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| 1 | Role of micronutrients in staging of nonalcoholic fatty liver disease:A retrospective cross-sectional study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD) presents high incidence throughout the world and has been progressively increasing in prevalence. This disease has a heterogeneous natural history, including simple steatosis, nonalcoholic steatohepatitis(NASH), and cirrhosis. The factors that determine its evolution to more severe forms of the disease are still poorly understood, and micronutrients with antioxidant potential may be involved in the pathophysiology of the disease.AIM To evaluate the relationship between serum levels of micronutrients and the severity of NAFLD.METHODS A retrospective, observational and cross-sectional study was conducted. This study included all patients undergoing bariatric surgery who experienced liver biopsy during the procedure, and had serum levels of micronutrients(vitamin D,vitamin B12, zinc, iron, and magnesium), which was assessed in a preoperative evaluation conducted at a reference center in southern Brazil.RESULTS A total of 614 patients were analyzed, of which 93% had steatosis, 70.7% had NASH, and 49.3% had some degree of fibrosis. Serum levels of vitamin D were negatively correlated with the severity of steatosis and NASH, and serum levels of vitamin B12 were positively correlated with the severity of steatosis and fibrosis. The other micronutrients showed no association with NAFLD staging.CONCLUSION Serum levels of vitamin D are inversely related to the severity of steatosis and NASH, and serum levels of vitamin B12 are higher in more advanced stages of simple steatosis and liver fibrosis. Serum levels of zinc, iron, and magnesium were not associated with NAFLD severity. | Franciele Sabadin Bertol Bruna Araujo Brunno Brochado Jorge Natalino Rinaldi Luiz Alberto De Carli Cristiane Valle Tovo | 2020 | World Journal of Gastrointestinal Surgery2020，12，6： | 2 |
| 2 | Transcriptional control of the RECK metastasis angiogenesis suppressor gene 显示文摘 | Sasahara R M Brochado S M Takahashi C | 2002 | Canecr Detect Prey2002，26，6： | 1 |
| 3 | Methylenetetrahydrofolate reductase gene polymorphism and serum homocysteine levels in nonalco- holic fatty liver disease 显示文摘 | Franco Brochado M J Domenici F A Candolo Martinel- li A D | 2013 | Ann Nutr Metab2013，63，3： | 1 |
| 4 | Transcriptional control of the RECK metastasis/angiogenesis suppressor gene显示文摘 | Sasahara RM Brochado SM Takahashi C | 2002 | Cancer Detect Prey2002，26，6： | 1 |
| 5 | Transcriptional control of the RECK metastasis /angiogenesis suppressor gene显示文摘 | SASAHARA R M BROCHADO S M TAKAHASHI C | 2002 | Cancer Detect Prev2002，26，6： | 1 |
| 6 | Flavonol robinobiosides and turinosides from Alternanthera brasiliana(Amaranthaceae) and their effects on lymphocyte proliferation in vitro显示文摘 | Claudia De O Brochado Ana P De Almeida Beatriz P Barreto | 2003 | Journal of the Brazilian Chemical Society2003，14，3： | 1 |
| 7 | Transcriptional cont rol of t he RECK metastasis / angiogenesis suppressor gene显示文摘 | Sasahara M Brochado M Ta Kahashi | | 0，，06： | 1 |
| 8 | lnfluence of chemical treatment on quality of cut apple( cv Jonagored) 显示文摘 | Rocha A M C N Brochado C M Morais A M M B | 1998 | Food Qual1998，21，： | 1 |
| 9 | Meta -analysis of infrapopliteal angioplasty for chronic critical limb ischemia显示文摘 | Romiti M Albers M Brochado -Nero FC | 2008 | J Vasc Surg2008，47，5： | 1 |
| 10 | Meta-analysis of infrapopliteal angioplasty for chronic critical limb ischemia显示文摘 | Romiti M Albers M Brochado Neto F C | 2008 | J Vasc Surg2008，47，5： | 1 |
| 11 | Transcriptional contr --ol of the RECK metastasis/angiogenesis suppressor gene 显示文摘 | Sasahara RM Brochado SM Takahashi C | 2002 | Cancer Detect Prey2002，26，6： | 1 |
| 12 | Flavonol robinobiosides and turinosides from Alternanthera brasiliana(Amaranthaceae)and their effects on lymphocyte proliferation in vitro显示文摘 | Claudia De O Brochado Ana P De Almeida Beatriz P Barreto | 2003 | Journal of the Brazilian Chemical Society2003，14，3： | 1 |
| 13 | Impact of low cost strength training of dorsi‐and plantar flexors on balance and functional mobility in institutionalized elderly people显示文摘 | Ribeiro F Teixeira F Brochado G | 2009 | Geriatrics&gerontology international2009，9，1： | 1 |
| 14 | Peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms in nonalcoholic fatty liver disease: A study in Brazilian patients显示文摘 | Fernanda Aparecida Domenici Maria José Franco Brochado Ana de Lourdes Candolo Martinelli Sergio Zucoloto Selma Freire de Carvalho da Cunha Helio Vannucchi | 2013 | Gene2013，，： | 1 |
| 15 | Peroxi- some proliferator-activated receptors alpha and gamma2 polymorphisms in nonalcoholic fatty liver disease: a study in Brazilian patients显示文摘 | Domenici FA Brochado MJ Martinelli AL | 2013 | Gene2013，529，2： | 1 |
| 16 | Airport regulation in Europe:Is there need for a European Observatory?显示文摘 | MARQUES R C BROCHADO A | 2008 | Transport Policy2008，15，： | 1 |
| 17 | Transcriptional con- trol of the RECK metastasis/angiogenesis suppressor gene 显示文摘 | Sasahara RM Brochado SM Takahashi C | 2002 | Cancer Detect Prev2002，26，6： | 1 |
| 18 | Influence of chemical treatment on quality of cut apple显示文摘 | Rocha A Brochado C M Morais A | 1998 | J Food Qual1998，21，1： | 1 |
| 19 | Transcriptional control of the RECK metastasis/angiogenesis suppressor gene显示文摘 | BROCHADO SM TAKAHASHI C | 2002 | Cancer Detect Prev2002，26，6： | 1 |
| 20 | Transcriptional con- trol of the RECK metastasis/angiogenesis suppressor gene 显示文摘 | Sasahara RM Brochado SM Takahashi C | 2002 | Cancer Detect Prey2002，26，6： | 1 |
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