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| 1 | Systematic review of novel ablative methods in locally advanced pancreatic cancer显示文摘Unresectable locally advanced pancreatic cancer with or without metastatic disease is associated with a very poor prognosis.Current standard therapy is limited to chemotherapy or chemoradiotherapy.Few regimens have been shown to have a substantial survival advantage and novel treatment strategies are urgently needed.Thermal and laser based ablative techniques are widely used in many solid organ malignancies.Initial studies in the pancreas were associated with significant morbidity and mortality,which limited widespread adoption.Modifications to the various applications,in particular combining the techniques with high quality imaging such as computed tomography and intraoperative or endoscopic ultrasound has enabled real time treatment monitoring and significant improvements in safety.We conducted a systematic review of the litera-ture up to October 2013.Initial studies suggest that ablative therapies may confer an additional survival benefit over best supportive care but randomised studies are required to validate these findings. | Margaret G Keane Konstantinos Bramis Stephen P Pereira Giuseppe K Fusai | 2014 | World Journal of Gastroenterology2014，20，9： | 30 |
| 2 | Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer显示文摘瞄准:在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ,肿瘤坏死因素高山哈( TNFalpha ), peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma ),细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法:学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行,结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ,和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果:ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77, 95% CI:1.34-2.34;或 = 1.83, 95% CI:1.23-2.72;并且或 = 1.35, 95% CI:1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78, 95% CI:1.25-2.49 ) 。结论:在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些, SNP 可以改进在风险的为亚人口的适当屏蔽。 | George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli | 2006 | World Journal of Gastroenterology2006，12，31： | 16 |
| 3 | Acute mechanical bowel obstruction: Clinical presentation, etiology, management and outcome显示文摘AIM: To identify and analyze the clinical presentation, management and outcome of patients with acute mechanical bowel obstruction along with the etiology of obstruction and the incidence and causes of bowel ischemia, necrosis, and perforation. METHODS: This is a prospective observational study of all adult patients admitted with acute mechanical bowel obstruction between 2001 and 2002. RESULTS: Of the 150 consecutive patients included in the study, 114 (76%) presented with small bowel and 36 (24%) with large bowel obstruction. Absence of passage of flatus (90%) and/or feces (80.6%) and abdominal distension (65.3%) were the most common symptoms and physical finding, respectively. Adhesions (64.8%), incarcerated hernias (14.8%), and large bowel cancer (13.4%) were the most frequent causes of obstruction. Eighty-eight patients (58.7%) were treated conservatively and 62 (41.3%) were operated (29 on the first day). Bowel ischemia was found in 21 cases (14%), necrosis in 14 (9.3%), and perforation in 8 (5.3%). Hernias, large bowel cancer, and adhesions were the most frequent causes of bowel ischemia (57.2%, 19.1%, 14.3%), necrosis (42.8%, 21.4%, 21.4%), and perforation (50%, 25%, 25%). A significantly higher risk of strangulation was noticed in incarcerated hernias than all the other obstruction causes. CONCLUSION: Absence of passage of flatus and/or feces and abdominal distension are the most common symptoms and physical finding of patients with acute mechanical bowel obstruction, respectively. Adhesions, hernias, and large bowel cancer are the most commoncauses of obstruction, as well as of bowel ischemia, necrosis, and perforation. Although an important proportion of these patients can be nonoperatively treated, a substantial portion requires immediate operation. Great caution should be taken for the treatment of these patients since the incidence of bowel ischemia, necrosis, and perforation is significantly high. | Haridimos Markogiannakis Evangelos Messaris Dimitrios Dardamanis Nikolaos Pararas Dimitrios Tzertzemelis Panagiotis Giannopoulos Andreas Larentzakis Emmanuel Lagoudianakis Andreas Manouras Ioannis Bramis | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 4 | Malignant carcinoid tumor of the cystic duct:a rare cause of bile duct obstruction显示文摘BACKGROUND:Carcinoid tumors of the extrahepatic biliary tree are extremely rare malignancies,accounting for 0.2%-2%of all gastrointestinal carcinoid tumors,while carcinoids of the cystic duct are an uncommon entity and an extremely unusual cause of bile duct obstruction.METHODS:After an extensive literature review,we retrospectively analysed 61 cases of carcinoid tumor of the biliary tree as well as one additional case of a 60-yearold female with symptoms and laboratory/imaging examination findings compatible with those of a malignant biliary tract obstruction.At laparotomy,resection of the gallbladder and common bile duct was performed.Histological study revealed a well-differentiated neuroendocrine carcinoma of the cystic duct.The patient remained disease-free at 16 months.RESULTS:Our presentation is the seventh case reported in the world literature.Compared to cholangiocarcinoma,analysis of the reviewed group indicates an increased incidence of extrahepatic carcinoid tumors in younger persons along with a slight female predominance.Statistically,the most common anatomic location is the common bile duct,followed by the perihilar region and the cystic duct.Jaundice is the most common finding.Curative surgery was realized in the majority of cases and longterm disease-free survival was achieved when surgery was curative.CONCLUSIONS:Carcinoid tumors obstructing the biliary tree are extremely difficult to diagnose preoperatively,and nearly impossible to differentiate from non-neuroendocrine tumors.As surgery offers the only potential cure for both biliary carcinoids and cholangiocarcinoma,we recommend aggressive surgical therapy as the treatment of choice in every case of potentially resectable biliary tumor. | Evangelos Felekouras Athanasios Petrou Konstantinos Bramis Evangelos Prassas Ioannis Papaconstantinou Nikoleta Dimitriou Anastasia Pazaiti Christos Tsigris Athanasios Giannopoulos | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 5 |
| 5 | Capsule endoscopy retention as a helpful tool in the management of a young patient with suspected small-bowel disease显示文摘Capsule endoscopy is an easy and painless procedure permitting visualization of the entire small-bowel during its normal peristalsis. However, important problems exist concerning capsule retention in patients at risk of small bowel obstruction. The present report describes a young patient who had recurrent episodes of overt gastrointestinal bleeding of obscure origin, 18 years after small bowel resection in infancy for ileal atresia. Capsule endoscopy was performed, resulting in capsule retention in the distal small bowel. However, this event contributed to patient management by clearly identifying the site of obstruction and can be used to guide surgical intervention, where an anastomotic ulcer is identified. | Chryssostomos Kalantzis Periklis Apostolopoulos Panagiota Mavrogiannis Dimitrios Theodorou Xenophon Papaharalampous Ioannis Bramis Nikolaos Kalantzis | 2007 | World Journal of Gastroenterology2007，13，8： | 5 |
| 6 | Laparoscopic fenestration of multiple giant biliary mucinous cystadenomas of the liver显示文摘Biliary cystadenomas of the liver are rare, cystic neoplasms of the biliary ductal system usually occur in middle aged women. We report a case of synchronous multiple huge biliary mucinous cystadenomas with unique features. This is, according to our knowledge, the first report in the literature about three synchronously occurring hepatobiliary cystadenomas. Cystadenomas have a strong tendency to recur, particularly following incomplete excision, and a potential of malignant transformation. A therapeutic re-evaluation may be necessary when the diagnosis of hepatobiliary cystadenoma is made after the operation and an open liver resection should be considered. | A Manours E Lagoudianakis L Alevizos H Markogiannakis G Kafiri C Bramis K Filis K Toutouzas | 2008 | World Journal of Gastroenterology2008，14，26： | 2 |
| 7 | Association of the clock genes polymorphisms with colorectal cancer susceptibility显示文摘 | Theodoros Karantanos George Theodoropoulos Maria Gazouli Anna Vaiopoulou Christina Karantanou Dimitrios J. Stravopodis Konstantinos Bramis Maria Lymperi Dimitrios Pektasidis | 2013 | J Surg Oncol2013，，8： | 2 |
| 8 | Longitudinal study of motor recov- ery after stroke: reoruitment and focusing of brain activation 显示文摘 | Feydy A Carlier R Brami A | 2002 | Stroke2002，33，6： | 1 |
| 9 | Surgery via natural orifices in human beings: yesterday, today, tomorrow显示文摘 | MORIS DN BRAMIS KJ MANTONAKIS EI | 2012 | Am J Surg2012，204，1： | 1 |
| 10 | Assessment of JC Polyoma Virus in Colon Neoplasms显示文摘 | George Theodoropoulos M.D. Ph.D. Dimitris Panoussopoulos M.D. Ph.D. Ioannis Papaconstantinou M.D. Maria Gazouli Ph.D. Marina Perdiki M.D. John Bramis M.D. Ph.D. Andreas Ch. Lazaris M.D. Ph.D | 2005 | Diseases of the Colon & Rectum2005，，1： | 1 |
| 11 | Incidental para- thyroidectomy during thyroid surgery: an underappreciated complication of thyroidectomy 显示文摘 | Sakorafas GH Stafyla V Bramis C | 2005 | World J Surg2005，29，12： | 1 |
| 12 | Longitudinal study of motor recovery after stroke:recruitment and focusing of brain activation 显示文摘 | Feydy A Carlier R Brami A | 2002 | Stroke2002，33，6： | 1 |
| 13 | Incidental parathyroidectomy during thyroid surgery: an underappreciated complication of thyroidectomy显示文摘 | Sakorafas GH Stafyla V Bramis C | 2005 | WorldJ Surg2005，29，12： | 1 |
| 14 | Acute recurrent pancrea- titis: a possible clinical manifestation of ampullary cancer 显示文摘 | Petrou A Bramis K Williams T | 2011 | JOP2011，12，6： | 1 |
| 15 | Postoperative pain relief after laparoscopic cholecystectomy: A placebo-controlled double-blind randomized trial of preincisional infiltration and intraperitoneal instillation of levobupivacaine 0.25%显示文摘 | A. A. Louizos S. J. Hadzilia E. Leandros I. K. Kouroukli L. G. Georgiou J. P. Bramis | 2005 | Surgical Endoscopy2005，，11： | 1 |
| 16 | Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen- and stress- activated kinase- 1 显示文摘 | Brami - Cherrier K Lavaur J Pages C | 2007 | J Neurochem2007，101，： | 1 |
| 17 | Effects of Gas Phase Impurties on the Topochemical Kine tic Behaviour of Uranium Hydride Development显示文摘 | Brami D Kremmer A | 1988 | J Less-Comm Met1988，139，： | 1 |
| 18 | Vascular complications of pancreas transplantation显示文摘 | Bramis J Burke GW Miller J | 2004 | Pancreas2004，28，4： | 1 |
| 19 | Microsurgical renal transplantation techniques in small animals显示文摘 | Bramis T P Sloane C E Schanzer H | 1977 | Invest Urol1977，15，1： | 1 |
| 20 | Incidental parathyroideetomy during thyroid surgery : an underappreciated complication of thyroidectomy显示文摘 | Sakorafas GH Stafyla V Bramis C | 2005 | World J Surg2005，29，12： | 1 |
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