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| 1 | Utility of tissue microarrays for profiling prognostic biomarkers in clinically localized prostate cancer: the expression of BCL-2, E-cadherin, Ki-67 and p53 as predictors of biochemical failure after radical prostatectomy with nested control for clinical and pathological risk factors显示文摘痊愈不能与经历激进的治疗的临床上局部性的前列腺癌症为所有人被保证。如果他们能改进秘密变形疾病的预言,分子的标记将是无价的。这研究被执行在激进的前列腺切除术标本调查 BCL-2, Ki-67, p53 和 E-cadherin 的表示。我们寻求了估计他们的能力在一个特定的治疗学的背景预言早生物化学的恶化。包括 41 案例对的 82 个病人为病理学的舞台,格利森等级和外科手术前的前列腺特定的抗原(PSA ) 被匹配集中。在每对的一个病人有生物化学的复发(在 2 年外科以内定义为 PSA 0.2 ng mL-1 ) 并且其它没有疾病生物化学地留下了(至少 3 年在外科以后定义同样无法发现的 PSA ) 。Immunohistochemical 分析被执行在四上估计标记表示复制从每个激进的前列腺切除术标本与良性、恶意的织物构造的织物 microarrays。Ki-67, p53 和 BCL-2,然而并非 E-cadherin,显著地在前列腺腺癌的 upregulated 与良性的前列腺织物相比(P < 0.01 ) 。然而,当比较与没有生物化学的复发的病人一起开发了早生物化学的恶化的病人时,在任何标记的表示的重要差别都没被观察。这研究证明 p53, BCL-2 和 Ki-67 的那表情与良性的前列腺织物相比是在临床上局部性的前列腺癌症的 upregulated,没有在 E-cadherin 表示的改变。Biomarker upregulation 没在激进的前列腺切除术以后为生物化学的复发有预示的价值,甚至在考虑病理学的舞台,整个瘤格利森等级和外科手术前的浆液 PSA 水平以后。 | Joseph Nariculam Alex Freeman Simon Bott Phillipa Munson Noriko Cable Nicola Brookman-Amissah Magali Williamson Roger S. Kirby John Masters Mark Feneley | 2009 | Asian Journal of Andrology2009，11，1： | 5 |
| 2 | Assessment of left-ventricular diastolic function in pediatric intensive-care patients:a review of parameters and indications compared with those for adults显示文摘Background The incidence of diastolic heart failure has increased over time.The evaluation of left-ventricular diastolic func-tion is complex,ongoing,and remains poorly performed in pediatric intensive-care patients.This study aimed to review the literature and to provide an update on the evaluation of left-ventricular diastolic function in adults and children in intensive care.Data sources We searched data from PubMed/Medline.Thirty-two studies were included.Four pragmatic questions were identified:(1)What is the physiopathology of diastolic dysfunction?(2)Which tools are required to evaluate diastolic func-tion?(3)What are the echocardiographic criteria needed to evaluate diastolic function?(4)When should diastolic function be evaluated in pediatric intensive care?Results Early diastole allows characterization of relaxation,whereas compliance assessments and filling pressures are evalu-ated during late diastole.The evolution of diastolic function differs between adults and children.Unlike in adults,decreased compliance occurs at the same time as delayed relaxation in children.Diastolic function can be evaluated by Doppler echo-cardiography.The echocardiographic criteria for ventricular relaxation include the E wave,E/A wave ratio,and isovolumic relaxation time.Ventricular compliance can be assessed by the E/e'wave ratio,atrial volume,and Ap wave duration during pulmonary vein flow.In adult intensive-care patients,the E/e'ratio can be used as an index of tolerance for volume expan-sion in septic patients and to adjust the inotropic support.Conclusion Clinical studies would allow some of these parameters to be validated for use in children in intensive care. | Morgan Recher Astrid Botte Jerome Soquet Jean-Benoit Baudelet François Godart Stephane Leteurtre | 2021 | World Journal of Pediatrics2021，17，1： | 2 |
| 3 | The influence of the MAPK pathway on T cell lineage commitment显示文摘 | SHARP L L SCHWARZ D A BOTT C M | 1997 | Immunity1997，7，5： | 1 |
| 4 | Understanding the kinetics of coal electrolysis at intermediate temperatures显示文摘 | JIN X BOTTE G G | | 0，，15： | 1 |
| 5 | Modeling lithium intercalation in a porous carbon electrode显示文摘 | BOTTE G~ WHITE R E | 2001 | Journal of the Electrochemical Society2001，148，1： | 1 |
| 6 | Phos- phorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding显示文摘 | THAXTON C LOPERA J BOTT M | 2007 | Mol Cell Neurosci2007，34，： | 1 |
| 7 | Complication of the smooth pin fixation of fracture and dislocation in the handand wrist显示文摘 | Botte M J Davis JL Rosa BA | 1992 | Clin Orthop1992，，276： | 1 |
| 8 | Complications in the use of the halo fixation device显示文摘 | Garfin SR Botte MJ Waters RL | 1986 | J Bone Joint Surg Am1986，68，3： | 1 |
| 9 | Biofouling in Water Systems 显示文摘 | Melo L F Bott T R | 1997 | Experimental Thermal and Fluid Science1997，14，4： | 1 |
| 10 | Use of normal-curve theory in crop insurance rate making显示文摘 | Botts RR Boles JN | 1958 | Journal of Farm Economics1958，40，： | 1 |
| 11 | Isolation and characterization of Cryptococcus neoformans spores reveal a critical role for capsule biosynthesis genes in spore biogenesis显示文摘 | Botts MR Giles SS Gates MA | 2009 | Eukaryot Cell2009，8，4： | 1 |
| 12 | Thermal stability of LiPF6-EC-EMC electrolyte for lithium ion batteries显示文摘 | BOTTE G G WHITE R E ZHANG Z M | 2001 | J Power Sources2001，9798，： | 1 |
| 13 | Anatomy of the juncturae tendium of the hand显示文摘 | Von Schroeder HP Botte MJ Gellman H | 1990 | J Hand Surg(Am)1990，15，： | 1 |
| 14 | Potamiden aus Sud-Asien (Crustacea, Decapoda) 显示文摘 | Bott R | 1968 | Senckenbergiana Biol1968，49，2： | 1 |
| 15 | Laboratory modelling of manganese biofiltration using biofilms of Leptothrix discophora显示文摘 | HOPE C K BOTT T R | | 0，，07： | 1 |
| 16 | SureCure--A new material to reduces curing time and improve curing reproducibility of lead- acid batteries显示文摘 | Boden D P Loosemore D V Botts G D | 2006 | Journal of Power Sources2006，158，2： | 1 |
| 17 | Techniques for reducing the amount of biocide necessary to counteract the effects of biofilm growth in cooling water systems 显示文摘 | Bott T R | 1998 | Appl Therm Eng1998，18，： | 1 |
| 18 | Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells:Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression显示文摘 | Grillo M Bott M J Khandke N | 2005 | Breast Cancer Res Treat2005，1，12： | 1 |
| 19 | Managers' lead- ership and critical care nurses' intent to stay显示文摘 | BOYLE D K BOTT M J HANSEN H E | 1999 | Am J Crit Care1999，8，6： | 1 |
| 20 | Treatment of malunion of the distal radius显示文摘 | Amadio PC Botte MJ | 1987 | Hand Clin1987，3，4： | 1 |
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