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| 1 | 乌司奴单抗在预防克罗恩病术后复发方面较硫唑嘌呤更有效显示文摘克罗恩病(CD)为慢性肠道损伤性疾病。近几年在免疫抑制剂和生物制剂广泛应用的前提下,仍有半数患者在确诊之后的10年内必须手术治疗。而手术并不能治愈CD,如何预防术后复发仍是目前热点话题。乌司奴单抗是一种人源化IgG1k单克隆抗体﹐是白细胞介素(IL)-12和IL-23的p40蛋白亚单位拮抗剂。既往研究表明,乌司奴单抗和安慰剂相比。 | 国明月(译) Buisson A Nancey S Manlay L | 2021 | 中华医学杂志2021，101，22： | 2 |
| 2 | Mechanism involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia显示文摘 | Buisson A Margaill L Callehert J | 1993 | J Neurochem1993，61，2： | 1 |
| 3 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 4 | Avalanche starting-zone analysis by use ofknowledge - based system 显示文摘 | Buisson L Charlier C | 1989 | Annals of Glaciology1989，13，： | 1 |
| 5 | First -line therapyin adult Crohn, s disease: who should receiveanti - TNF agents-显示文摘 | Peyrin-Biroulet L FiorinoG Buisson A | 2012 | Nat Rev Gastro Hepatol2012，272，： | 1 |
| 6 | Fundemental diagram estimation through passing rate measurements in congestion显示文摘 | CHIABAUT N BUISSON C LECKERCQ L | 2009 | IEEE Transactions on Intelligent Transporta- tion Systems2009，10，2： | 1 |
| 7 | Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia显示文摘 | Margai L Calleber J | 1993 | J Neurochem1993，6，： | 1 |
| 8 | Nitric oxide:an endogenous anticonvulsant substance显示文摘 | Lakhmeche N Verrechiac L | 1993 | Neuroreport1993，4，： | 1 |
| 9 | A comparison ofthe daily alkaline phosphatase activity of a cyanobactcrium(Microcystis aeruginosa)and a diatom(Synedra capitata)显示文摘 | Giraudet H Berthon J L Buisson B | 1997 | Comptes Rendus De L Academie Des Sciences Serie Iii-Sciences De La Vie Life Sciences1997，320，6： | 1 |
| 10 | Irnmunogenici- ty of CIGB-230, a therapeutic DNA vaccine preparation, in HCV-chronically infected individuals in a phase I clinical tri- al 显示文摘 | Alvarez-Lajonchere L Shoukry NH Gr6 B Amador- Cafiizares Y Helle F B6dard N Guerra I Drouin C Du- buisson J Gonz6lez-Horta EE Martlnez G Marante J Cinza Z Castellanos M Duefias-Carrera S | 2009 | J Viral Hepat2009，16，3： | 1 |
| 11 | Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia显示文摘 | Margai L Calleber J | 1993 | J Neurochem1993，61，： | 1 |
| 12 | Occurrence of a non deleterious gene conversion event in the BRCA 1 gene显示文摘 | Chloé Tessereau Mélanie Léoné Monique Buisson Laurent Duret Olga M. Sinilnikova Sylvie Mazoyer | 2015 | Genes Chromosomes Cancer2015，，： | 1 |
| 13 | Calibration and validation of probabilistic discretionary lane-change models 显示文摘 | Knoop V L Buisson C | 2015 | IEEE Transactions on Intelligent Transportation Sys- tems2015，16，2： | 1 |
| 14 | Climate change hastens the turnover of stream fish assembla- ges 显示文摘 | BUISSON L THUILLER W LEK S | 2008 | Global Change Biology2008，14，10： | 1 |
| 15 | Reconstruction of degrad- ed image sequences, application to film restoration 显示文摘 | JOYEUX L BUISSON O BESSERER B | 2001 | Image and Vision Computing2001，，19： | 1 |
| 16 | Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia显示文摘 | Buisson A Margai L Calleber J | 1993 | J Neurochem1993，61，： | 1 |
| 17 | Neurotoxicity of channel mutations in heterologously expressed c~7-nicotinic acetylcholine receptors 显示文摘 | Lukas R J Lucero L Buisson B | 2001 | J Neurosci2001，13，： | 1 |
| 18 | Mechaisma involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral aschemia 显示文摘 | Buisson A Margaill L Callehert J | 2001 | J Neurochem2001，61，2： | 1 |
| 19 | Contrasted impacts of climate change on stream fish assemblages along an environmental gradient显示文摘 | Buisson L G-renouillet G | 2009 | Divers Distrib2009，15，： | 1 |
| 20 | The European survey (alive) of acute lung injury and ARDS 显示文摘 | Brun - Buisson C Minelli C Brazzi L | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
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