the ketamine(P=0.039),propofol(P=0.012),and thiopental(P=0.001)groups.Superoxide dismutase activities were similar in all groups(P>0.05).Malondialdehyde was found to be significantly lower in the ketamine group than in the propofol(P=0.028),thiopental(P=0.002)and fentanyl(P=0.005)groups.Malondialdehyde was also lower in the fentanyl group than in the thiopental group(P=0.001).The results showed that obstructive jaundice sensitizes renal tissue to damage under the different anesthetics.CONCLUSION:Among the agents tested,ketamine and propofol generated the least amount of oxidative stres on renal tissues in this rat model of obstructive jaundice created by common bile duct ligation.The importance of free radical injury in renal tissue in obstructive jaundice under different intravenous anesthetics during hepatobiliary and liver transplant surgery should be considered for prevention of postoperative acute renal failure. | Sinan Hatipoglu Huseyin Yildiz Ertan Bulbuloglu Ismail Coskuner Ergul Belge Kurutas Filiz Hatipoglu Harun Ciralik Mehmet Sait Berhuni | 2014 | World Journal of Gastroenterology2014，20，12： | 9 |
| 2 | Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study显示文摘AIM To evaluate whether there was any correlation between the clinical parameters and final pathological results among patients who underwent thyroid surgery. METHODS We retrospectively analyzed parameters, including age, sex, complete blood cell count parameters, nodule diameter, nodule localization, thyroid function testing, and pathology reports, in patients who underwent thyroid surgery. The patients were divided into malignant (n = 92) and benign (n = 413) groups depending on the final pathological results. Both groups were compared for demographic and clinicalparameters. The Kolmogorov-Smirnov normality test was used to determine if the quantitative variables had a normal distribution. The nonparametric MannWhitney U test was used to compare quantitative data that were not normally distributed, and Pearson's chisquared test was used to compare the qualitative data. The correlation between the final pathological results and fine-needle aspiration biopsy findings was calculated using the cross-tabulation method.RESULTS This study included 406 women and 99 men aged between 15 and 85 years. No significant differences were found between the groups with respect to age, sex, white blood cell count, neutrophil count, lymphocyte count, thrombocyte count, red cell distribution width, platelet distribution width, mean platelet volume, platecrit, nodule localization, and thyroid function testing. On the other hand, there were significant differences between the groups with respect to nodule size (P = 0.001), cervical lymphadenopathy(P = 0.0001) and nodular calcification (P = 0.0001). Compared with the malignant group, the benign group had a significantly greater nodule size (35.4 mm vs 27.6 mm). The best cut-off point (≤ 28 mm) for nodule size, as determined by the receiver operating characteristic curve, had a sensitivity and specificity of 67.7% and 64.4%, respectively. The correlation between fine-needle aspiration biopsy and the final pathological results was assessed using the cross-table method. The sensitivity and specificity of fine-needle aspiration biopsy were 60% and 98%, respectively.CONCLUSION This study showed that significant differences existed between the malignant and benign groups with regard to nodule size, cervical lymphadenopathy, and nodular calcification. | Arif Emre Sami Akbulut Mehmet Sertkaya Muharrem Bitiren Ilhami Taner Kale Ertan Bulbuloglu Cemil Colak | 2018 | World Journal of Clinical Cases2018，6，3： | 2 |
| 3 | Zinc aspartate alleviates lung injury induced by intestinal ischemia reperfusion inrats 显示文摘 | Tirtt H Kurutas EB Bulbuloglu E | 2009 | J SurgRes2009，151，1： | 1 |
| 4 | Re-protective effects of pre and post-laparoscopy conditioning, zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the kidney 显示文摘 | Oksuz H Bulbuloglu E Senoglu N | 2009 | RenFail2009，31，4： | 1 |
| 5 | Protective effects ofzinc, pentoxifylline, and N-acetylcysteine in an animal model oflaparoscopy-induced ischemia/reperfusion injury of the smallintestine显示文摘 | Bulbuloglu E’Yildiz H Senoglu N | 2011 | J Laparoendosc Adv Surg Tech A2011，21，10： | 1 |
| 6 | Incidental pheochromoeytoma presenting with sublaboratory findings in asymptomatie surrenal masses :a ease report显示文摘 | Ozkaya M Yuzbasioglu MF Bulbuloglu E | 2008 | Cases J2008，1，1： | 1 |
| 7 | Protective effects of zinc, pentoxifylline, and N-acetylcysteine in an animal model oflaparoscopy-induced ischemia/reperfusion injury of the small intestine显示文摘 | Bulbuloglu E Yildiz H Senoglu N | 2011 | J Laparoendosc Adv Surg Tech A2011，21，10： | 1 |
| 8 | Incidental pheochromocytoma presenting with sublaboratory findings in asymptomatic surrenal masses: a case report 显示文摘 | Ozkaya M Yuzbasioglu MF Bulbuloglu E | 2008 | Cases J2008，1，1： | 1 |
| 9 | Cilostazol and diltiazem attenuate cyclosporine-induced nephrotoxicity in rats显示文摘 | Gokce M Yuzbasioglu MF Bulbuloglu E | | 0，，： | 1 |
| 10 | Administration of honey to prevent peritoneal adhesions in a rat peritonitis model 显示文摘 | Yuzbasioglu M Kurutas EB Bulbuloglu E | 2009 | Int J Surg2009，7，1： | 1 |
| 11 | Incidental pheochro- mocytoma presenting with sublaboratory findings in asymptomatic surrenal masses: a case report显示文摘 | Ozkaya M Yuzbasioglu MF Bulbuloglu E | 2008 | Cases J2008，1，1： | 1 |
| 12 | Tuberculosis of the thyroid gland:review of the literature显示文摘 | Bulbuloglu E Ciralik H Okur E Ozdemir G Ezberci F Cetinkaya A | 2006 | World J Surg2006，30，2： | 1 |
| 13 | Protective effects of zinc,pentoxifylline,and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the small intestine显示文摘 | Bulbuloglu E Yildiz H Senoglu N | 2011 | J Laparoendosc Adv Surg Tech A2011，21，10： | 1 |
| 14 | Re-protective effectsof pre- and post-laparoscopy conditioning, zinc, pentoxifylline,and N-acetylcysteine in an animal model of laparoscopy-inducedischemia/ reperfusion injury of the kidney 显示文摘 | Oksuz H Bulbuloglu E Senoglu N | 2009 | Ren Fail2009，31，4： | 1 |
| 15 | Effects of N-acetylcysteine on methotrexate-induced small intestinal damage in rats显示文摘 | Ciralik H Bulbuloglu E Cetinkaya A | 2006 | Mt Sinai J Med2006，73，8： | 1 |
| 16 | Zinc aspartate alleviates lung injury induced by intestinal ischemia- reperfusion in rats显示文摘 | Turut H Kurutas EB Bulbuloglu E | 2009 | J Surg Res2009，151，1： | 1 |
| 17 | Beneficial effects of N - acetylcysteine on acetic acid - induced colitis in rats 显示文摘 | Cetinkaya A Bulbuloglu E Kurutas EB | 2005 | Tohoku J Exp Med2005，，206： | 1 |
| 18 | Intraperitoneal tenoxicam to prevent abdominal adhesion formation in a rat peritonitis model显示文摘 | Ezberci F Bulbuloglu E Ciragil P | 2006 | Surg Today2006，36，4： | 1 |
| 19 | Protective effects of zinc,pentoxifylline,and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the small in- testine显示文摘 | Bulbuloglu E Yildiz H Senoglu N | 2011 | J Laparoendosc Adv Surg Tech A2011，21，10： | 1 |
| 20 | splenic hydatic cyst as a cause of sinistral portalhypertension and isolated gastric variceal bleeding显示文摘 | Kantar9eken B Qet lnkaya A Bulbuloglu E | 2010 | Turk J Gastroenterol2010，21，3： | 1 |
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