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| 1 | Bile-acid-induced cell injury and protection显示文摘Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. Several pathways are involved in triggering hepatocyte apoptosis. Toxic BAs can activate hepatocyte death receptors directly and induce oxidative damage, thereby causing mitochondrial dysfunction, and induce endoplasmic reticulum stress. When these compounds are taken up and accumulate inside biliary cells, they can also cause apoptosis. Regarding extrahepatic tissues, the accumulation of BAs in the systemic circulation may contribute to endothelial injury in the kidney and lungs. In gastrointestinal cells, BAs may behave as cancer promoters through an indirect mechanism involvingoxidative stress and DNA damage, as well as acting as selection agents for apoptosis-resistant cells. The accumulation of BAs may have also deleterious effects on placental and fetal cells. However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity, due in part to an enhancement in glutathione levels; and the inhibition of liver cell apoptosis. Other natural BAs or their derivatives, such as cholyl-N- methylglycine or cholylsarcosine, have also aroused pharmacological interest owing to their protective properties. | Maria J Perez Oscar Briz | 2009 | World Journal of Gastroenterology2009，15，14： | 53 |
| 2 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 3 | Consumer awareness of organic products in Spain: An application of multinominal logit models显示文摘 | T. Briz R.W. Ward | 2008 | Food Policy2008，，3： | 2 |
| 4 | Consumer Awareness of Organic Products in Spain: An Application of Muhinominal Logit Models 显示文摘 | Briz T Ward R W | 2009 | Food Policy2009，34，3： | 1 |
| 5 | Consumer awareness of organic products in Spain: An application of multinominal logit models 显示文摘 | Briz T Ward R W | 2009 | Food Policy2009，34，3： | 1 |
| 6 | Excretion of foetal bilirubin by the rat placenta-maternal liver tandem 显示文摘 | Briz O Macias RI Serrano MA | 2003 | Placenta2003，24，5： | 1 |
| 7 | Sensorless control of three-pole active magnetic bearings using saliencytracking-based methods显示文摘 | García P Guerrero J M Briz F | | 0，，04： | 1 |
| 8 | Characterization of WIF- B9/R cells as an in vitro model with hepatocyte-like polarity and enhanced expression of canalicular ABC transporters involved in phase Ⅲ of hepatic detoxification 显示文摘 | Briz O Cassio D Blazquez A G | 2007 | Toxicology2007，232，12： | 1 |
| 9 | Video thoracoscopy expedites the diagnosis and treatment of penetrating diaphragmatic injuries显示文摘 | Briz JE Carrillo EH | 2001 | Surg Endosc2001，15，： | 1 |
| 10 | Role of organic anion-trans- porting polypeptides,OATP-A,OATP-C and OATP-8,in the hu- man placenta-maternal liver tandem excretory pathway for foetal bilirubin 显示文摘 | Briz O Serrano MA MacIas RI | 2003 | Biochem J2003，371，3： | 1 |
| 11 | Impact of saturation,current command selection,and leakage flux on the performance of sensorless-controlled three-pole active magnetic bearings显示文摘 | Garcia P Guerrero J M Briz F | | 0，，04： | 1 |
| 12 | Analysis and De- sign of Current Regulators Using Complex Vectors 显示文摘 | Briz F Degner M W Lorenz R D | 2000 | IEEE Transactions on Industrial Applications2000，36，3： | 1 |
| 13 | Analysis and Design of current regulators using complex vectors 显示文摘 | FERNANDO Briz MICHAEL W Degner ROBERT D Lorez | 2000 | IEEE Transactions on industrial Applications (S0093-9994)2000，36，6： | 1 |
| 14 | Analysis and design of current regulators using complex vectors显示文摘 | Briz F Degner M W Lorenz R D | 2000 | IEEE Transactions on Industry Applications2000，36，3： | 1 |
| 15 | Dynamic behavior of current controllers for selective harmonic compensation in three-phase active power filters 显示文摘 | Briz F Garcia P Degner M W | 2013 | IEEE Trans on Indus- try Applications2013，49，3： | 1 |
| 16 | Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum ( 11 ) and cis- diammine-bisursodeoxycholate-platinum ( 11 ) toward liver cells 显示文摘 | Briz O Serrano MA Rebollo N | 2002 | Mol Pharmacol2002，61，4： | 1 |
| 17 | Potential rote of trans - inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy显示文摘 | Vallejo M Briz O Serrano MA | 2006 | J Hepatol2006，44，6： | 1 |
| 18 | Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8 in the human placenta-maternal liver tandem excretory pathway for fetal bilirubin 显示文摘 | BRIZ O SERRANO M A MACIAS R I | 2003 | Biochem J2003，371，3： | 1 |
| 19 | Molecular bases of the fetal liver-placenta-maternal liver excretory pathway for cholephilic compounds显示文摘 | Marin JJ Macias RI Briz O | 2008 | Liver Int2008，28，4： | 1 |
| 20 | Molecular pathogenesis of intrahepatic cholestasis of pregnancy显示文摘 | Arrese M Macias RI Briz O | 2008 | Expert Rev Mol Med2008，10，3： | 1 |
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