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| 1 | Biogeochemical cycling of metals impacting by microbial mobilization and immobilization显示文摘Microbial mobilization and immobilization processes can affect the bioavailability and mobility of metals thereby influencing their toxicity and can therefore be utilized to treat solid and liquid wastes contaminated by metals. However, the microbial mobilization and immobilization of metals depends on the microbial metabolism, the environment conditions. In this review, mobilization and immobilization of metals are discussed with regard to the presence and function of involved microorganisms and in relation to applications such as bioleaching. Furthermore, the biosorption process is evaluated as a possible approach for microbial immobilization of metal on the basis of four mechanisms:(1) physical adsorption,(2) ion exchange,(3) complexation, and(4) microprecipitation. In addition, sulfide precipitation by sulfate reducing bacteria was included as an example of an application of microbial immobilization. Based on the evaluation and recommendations in this paper, bioremediation strategies for metals can be improved thus increasing the opportunity for field applications. | Ran Jing Birthe V.Kjellerup | 2018 | Journal of Environmental Sciences2018，30，4： | 8 |
| 2 | 639例出生缺陷监测尸检中所见畸形的分析显示文摘从北京市64所医院出生缺陷监测的693例尸检的分析:1.尸检畸形发生率为42.28%,其中致死性畸形占70.99%;非致死性畸形占29.01%。2.293例中有216种畸形,807畸次。3.常见畸形部位依次为神经、运动、消化、五官、循环、泌尿、呼吸和生殖系统。4.最常见的畸形依次为肢体畸形,先天性脑积水、开放性脊柱裂、无脑儿和肺发育不良。 | Leading group of birth defect monitoring in Beijing | 1989 | 北京医学1989，11，5： | 5 |
| 3 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019，，4： | 3 |
| 4 | Construction of sperm-specific lactate dehydrogenase DNA vaccine and experimental study of its immuno-contraceptive effect on mice显示文摘Lactate dehydrogenase C4 (LDHC4) is a key enzyme for sperm metabolism. It is distributed specifically in testis and is highly immunogenic. In this study, two DNA vaccines pVAX1-hLDHC and pVAX1-mLDHC were constructed by inserting coding sequences of human and mice LDHC4 into the eukaryotic ex-pression vector pVAX1. The production of LDHC4 specific antibodies was induced in the sera of vac-cinated mice and the reproductive tract secretions of vaccinated female mice through immunization by mucosal surface instillation. Furthermore, the antibody titer increased with the times of immunization. In the mating experiment, the number of newborns of the vaccinated mice reduced significantly and some immunized female mice even lost the ability to bear any offsprings, suggesting that the difference between the immunized and control mice was statistically significant. Sperm agglutination analysis indicated that both the antisera from immunized mice and the reproductive tract secretions of vacci-nated female mice could agglutinate normal sperms. Results of immunohistochemistry showed that the antibodies present in the sera of immunized mice and the reproductive tract secretions of vaccinated female mice could specifically react with LDHC4 antigen, which mainly locates in the cytoplasm, acrosome membrane externa and acrosome capsule of the sperm. Taken together, our results indicated that the constructed contraceptive DNA vaccines did yield immunocontraceptive effects on mice and this would enable clinical trials in near future. | CHEN Yong*, ZHANG Duo*, XIN Na, XIONG YongZhong, CHEN Ping, LI Bo, TU XiangDong & LAN FengHua Research Laboratory of Medical Genetics, PLA Institute of Technology for Birth Control, Fetal Health and Child Growth, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China | 2008 | Science China(Life Sciences)2008，51，4： | 3 |
| 5 | Common bile duct injuries during laparoscopic cholecystectomy that result in litigation显示文摘 | B. J. Carroll M. Birth E. H. Phillips | 1998 | Surgical Endoscopy1998，，4： | 3 |
| 6 | Common bile duct injuries during laparoscopic cholecystectomy that result in litigation 显示文摘 | Carroll BJ Birth M Phillps EH | 1998 | Surg Endosc1998，12，： | 1 |
| 7 | Laparoscopic ultrasound navigation in liver surgery: technical aspects and accuracy显示文摘 | M. Kleemann P. Hildebrand M. Birth H. P. Bruch | 2006 | Surgical Endoscopy2006，，5： | 1 |
| 8 | Vascular closure staples--a new technique for biliary reconstruction:Prospective randomized comparison with manual suture in an animal model显示文摘 | Birth M Markert U Strik M | 2002 | Transplantation2002，73，1： | 1 |
| 9 | An optical method for estimating papaya maturity 显示文摘 | Birth G S Dull G G Magee J B | 1984 | J Am Sot Hortic Sci1984，109，： | 1 |
| 10 | Renault Research 显示文摘 | Birth S | 2000 | Automotive Engineering International2000，，3： | 1 |
| 11 | Boothroyd C 显示文摘 | Smith CA de Lacey S Chapman M Acupuncture to im- prove live birth rates for women undergoing in vitro fertilization : a protocol for a randomized controlled trial | 2012 | Trials2012，13，： | 1 |
| 12 | Minimal hepatic encephalopathy impairs fitness to drive 显示文摘 | Christian W Horst K Birthe P | 2004 | Hepatology2004，39，3： | 1 |
| 13 | Nondestructive detection of water core in delicious apples显示文摘 | Birth G S Olsen K L | 1964 | Proc Amer Soc Hort Sci1964，85，： | 1 |
| 14 | The light scattering properties of foods显示文摘 | Birth G S | 1978 | Journal of Food Science1978，43，3： | 1 |
| 15 | Mannose-binding lectin gene polymorphisms and hepatitis B virus infection in Vietnamese patients显示文摘 | Song LH Birth VQ Duy DN | 2003 | Mutat Res2003，522，12： | 1 |
| 16 | Low-temperature Growth of ZnO Epitaxial Films by Metal Organic Chemical Vapor Deposition 显示文摘 | Zhang B P Birth N T Wakatsuki K | 2004 | A Appl Phys2004，78，： | 1 |
| 17 | A meta-analysis显示文摘 | De Kieviet JF Piek JP Aarnoudse-Moens CS :Motor development in very preterm and very low-birth-weight children from birth to adolescence | 2009 | JAMA2009，302，： | 1 |
| 18 | Patient satisfaction with postoperative pain management-effect of preop-erative factors显示文摘 | Leila Niemi-Murola Reino Poybia Birthe Rben | 2007 | Pain Management Nursing2007，8，3： | 1 |
| 19 | Measuring the color of growingturf with a reflectance spectroradiometer 显示文摘 | BIRTH G S MCVEY G | 1968 | Agron J1968，60，6： | 1 |
| 20 | Common bile duct injuries during laparoseopic eholeeysteetomy that result in litigation显示文摘 | Carroll BJ Birth M Phillips EH | 1998 | Surg Enclose1998，12，4： | 1 |
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