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| 1 | Early chronic obstructive pulmonary disease: Beyond spirometry显示文摘The significant healthcare burden associated with chronic obstructive pulmonary disease(COPD) is driving us to improve our understanding of the natural history of this disease. Historically, the focus has been largely centred on diagnosing and treating individuals with moderate and severe disease. However, it is now recognised that the speed of decline in lung function as measured by forced expiratory volume in 1 s occurs faster in the earlier stages of the disease process. As a result, a clearer understanding of the potential benefits of treatment in early COPD is needed. It is recognised that many patients with COPD remain undiagnosed in the community which has prompted global case-finding initiatives. In this review we discuss the difficulties in diagnosing COPD in its early stages, examine the roleof case-finding and look at the evidence for early intervention with therapeutic agents. There is a growing interest in the phenotypic variation amongst patients with COPD and we explore the role of phenotyping in early COPD and its potential benefits in providing a more individualised approach to COPD management. The majority of patients with COPD are known to die from non-respiratory causes such as cardiovascular disease. The mechanistic link is thought to relate to systemic inflammation, causing us to question whether earlier interventions could have a beneficial impact on the burden of co-morbidities for patients with COPD. | Judith A Brebner Alice M Turner | 2013 | World Journal of Respirology2013，3，3： | 5 |
| 2 | Time-resolved spectroscopy of the visible emission band in strontium titanate显示文摘 | LEONELLI R BREBNER J L | 1986 | Phys Rev B1986，33，12： | 1 |
| 3 | The effect of catch-trials on speed and accuracy among introverts and extraverts in a simple RT task 显示文摘 | Brebner J Flavel R | 1978 | Br J Psychol1978，69，1： | 1 |
| 4 | Synergistic effects of interleukin-1beta,interleukin-6,and tumor necrosis factor-alpha:central monoamine,corticosterone,and behavioral variations显示文摘 | BREBNER K HAYLEY S ZACHARKO R | 2000 | Neuropsy-chopharmacology2000，22，6： | 1 |
| 5 | Relationships between happiness and personality 显示文摘 | John Brebner Janine Donaldson Neil Kirby Lynn Ward | 1995 | Personality and Individual Differences1995，19，： | 1 |
| 6 | The importance of skin color and facial structure in perceiving and remembering others:An electrophysiological study显示文摘 | Brebner J L Krigolson O Handy T C | | 0，，： | 1 |
| 7 | A potential role for GABA agonists in the treatment of psychostimulant addiction 显示文摘 | Brebner K David C | 2002 | Mcoh Mcohol2002，37，5： | 1 |
| 8 | Fabrication of long-period optical fiber gratings by use of ion implantation显示文摘 | OHKI Y BREBNER J L | 2000 | Optic Lett2000，25，2： | 1 |
| 9 | Synergistic effects of interleukin-lbeta, interleukin-6 and tumor necrosis factor-alpha 显示文摘 | Brebner K Hayley S Zacharko R | 2000 | Neuropsychopharmacology2000，22，： | 1 |
| 10 | Intra-VTA baclofen attenuates cocaine self-administration on a progressive ratio schedule of reinforcement显示文摘 | Brebner K Phelan R Roberts DC | 2000 | Pharmacol Biochem Behav2000，66，： | 1 |
| 11 | J2ee infrastructure scalability and throughput estimation显示文摘 | BREBNER P GOSPER J | 2003 | SIGMETRICS Perform2003，31，3： | 1 |
| 12 | Relationships between Happiness and Personality 显示文摘 | Brebner J Donaldson J Kirby N | 1995 | Personality and Individual Differences1995，，19： | 1 |
| 13 | GABA modulation of cocaine self-administration显示文摘 | Roberts DC Brebner K | 2000 | Ann N Y Acad Sci2000，909，： | 1 |
| 14 | Boundary layer measurements at low speed on two wings of 45o and 55o sweep显示文摘 | Brebner G G Wyatt L A | 1961 | Ministry of Aviation Aeronautical Research Council Current Papers1961，554，： | 1 |
| 15 | 显示文摘 | Essid M Brebner J L | 1998 | Journal of Applied Physics1998，84，8： | 1 |
| 16 | 显示文摘 | Essid M Albert J Brebner J L | 1999 | Journal of Non-Crystalline Solids1999，246，： | 1 |
| 17 | Structural Properties of InAs Nanocrystals Formed by Sequential Implantation of In and As ions in Si(100)Matrix显示文摘 | Tchebotareva A Brebner J L Roorda S | 2002 | J Appl Phys2002，92，8： | 1 |
| 18 | When and how to assessfast-changing technologies:a comparative study of medical appli-cations of four generic technologies显示文摘 | Mowatt G Bower D J Brebner J A | 1997 | Health Technol Assess1997，1，14： | 1 |
| 19 | Cocaine - responsive gene expression changes in rat hippocampus 显示文摘 | Freeman WM Brebner K Lynch W J | 2001 | Neuroscience2001，108，： | 1 |
| 20 | A patient with aninborn error of vitamin B12 metabolism (cblF) detected bynewborn screening 显示文摘 | Armour CM Brebner A Watkins D | 2013 | Pediatrics2013，132，1： | 1 |
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