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| 1 | Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects显示文摘A gastrointestinal(GI) transmural defect is defined as total rupture of the GI wall,and these defects can be divided into three categories: perforations,leaks,and fistulas. Surgical management of these defects is usually challenging and may be associated with high morbidity and mortality rates. Recently,several novel endoscopic techniques have been developed,and endoscopy has become a firstline approach for therapy of these conditions. The use of endoscopic vacuum therapy(EVT) is increasing with favorable results. This technique involves endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. This promotes healing via five mechanisms,including macrodeformation,microdeformation,changes in perfusion,exudate control,and bacterial clearance,which is similar to the mechanisms in which skin wounds are treated with commonly employed wound vacuums. EVT can be used in the upper GI tract,small bowel,biliopancreatic regions,and lower GI tract,with variable success rates and a satisfactory safety profile. In this article,we review and discuss the mechanism of action,materials,techniques,efficacy,and safety of EVT in the management of patients with GI transmural defects. | Diogo Turiani Hourneaux de Moura Bruna Furia Buzetti Hourneaux de Moura Michael A Manfredi Kelly E Hathorn Ahmad N Bazarbashi Igor Braga Ribeiro Eduardo Guimaraes Hourneaux de Moura Christopher C Thompson | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 6 |
| 2 | Idiopathic acute transverse myelitis:a clinical study and prognostic markers in 45 cases显示文摘 | Bruna J Martinez-Yelamos S Martinez-Yelamos A | 2006 | Mult Scler2006，12，2： | 1 |
| 3 | Changes in the components of dry-fermented sausages during ripening显示文摘 | ORDNEZ J A HIEERO E M BRUNA J M | 1999 | Critical Reviews in Food Science and Nutrition1999，39，4： | 1 |
| 4 | Modulation of PPAR activity via phosphorylation显示文摘 | KATHERINE A BRUNAS JOHN P | 2007 | Biochimica et Biophysica Acta2007，1771，8： | 1 |
| 5 | Neurotoxicity induced by antineoplastic proteasome inhibitors显示文摘 | A1é A Bruna J Navarro X | 2014 | Neurotoxicology2014，10，14： | 1 |
| 6 | Concomi- tant chemoradiation in patients with cervix cancer显示文摘 | Haie-Meder C de Crevoisier R Bruna A | 2005 | Bull Cancer2005，92，12： | 1 |
| 7 | High TGFbeta-Smadactivity confers poor prognosis in glioma patients andpromotes cell proliferation depending on the methylation ofthe PDGF-B gene显示文摘 | Bruna A Darken R S Rojo F | 2007 | Cancer Cell2007，11，2： | 1 |
| 8 | Changes in the components of dry-fermented sausages during ripening显示文摘 | ORD6/qEZ J A HIERRO E M BRUNA J M | 1999 | Critical Reviews in Food Science and Nutrition1999，39，4： | 1 |
| 9 | Chemotherapy-induced peripheral neurotoxicity(CIPN):an update显示文摘 | Argyriou A A Bruna J Marmiroli P | 2012 | Crit Rev Oncol Hematol2012，82，1： | 1 |
| 10 | High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene 显示文摘 | Bruna A Darken RS Rojo F | 2007 | Cancer Cell2007，11，2： | 1 |
| 11 | Changes in the components of dry-fermented sausages during ripening显示文摘 | Ordónez J A Hierro E M Bruna J M | 1999 | Critical Reviews in Food Science and Nutrition1999，39，4： | 1 |
| 12 | Changes in thecomponents of dry - fermented sausages during ripening 显示文摘 | Ordonez J A Hierro E V Bruna J M | 1999 | Critical Reviews in Food Science and Nutrition1999，39，4： | 1 |
| 13 | Changes in the components of dry-fermented sausages during ripening显示文摘 | Ordonez J A Hierro E M Bruna J M | | 0，，04： | 1 |
| 14 | Concomitantchemoradiation in patients with cervix cancer显示文摘 | Haie-Meder C de Crevoisier R Bruna A | 2005 | Bull Cancer2005，92，12： | 1 |
| 15 | Concomitant chemoradiation in patients with cervix cancer显示文摘 | HaieMeder C de Crevoisier R Bruna A | 2005 | Bull Cancer2005，92，12： | 1 |
| 16 | Changes in the components of dry-fermented sausages during ripening显示文摘 | ORDONEZ J A HIERRO E M BRUNA J M | 1999 | Critical Re- views in Food Science and Nutrition1999，39，4： | 1 |
| 17 | Changes in the components of dry-fermented sausages during ripening 显示文摘 | Ordonez J A Hierro E M Bruna J M | 1999 | Critical Reviews in Food Science and Nutrition1999，39，： | 1 |
| 18 | Changes in the components of dry-fermented sausages during ripening显示文摘 | ORD(O)(N) EZ J A HIERRO E M BRUNA J M | 2010 | Food Science and Nutrition2010，39，4： | 1 |
| 19 | Signal recovery from poo- ing representations显示文摘 | BRUNA J SZLAM A LECUN Y | 2013 | Eprint Arxiv2013，，： | 1 |
| 20 | First quantization matrix estimation from double compressed JPEG images显示文摘 | GALVAN F PUGLISI G BRUNA A R BATTIATO S | 2014 | IEEE Transactions on Information Forensics and Security2014，9，8： | 1 |
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