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| 1 | Preservation solutions used during abdominal transplantation:Current status and outcomes显示文摘Organ preservation remains an important contributing factor to graft and patient outcomes. During donor organ procurement and transportation, cellular injury is mitigated through the use of preservation solutions in conjunction with hypothermia. Various preservation solutions and protocols exist with widespread variability among transplant centers. In this review of abdominal organ preservation solutions, evolution of transplantation and graft preservation are discussed followed by classification of preservation solutions according to the composition of electrolytes, impermeants, buffers, antioxidants, and energy precursors. Lastly, pertinent clinical studies in the setting of hepatic, renal, pancreas, and intestinal transplantation are reviewed for patient and graft survival as well as financial considerations. In liver transplants there may be some benefit with the use of histidine-tryptophan-ketoglutarate(HTK) over University of Wisconsin solution in terms of biliary complications and potential cost savings. Renal grafts may experience increased initial graft dysfunction with the use of Euro-Collins thereby dissuading its use in support of HTK which can lead to substantial cost savings. University of Wisconsin solution and Celsior are favored in pancreas transplants given the concern for pancreatitis and graft thrombosis associated with HTK. No difference was observed with preservation solutions with respect to graft and patient survival in liver, renal, and pancreas transplants. Studies involving intestinal transplants are sparse but University of Wisconsin solution infused intraluminally in combination with an intra-vascular washout is a reasonable option until further evidence can be generated. Available literature can be used to ameliorate extensive variation across centers while potentially minimizing graft dysfunction and improving associated costs. | Nicholas Latchana Joshua R Peck Bryan A Whitson Mitchell L Henry Elmahdi A Elkhammas Sylvester M Black | 2015 | World Journal of Transplantation2015，5，4： | 5 |
| 2 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 3 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 4 | Intestinal stem cells and the colorectal cancer microenvironment显示文摘Colorectal cancer(CRC)remains a highly fatal condition in part due to its resilience to treatment and its propensity to spread beyond the site of primary occurrence.One possible avenue for cancer to escape eradication is via stem-like cancer cells that,through phenotypic heterogeneity,are more resilient than other tumor constituents and are key contributors to cancer growth and metastasis.These proliferative tumor cells are theorized to possess many properties akin to normal intestinal stem cells.Not only do these CRC'stem'cells demonstrate similar restorative ability,they also share many cell pathways and surface markers in common,as well as respond to the same key niche stimuli.With the improvement of techniques for epithelial stem cell identification,our understanding of CRC behavior is also evolving.Emerging evidence about cellular plasticity and epithelial mesenchymal transition are shedding light onto metastatic CRC processes and are also challenging fundamental concepts about unidirectional epithelial proliferation.This review aims to reappraise evidence supporting the existence and behavior of CRC stem cells,their relationship to normal stem cells,and their possible dependence on the stem cell niche. | Bryan A Ong Kenneth J Vega Courtney W Houchen | 2014 | World Journal of Gastroenterology2014，20，8： | 2 |
| 5 | Transforming the cost of solar-to-electrical energy conversion: Integrating thin-film GaAs solar cells with non-tracking mini-concentrators显示文摘Practical solar energy solutions must not only reduce the cost of the module,but also address the substantial balance of system costs.Here,we demonstrate a counter-intuitive approach based on gallium arsenide solar cells that can achieve extremely low-cost solar energy conversion with an estimated cost of only 3% that of conventional gallium arsenide solar cells using an accelerated,non-destructive epitaxial lift-off wafer recycling process along with a lightweight,thermoformed plastic,truncated mini-compound parabolic concentrator that avoids the need for active solar tracking.Using solar cell/concentrator assemblies whose orientations are adjusted only a few times per year,the annual energy harvesting is increased by 2.8 times compared with planar solar cells without solar tracking.These results represent a potentially drastic cost reduction in both the module and the balance of system costs compared with heavy,rigid conventional modules and trackers that are subject to wind loading damage and high installation costs. | Kyusang Lee Jaesang Lee Bryan A Mazor Stephen R Forrest | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 6 | Genetic algorithms for reliability-based optimization of water distribution systems显示文摘 | Bryan A Tolson Holger R Maierl Angus R Simpson | 2005 | Journal of Water Resources and Management2005，26，6： | 1 |
| 7 | Immunohistichemical localization of endothelial nitric oxide synthase in human testis,epididymis,and vas deferens suggests a possible role for nitric oxide in spermatogenesis,sperm maturation,and programmed cell death 显示文摘 | Zini A O'Bryan M K Magid M S etal | 1996 | Bio Reprod1996，55，： | 1 |
| 8 | Nitric oxide synthase activi ty in human seminal plasma 显示文摘 | Zini A O'Bryan M K Schlegel P N | 2001 | Urology2001，58，1： | 1 |
| 9 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 10 | Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicityimplications for therapeutic targeting of Nrf2显示文摘 | Olayanju A Copple IM Bryan HK Edge GT Sison RL Wong MW | 2015 | Free Radic Biol Med2015，78，： | 1 |
| 11 | Strategic type,Market Orientation,and the balance between adaptability and adaptation显示文摘 | Bryan A lukas | 1999 | Journal of business research1999，45，： | 1 |
| 12 | Microsatellite analysis of endometriosis reveals loss of heterozygosity at candidate overian tumor suppressor gene loci显示文摘 | Jiang X Hitchcock A Bryan EJ | 1996 | Cancer Res1996，56，15： | 1 |
| 13 | The Effect of Market Orientation on Product Innovation 显示文摘 | Bryan A Lukas O C Ferrell | 2000 | Academy of Marketing Science2000，28，1： | 1 |
| 14 | Design and Synthesis of Biologically Active Peptides: Acids Can Modulate Activity of Synthetic Peptides 显示文摘 | Bryan A Joseph L Bennett J A | 2011 | Peptides2011，32，12： | 1 |
| 15 | Rho kinase proteins-pleiotropic modulators of cell survival and apoptosis显示文摘 | STREET C A BRYAN B A | | 0，，11： | 1 |
| 16 | Metal - catalysed radical cyclisations leading to N - heterocycles : new approaches to gabapentin and pulchellalactam显示文摘 | Bryans J S Chessum N E A Huther N | 2003 | Tetrahedron2003，59，33： | 1 |
| 17 | Nitric oxide synthase activity in human seminal plasma 显示文摘 | Zini A O'bryan MK Schlegel PN | 2001 | Urology2001，58，1： | 1 |
| 18 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 19 | Herbicide resistance: impact and management 显示文摘 | Jutsum A R Preston C Bryan I B | 1997 | Advances in Agronomy1997，58，： | 1 |
| 20 | Repression of an altemative mechanism for lengthening of telomeres in somatic cell hybrids 显示文摘 | Perrem K Bryan T M Englezou A | 1999 | Oncogene1999，18，： | 1 |
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