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	题名	作者	年代	出处	被引量
1	Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.	Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong	2017	World Journal of Gastroenterology2017，23，6：	2
2	MR Angiography of the Intracranial Venous System显示文摘	Liauw L van Buchem MA Spilt A	2000	Radiology2000，214，3：	1
3	Migraine as a risk factor for subclinical brain lesions显示文摘	Kruit MC van Buchem MA Hofman PAM		0，，：	1
4	Cerebral mierobleeds in CADASIL显示文摘	Lesnik Oberstein SA van den Boom R van Buchem M	2001	Neurology2001，57，6：	1
5	Susac syndrome: a report of hmr eases and a review of the literature显示文摘	van der Kooij SM van Buchem MA Overbeek OM	2015	Neth J Med2015，73，1：	1
6	Migraine as a risk factor for subclinical brain lesions显示文摘	Kruit M C van Buchem M A Hofman P A	2004	JAMA2004，291，：	1
7	Magnetization transfer: appl icat ions in neuroradiology显示文摘	van Buchem MA	1999	J Comput Assist Tomogr1999，231，：	1
8	显示文摘	Van der Wel MC Lammers GJ van Buchem MA	2007	Ned Tijdschr Geneeskd2007，151，12：	1
9	Cerebral microbleeds in CADASIL显示文摘	Oberstein SAJ Boom R Buchem MA	2001	Neurology2001，57，：	1
10	MR angiography of the intracranial venous system 显示文摘	Liauw L Van Buchem MA Spilt A	2000	Radiology2000，214，3：	1
11	MR angiography of the intracranial venous system 显示文摘	Liauw L van Buchem MA Spilt A	2002	Radiology2002，214，3：	1
12	MR angiography of the intracranial venous system 显示文摘	Liauw L van Buchem MA Spilt A	2002	Radiology2002，214，：	1
13	Nitric oxide medi-ates hypoxia-induced cerebral vasodilation in humans显示文摘	VanMil AH Spilt A Van Buchem MA	2002	J ApplPhysiol2002，92，3：	1
14	MR angiography of the intracranial venous system显示文摘	Liauw L van Buchem MA Spilt A	2000	Radiology2000，214，2：	1
15	Migraine is associated with an increased risk of deep white matter lesions,subclinical pos-terior circulation infarcts and brain iron accumulation:the popula-tion-based MRI CAMERA study显示文摘	Kruit MC van Buchem MA Launer LJ		0，，：	1
16	Experimental basis of per- cutaneous laser discdecompression ( PLDD ) : a review of literature 显示文摘	Schenk B Brouwer PA van Buchem MA	2006	Lasers Med Sci2006，21，4：	1
17	Is there a way to predict outcome in (near)term neonates with hypoxic-ischemic encephalopathy based on MR imaging显示文摘	Liauw L van der Grond J van den Berg-Huysmans AA Laan LA van Buchem MA van Wezel-Meijler G		0，，09：	1
18	Arterial stiffness,pres-sure and flow pulsatility and brain structure and function:the Age ,Gene/ Environment Susceptibility-Reykjavik study显示文摘	Mitchell GF van Buchem MA Sigurdsson S	2011	Brain2011，34，1：	1
19	Functional brain connectivity at rest changes after working memory training显示文摘	Dietsje D. Jolles Mark A. van Buchem Eveline A. Crone Serge A.R.B. Rombouts	2011	Hum Brain Mapp2011，，2：	1
20	MR angiography of intracranial venous system显示文摘	Liauw L Van Buchem MA Spilt A	2002	Radiology2002，214，3：	1

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