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| 1 | Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease显示文摘AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission. | Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet | 2017 | World Journal of Gastroenterology2017，23，23： | 5 |
| 2 | Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders显示文摘AIM To investigate compliance with transanal irrigation(TAI) one year after a training session and to identify predictive factors for compliance.METHODS The compliance of one hundred eight patients [87 women and 21 men; median age 55 years(range 18-83)] suffering from constipation or fecal incontinence(FI) was retrospectively assessed. The patients were trained in TAI over a four-year period at a single institution. They were classified as adopters if they continued using TAI for at least one year after beginning the treatment or as non-adopters if they stopped. Predictive factors of compliance with TAI were based on pretreatment assessments and trainingprogress. The outcomes of the entire cohort of patients who had been recruited for the TAI treatment were expressed in terms of intention-to-treat.RESULTS Forty-six of the 108(43%) trained patients continued to use TAI one year after their training session. The patients with FI had the best results, with 54.5% remaining compliant with TAI. Only one-third of the patients who complained of slow transit constipation or obstructed defecation syndrome continued TAI. There was an overall discontinuation rate of 57%. The most common reason for discontinuing TAI was the lack of efficacy(41%). However, 36% of the patients who discontinued TAI gave reasons independent of the efficacy of the treatment such as technical problems(catheter expulsion, rectal balloon bursting, instilled water leakage or retention, pain during irrigation, anal bleeding, anal fissure) while 23% said that there were too many constraints. Of the patients who reported discontinuing TAI, the only predictive factor was the progress of the training(OR = 4.9, 1.3-18.9, P = 0.02).CONCLUSION The progress of the training session was the only factor that predicted patient compliance with TAI. | Clémence Bildstein ChloéMelchior Guillaume Gourcerol Estelle Boueyre Valérie Bridoux Eric Vérin Anne-Marie Leroi | 2017 | World Journal of Gastroenterology2017，23，11： | 3 |
| 3 | Evaluation of selective defunctioning stoma after low anterior resection for rectal cancer显示文摘 | B. Lefebure J. J. Tuech V. Bridoux B. Costaglioli M. Scotte P. Teniere F. Michot | 2008 | International Journal of Colorectal Disease2008，，3： | 2 |
| 4 | AL Amyloidosis 显示文摘 | Desport E Bridoux F Sirac C | 2012 | Orphanet J Rare Dis2012，7，1： | 1 |
| 5 | Heterogeneous motives and the collective creation of value显示文摘 | Bridoux F | 2011 | Academy of Management Review2011，36，4： | 1 |
| 6 | Proximal tubular dysfunction in primary Sjogren's syndrome: a clinicopathological study of 2 cases显示文摘 | Bridoux F Kyndt X Abou-Ayache R | 2004 | Clin Nephrol2004，61，： | 1 |
| 7 | Evaluation of selective defunctioning stoma after low anterior resection for rectal cancer显示文摘 | Lefebure B Tuech JJ Bridoux V | 2008 | Int J Colorectal Dis2008，23，3： | 1 |
| 8 | E- valuation of selective defunctioning stoma after low anterior resec- tion for rectal cancer显示文摘 | Lefebure B Tuech J Bridoux V Costaglioli B Scotte M | 2008 | Int J Colorectal Dis2008，23，3： | 1 |
| 9 | Monoclonal gammopathy of renal significance~ when MGUS is no longer undetermined or insignificant 显示文摘 | Leung N Bridoux F Hutchison CA | 2012 | Blood2012，120，22： | 1 |
| 10 | Evaluation of selective defunctioning stoma after low anterior resection for rectal cancer 显示文摘 | Lefebure B Tucch JJ Bridoux V | 2008 | Int J Coloreotal Dis2008，23，3： | 1 |
| 11 | How I treat monoclonal gammopathy of renal significance (MGRS) 显示文摘 | Fermand JP Bridoux F Kyle RA | 2013 | Blood2013，122，35： | 1 |
| 12 | HOX genes are expressed in bovine and mouse oocytes and early embryos显示文摘 | Paul D Bridoux L Rezs?hazy R | 2011 | Molecular Reproduction and Development2011，78，6： | 1 |
| 13 | Molecular study of an IgG1κ cryoglobulin yielding organized microtubular deposits and glomerulonephritis in the course of chronic lymphocytic leukemia显示文摘 | Galea H R Bridoux F Aldigier J C | 2002 | Clin Exp Immunol2002，129，： | 1 |
| 14 | Fibrillary glomerulonephritis and immunotactoid (microtubular)glomerulopathy are associated with dinstinct immunologic features显示文摘 | Bridoux F Hugue V Coldefy O | 2002 | Kidney Int2002，62，： | 1 |
| 15 | 显示文摘 | Kyndt X Reumaux D Bridoux F | 1999 | Am J Med1999，106，： | 1 |
| 16 | Evaluation of selective defunetioning stoma after low anterior resection for rectal cancer 显示文摘 | Lefebure B Tuech JJ Bridoux V | 2008 | Int J Coloreotal Dis2008，23，3： | 1 |
| 17 | Role of the moaoclonal kappa chain V domain and revet,'silfiiity of renal damage in a lransgenic model of acquired F'anconi syndrome 显示文摘 | Sirac C Bridoux F Carrion C | 2006 | 131ood2006，108，2： | 1 |
| 18 | Prediction of hydrogen sulphide production during anaerobic digestion of organic substrates 显示文摘 | Peu P Picard S Diara A Girault R Beline F Bridoux G Dabert P | 2012 | Bioresour Technol2012，121，： | 1 |
| 19 | Lmmunoprophylaxis with basiliximab compared with antithymocyte globulin in renal transplant patients receiving MMF-containing triple therapy显示文摘 | Lebranchu Y Bridoux F Bchler M | | 0，，1： | 1 |
| 20 | Constipation in 44patients implanted with an artificial bowel sphincter显示文摘 | Gallas S Leroi A M Bridoux V | 2009 | Int J Colorectal Dis2009，24，8： | 1 |
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