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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | 眼睛的信号显示文摘有一句人们熟悉的俗语:眼睛是灵魂之窗。银行出纳员会仔细注意一个眼睛躲闪的顾客;精神病医生会观察一个想自杀的病人毫无表情的目光。这种观察的窗口已被新近研究所证实。研究表明,眼睛运动暗示着脑如何搜集或筛选信息,此外,眼晴运动的各种式样一直与心理失调相关,甚至与诸如社交性内向等个性品质相关联。 | M S Buchsbaum 韩向前 | 1986 | 应用心理学1986，，3： | 2 |
| 3 | Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy显示文摘 | Arif H Buchsbaum R Pierro J | 2010 | Arch Neurol2010，67，4： | 1 |
| 4 | Ventricular en- largement in schizophrenia related to volume reduction of the thalamus, striatum, and superiortemporal cortex 显示文摘 | Gaser C Nenadic I Buchsbaum B R | 2004 | Am J Psychiatry2004，161，1： | 1 |
| 5 | Three-dimensional analysis with MRI and PET of the size,shape,and function of the thalamus in the schizophrenia spectrum显示文摘 | Buchsbaum MS Byne W | 1999 | Am J Psychiatry1999，156，8： | 1 |
| 6 | Intercellular adhesion molecule expression in the evolving human cutaneous delayed hypersensitivity reaction 显示文摘 | Lewis RE Buchsbaum M Whitaker D | 1989 | J Invest Dermatol1989，93，5： | 1 |
| 7 | Targeting strategies for cancer radiotherapy显示文摘 | Rogers BE Khazaeli MB | 1999 | Clin Cancer Res1999，5，10： | 1 |
| 8 | Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway显示文摘 | Ohtsuka T Buchsbaum D Oliver P | 2003 | Oncogene2003，22，13： | 1 |
| 9 | Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex显示文摘 | Gaser C Nenadic I Buchsbaum BR | 2004 | Am J Psychiatry2004，161，1： | 1 |
| 10 | A noninvasive receptor system to image adenoviral-mediated gene transfer to ovarian cancer xenografts显示文摘 | Rogers BE Buchsbaum DJ | 2001 | Gynecol Oncol2001，83，2： | 1 |
| 11 | Adenovirus - mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells显示文摘 | KALIBEROV S A BUCHSBAUM D J GILLESPIE G Y | 2002 | Mol Ther2002，6，8： | 1 |
| 12 | jnter-cellular adhesion molecule expression in theevolving human cutaneous delayed liypersen-sitivity reaction 显示文摘 | Lewis RE Buchsbaum M Whitaker D | 1989 | Invest Dermatol1989，93，5： | 1 |
| 13 | Comparison and predictors of rash associated with 15 antiepileptic drugs显示文摘 | Arif H Buchsbaum R Weintraub D | 2007 | Neurology2007，68，20： | 1 |
| 14 | Global changes in cerebral white matter diffusion in normal aging显示文摘 | Nusbaum AO Tang CY Buchsbaum MS | 1999 | Proc Intl Soc Magn Reson Med1999，7，： | 1 |
| 15 | Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex 显示文摘 | Wu J Buchsbaum MS Gillin JC | 1999 | Am J Psychiatry1999，156，3： | 1 |
| 16 | Detection and measurement of in vitro gene transfer by gamma camera imaging显示文摘 | Chaudhuri TR Buchsbaum DJ | 2001 | Gene Ther2001，8，4： | 1 |
| 17 | Sexuality and sexual activity in women after colpocleisis 显示文摘 | Duecy EE McNanley AR Buchsbaum GM | 2009 | Int Urogy- necol J Pelvic Floor Dysfunct2009，20，： | 1 |
| 18 | Approaches to enhance cancer radiotherapy employing gene transfer methods 显示文摘 | Buchsbaum DJ Raben D Stackhouse MA | 1996 | Gene Ther1996，3，12： | 1 |
| 19 | Regulation of p70 S6 kinase by complex formation between the Racguanine nucleotide exchange factor(Rac2GEF) Tiaml and the scaffold spinophilin显示文摘 | Buchsbaum R J Connolly B A Feig L A | 2003 | Biol Chem2003，278，18： | 1 |
| 20 | Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging 显示文摘 | Haznedar MM Buchsbaum MS Wei TC | 2000 | Am J Psychiatry2000，157，12： | 1 |
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