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| 1 | 胆囊癌的临床诊疗现状与挑战显示文摘胆囊癌在胃肠道癌症中位居第五位,同时它也是胆道最常见的恶性肿瘤,约占80%~95%。这种肿瘤预后不佳,总体5年生存率低于5%,平均中位生存期〈6个月。因为胆囊癌在进展时可以没有任何症状,所以早期诊断是至关重要。术前诊断为胆囊结石,而术后确诊为胆囊癌的发生率为0.5%~1.5%。如果术前怀疑患者胆囊癌,则不应通过腹腔镜手术。流行病学研究已经确定了胆囊癌的发病率有地理和种族的显著差异:美洲的印第安人高发,东南亚地区也比较高,但在美洲和世界的其他地区发病率较低。环境诱发因素在胆囊癌的发展过程中发挥关键作用,胆石症、胆道和寄生虫感染的慢性炎症是最好的例证。在过去的10年里,改进成像技术和改良根治的手术方法可改善患者的预后,并帮助延长胆囊癌患者的存活时间。对于R0切除的胆囊癌患者,其总体5年生存率为21%~69%。在将来,潜在的诊断标志物的发展将对那些种族易感性或已知胆道解剖异常的人群提供早期筛查诊断的机会。 | Mislav Raki? Leonardo Patrlj Mario Kopljar Robert Kli?ek Marijan Kolovrat Bozo Loncar Zeljko Busic 冯铁诚 | 2016 | 中国普通外科杂志2016，25，2： | 24 |
| 2 | Multiple metastases to the small bowel from large cell bronchial carcinomas显示文摘AIM: Metastases from lung cancer to gastrointestinal tract are not rare atpostmortem studies but the development of clinically significant symptoms from the gastrointestinal metastases is very unusual.METHODS: Formalin-fixed, paraffin-embedded tissues were cut into 5 μm thick sections and routinely stained with hematoxylin and eosin. Some slides were also stained with Alcian-PAS. Antibodies used were primary antibodies to pancytokeratin, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, vimentin, smooth muscle actin and CD-117.RESULTS: We observed three patients who presented with multiple metastases from large cell bronchial carcinoma to small intestine. Two of them had abdominal symptoms (sudden onset of abdominal pain, constipation and vomiting) and in one case the tumor was incidentally found during autopsy. Microscopically, all tumors showed a same histological pattern and consisted almost exclusively of strands and sheets of poorly cohesive, polymorphic giant cells with scanty, delicate stromas. Few smaller polygonal anaplastic cells dispersed between polymorphic giant cells,were also observed. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin and vimentin. Microscopically and immunohistochemically all metastases had a similar pattern to primary anaplastic carcinoma of the small intestine.CONCLUSION: In patients with small intestine tumors showing anaplastic features, especially with multiple tumors, metastases from large cell bronchial carcinoma should be first excluded, because it seems that they are more common than expected. | Davor Tomas Mario Ledinsky Mladen Belicza Bozo Kru(s|ˇ)lin | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 3 | An unusual mixed germ cell tumor of the testis consisting of rhabdomyosarcoma, mature teratoma and yolk sac tumor显示文摘 | Eva Lovric Dubravka Bobonj Hizak Melita Peric Balja Tanja Lenicek Bozo Kruslin | 2010 | Asian Journal of Andrology2010，12，3： | 2 |
| 4 | Mercury distribution and speciation in Lake Balaton, Hungary显示文摘 | H.L. Nguyen M. Leermakers S. Kurunczi L. Bozo W. Baeyens | 2005 | Science of the Total Environment2005，，1： | 2 |
| 5 | Oxamides as novel NR2B selective NMDA receptor antagonists显示文摘 | BARTA-SZALAI G BORZA I BOZO E | 2004 | Bioorg Med Chem Lett2004，14，15： | 1 |
| 6 | Conservative treatment of female stress urinary incontinence with functional electrical stimulation 显示文摘 | Bozo Kralj | 1999 | European J Obstet Gynecol1999，85，： | 1 |
| 7 | Characteriation of ceria-zirconia solid solutions after hydrothermal ageing 显示文摘 | Francois Gaillard Nolven Guihaume | 2001 | Applied Catalysis A:General2001，220，： | 1 |
| 8 | Selective NRI/2B N- methyl-D-aspartate receptor antagonists among Indole-2- earboxamides and benzimidazole-2-carboxamides 显示文摘 | Borzal Bozo E Barta-Szalai G | 2007 | Journal of Medicinal Chem/st2007，50，5： | 1 |
| 9 | Optimization of dispatching crite- ria for open-pit truck haulage system design using multiple compari- sons with the best and common random numbers 显示文摘 | Mutmansky Jan M Kolonja Bozo | 1993 | Winter Simula- tion Conference Proceedings1993，，3： | 1 |
| 10 | Combustion ofmethane on CeO2-ZrO2 based catalysts 显示文摘 | Bozo C Guilhaume N Garbowski E | 2000 | Catalysis Today2000，59，12： | 1 |
| 11 | Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain 显示文摘 | Fabian G Bozo B Szikszay M | 2002 | J Pharmacol Exp Ther2002，302，2： | 1 |
| 12 | Design and implementation of the extended Kalman filter for the speed and rotor position estimation of brushless DC motor显示文摘 | Bozo Terzie Martin Jadrie | 2001 | IEEE Transactions on Industrial Electronics2001，48，6： | 1 |
| 13 | Application of a surrogatemodeling to the ship structural design 显示文摘 | PERO P VEDRAN Z BOZO VAZIC | 2014 | Ocean engineering2014，84，： | 1 |
| 14 | Combustion of methane on CeO2-ZrO2 based catalysts显示文摘 | BOZO C GUILHAUME N GARBOWSKI E PRIMET M | 2000 | Catal Today2000，59，12： | 1 |
| 15 | Different mycotoxin inactivation applications, and their inactivation mechanisms 显示文摘 | Bozo glu Faruk | 2009 | Zbornik Matice Srpske za Prirodne Nauke2009，117，： | 1 |
| 16 | Design and implementation of the extended Kalman filter for the speed and rotor position estimation of brushless DC motor显示文摘 | Bozo T Martin J | 2001 | IEEE Trans on Indust Electron2001，48，6： | 1 |
| 17 | Combustion of methane on CeO2-ZrO2 based catalysts 显示文摘 | Bozo C Guilhaume N Garbowski E | 2000 | Catalysis Today2000，59，： | 1 |
| 18 | Does transurethral thermotherapy induce long-term alpha blockade? An immunohistochemical study显示文摘 | Perachino M Bozo W Puppo P | 1993 | Eur urol1993，23，2： | 1 |
| 19 | An analysis of eombined cyclic heat treatment perfomlanee 显示文摘 | Bozo Smoljan | 2004 | Materials Processing Technology2004，15，5156： | 1 |
| 20 | Simultaneous determination of diclofenac,its human metabolites and microbial nitration/nitrosation transformation products in wastewaters by liquid chromatography/quadrupole-linear ion trap mass spectrometry显示文摘 | Victoria O Marta IB Bozo Z | 2014 | J Chromatogr A2014，1347，： | 1 |
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