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您的检索式：作者名="Brian P.Tullius"
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| 1 | Therapeutic modulation of the CD47-SIRPαaxis in the pediatric tumor microenvironment:working up an appetite显示文摘Evasion of immune surveillance is one of the hallmarks of cancer.Although the adaptive immune system has been targeted via checkpoint inhibition,many patients do not sustain durable remissions due to the heterogeneity of the tumor microenvironment,so additional strategies are needed.The innate immune system has its own set of checkpoints,and tumors have co-opted this system by expressing surface receptors that inhibit phagocytosis.One of these receptors,CD47,also known as the“don’t eat me”signal,has been found to be overexpressed by most cancer histologies and has been successfully targeted by antibodies blocking the receptor or its ligand,signal regulatory proteinα(SIRPα).By enabling phagocytosis via antigen-presenting cells,interruption of CD47-SIRPαbinding leads to earlier downstream activation of the adaptive immune system.Recent and ongoing clinical trials are demonstrating the safety and efficacy of CD47 blockade in combination with monoclonal antibodies,chemotherapy,or checkpoint inhibitors for adult cancer histologies.The aim of this review is to highlight the current literature and research on CD47,provide an impetus for investigation of its blockade in pediatric cancer histologies,and provide a rationale for new combination therapies in these patients. | Ajay Gupta Cenny Taslim Brian P.Tullius Timothy P.Cripe | 2020 | Cancer Drug Resistance2020，3，3： | 1 |
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