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	题名	作者	年代	出处	被引量
1	RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone.	Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M	2013	中国神经肿瘤杂志2013，11，1：	8
2	Numerical investigation of fan performance in a forced draft air-cooled steam condenser显示文摘	Bredell J R Kroger D G Thiart G D	2006	Applied Thermal Engineering2006，26，89：	1
3	Numerical investigation of fan performance in a forced draft air-cooled steam condenser显示文摘	Bredell J R Kroger D G Thiart G D		0，，8：	1
4	Numerical Investigation of Fan Performance in a Forced Draft Air-Cooled Steam Condenser 显示文摘	Bredell J R Kroger D G Thiart G D	2006	Applied Thermal Engineering2006，26，89：	1
5	DNA topoisomerase Ⅱ alpha predicts progression-free and overall survival in pediatric malignant non-brainstem gliomas 显示文摘	Bredel M Pollack IF Hamilton RL	2002	Int J Cancer2002，99，6：	1
6	NFKBIA deletion in glio- blastomas显示文摘	Bredel M Scholtens DM Yadav AK	2011	N Engl J Med2011，364，7：	1
7	Numerical investigation of the effect of fan performance on forced draught air-cooled heat exchanger plenum chamber aerodynamic behaviour显示文摘	Bredell G R Kroger D G Thiart G D	2006	Applied Thermal Engineering2006，，26：	1
8	High expression of DNA topoisomerase II alpha and Ki-67 antigen is associated with prolonged survival in glioblastoma patients 显示文摘	Bredel M Piribauer M Marosi C	2002	Eur J Cancer2002，38，10：	1
9	Splintless orthognathic surgery: a novel technique using patient-specific implants (PSI) 显示文摘	Gander T Bredell M Eliades T	2015	J Craniomaxillofac Surg2015，43，3：	1
10	Clinical reliability of radial forearm free-flap procedure in reconstructive head and neck surgery 显示文摘	Kruse AL Bredell MG Lubbers HT	2011	J Craniofac Surg2011，22，3：	1
11	Tumor necrosis factoralpha induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human gliobastomas 显示文摘	Bredel M Bredel C Juric D	2006	J Clin Oncol2006，24，2：	1
12	Numerical investigation of fan performance in a forced draft air- cooled steam condenser 显示文摘	Bredell J R Kroger D G Thiart G D	2006	Applied Thermal En- gineering2006，26，89：	1
13	The p21-ras signal transduction pathway and growth regulation in human high-grade gliomas显示文摘	BREDEL M POLLACK L F	1999	Brain Research Reviews1999，，23：	1
14	Tumor necrosis factor-alpha- induced protein 3 as a putative regulator of nuclear factor-kappaB- mediated resistance to O6-alkylating agents in human glioblastomas显示文摘	Bredel M Bredel C Juric D	2006	J Clin Oncol2006，24，：	1
15	Numerical investigation of fan performance in a forced draft air-cooled steam condenser显示文摘	Bredell J R Krger D G Thiart G D	2006	Applied Thermal Engineering2006，26，8：	1
16	Numeri- cal investigation of fan performance in a forced draft air'cooled steam condenser 显示文摘	Bredell J R Kroger D G Thiart G D	2006	Applied Thermal Engineering2006，26，89：	1
17	Numerical investigation into aerodynamic blade loading in large axial flow fans operating under distorted inflow conditions显示文摘	Bredell J R Kroger D G Thiart G D		0，，02：	1
18	NFKBIA deletion in glioblastomas显示文摘	BREDEL M SCHOLTENS D M YADAV AK	2011	N Engl J Med2011，364，7：	1
19	Numerical investigation of fan performance in a forced draft air-cooled steam condenser显示文摘	Bredell J R Krger D G Thiart G D	2006	Applied Thermal Engineering2006，26，8：	1
20	A network model of a cooperative genetic landscape in brain tumors显示文摘	BREDEL M SCHOLTENS DM HARSH GR	2009	JA- MA2009，302，3：	1

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