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| 1 | 基于微阵列芯片的比较基因组杂交技术在临床实验室产前诊断中的应用(英文)显示文摘Array-based comparative genomic hybridization (array CGH),a method used to detect gains or losses of genetic material,has recently been applied to prenatal diagnosis of genomic imbalance in the clinical laboratory setting. This new and exciting diagnostic tool represents a major technological step forward in cytogenetic testing and addresses many of the limitations of current cytogenetic methods. Conventional chromosome analysis,the current gold standard in prenatal diagnosis,focuses primarily on the detection of common aneuploidies and is limited by its capacity to detect only those copy number changes that are large enough to be microscopically visible (typically 5-6 Mb in size at the 500 band level). In contrast,array CGH analysis simultaneously evaluates regions across the entire genome and allows for detection of unbalanced structural and numerical chromosome abnormalities of less than one hundred kb. Array CGH analysis also overcomes some of the limitations of chromosome analysis,such as the requirement for cell culture and longer reporting time,by using direct uncultured fetal specimens. With many diagnostic laboratories now embracing this technology,the past year has seen tremendous growth in the use of array CGH analysis for prenatal diagnosis. This review aims to summarize array CGH methodo-logy and its current applications in prenatal diagnosis. | Amy M. BREMAN 毕为民 张秀慧 | 2009 | 北京大学学报(医学版)2009，41，4： | 2 |
| 2 | The intolerable burden of malaria: a new look at the numbers显示文摘 | Breman JG Egan A Keusch GT | 2001 | Am J Trop Med Hyg2001，64，12： | 1 |
| 3 | The intolerable burden of malaria: a new look at the numbers显示文摘 | Breman J G Egan A Keusch G T | 2001 | AmJ Trop Med Hyg2001，64，12： | 1 |
| 4 | Citrus cybrids:production by donor-recipient protoplast fusion and verification by mitochondrial DNA restriction profiles显示文摘 | Vardi A Breman A Galun E | 1987 | Theor Appl Genet1987，75，： | 1 |
| 5 | Prenatal chromosomal microarray analysis in a diagnostic lahoratory: experience with >1000 cases and review of the literature显示文摘 | Breman A Pursley AN Hixson P | 2012 | Prenat Diagn2012，32，4： | 1 |
| 6 | The ears of the hippopotamus: manifestations, de- terminants, and estimates of the malaria burden显示文摘 | Breman JG | 2001 | Am J Trop Med Hyg2001，64，12： | 1 |
| 7 | Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa显示文摘 | Gaurvika ML Nayyar Joel G Breman Paul N Newton James Herrington | 2012 | The Lancet Infectious Diseases2012，，6： | 1 |
| 8 | Rangeland productivity and exploitation in the Sahel显示文摘 | BREMAN H DE WIT C T | 1983 | Science1983，221，： | 1 |
| 9 | Rapid prenatal diagnosis using uncultured amniocyted and oligonucleotide array CGH显示文摘 | Bi W Breman AM Venable SF Eng PA | 2008 | Prenat Diagn2008，28，： | 1 |
| 10 | Rapid prenatal diagnosis usinguncultured amniocytes and oligonucleotide array CGH 显示文摘 | BiW Breman AM Venable SF | 2008 | PrenatDiagn2008，28，10： | 1 |
| 11 | Artemisinin-re- sistant malaria : research challenges, opportunities, and public health implications显示文摘 | Fairhurst R M Nayyar G M Breman J G | 2012 | Am J Trop Med Hyg2012，87，2： | 1 |
| 12 | Artemisinin-resistant malaria: research challenges, opportunities, and public health im- plications显示文摘 | Fairhurst RM Nayyar GM Breman JG | 2012 | Am J Trop Med Hyg2012，87，2： | 1 |
| 13 | Rapid prenatal diagnosis using uncultured amniocytes and oligonucleotide array CGH显示文摘 | Bi W Breman AM Venable SF | | 0，，10： | 1 |
| 14 | Artemisinin- resistant malaria: research challenges, opportunities, and public health implications 显示文摘 | Fairhurst RM Nayyar GM Breman JG et oi | 2012 | Am J Trop Med Hyg2012，87，2： | 1 |
| 15 | Ebola then and now 显示文摘 | Breman JG Johnson KM | 2014 | New England Journal of Medicine2014，371，18： | 1 |
| 16 | Pox virus dilemmas:monkey pox,smallpox and biologic terrorism显示文摘 | Breman JG Henderson DA | 1998 | N Engl J Med1998，339，： | 1 |
| 17 | Current concepts:diagnosis and management of smallpox显示文摘 | Breman JG Henderson DA | 2002 | N Engl J Med2002，346，： | 1 |
| 18 | Prenatal chromo- somal microarray analysis in a diagnostic laboratory: ex- perience with > 1 000 cases and review of the literature 显示文摘 | Breman A Pursley AN Hixson P | 2012 | Prenat Diagn2012，32，4： | 1 |
| 19 | A dualistic labor system? A critique of the ' informal sector' concept 显示文摘 | Breman J | 1976 | Economic and Political Weekly1976，，48： | 1 |
| 20 | Resistance to artemisinin-based combination therapy 显示文摘 | Breman JG | 2012 | Lancet Infect Dis2012，12，11： | 1 |
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