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| 1 | Meta-Analysis of Randomized Controlled Trials Comparing Intracoronary and Intravenous Administration of Glycoprotein IIb/IIIa Inhibitors in Patients With ST-Elevation Myocardial Infarction显示文摘 | Yongshi Wang Boting Wu Xianhong Shu | 2012 | The American Journal of Cardiology2012，，8： | 2 |
| 2 | MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages显示文摘Primary immune thrombocytopenia(ITP)is an autoimmune hemorrhagic disorder in which macrophages play a critical role.Mammalian sterile-20-like kinase 4(MST4),a member of the germinal-center kinase STE20 family,has been demonstrated to be a regulator of inflammation.Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive.The expression and function of MST4 in macrophages of ITP patients and THP-1 cells,and of a macrophage-specific Mst4−/−(Mst4ΔM/ΔM)ITP mouse model were determined.Macrophage phagocytic assays,RNA sequencing(RNA-seq)analysis,immunofluorescence analysis,coimmunoprecipitation(co-IP),mass spectrometry(MS),bioinformatics analysis,and phosphoproteomics analysis were performed to reveal the underlying mechanisms.The expression levels of the MST4 gene were elevated in the expanded M1-like macrophages of ITP patients,and this elevated expression of MST4 was restored to basal levels in patients with remission after high-dose dexamethasone treatment.The expression of the MST4 gene was significantly elevated in THP-1-derived M1 macrophages.Silencing of MST4 decreased the expression of M1 macrophage markers and cytokines,and impaired phagocytosis,which could be increased by overexpression of MST4.In a passive ITP mouse model,macrophage-specific depletion of Mst4 reduced the numbers of M1 macrophages in the spleen and peritoneal lavage fluid,attenuated the expression of M1 cytokines,and promoted the predominance of FcγRIIb in splenic macrophages,which resulted in amelioration of thrombocytopenia.Downregulation of MST4 directly inhibited STAT1 phosphorylation,which is essential for M1 polarization of macrophages.Our study elucidates a critical role for MST4 kinase in the pathology of ITP and identifies MST4 kinase as a potential therapeutic target for refractory ITP. | Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 3 | Author Correction:MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages显示文摘In this article,the details for Affiliation 1 were incorrectly given as‘Department of Hematology,Fudan University,Shanghai 200032,China’but should have been‘Department of Hematology,Zhongshan Hospital,Fudan University,Shanghai 200032,China’;the details for Affiliation 3 were incorrectly given as‘Department of Transfusion Medicine,Fudan University,Shanghai 200032,China’but should have been‘Department of Transfusion Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China’;the details for Affiliation 4 were incorrectly given as‘Department of Laboratory Medicine,Fudan University,Shanghai 200032,China’but should have been‘Department of Laboratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China’.The original article has been corrected. | Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 4 | Direct mask-free fabrication of patterned hierarchical graphene electrode for on-chip micro-supercapacitors显示文摘Graphene-based electrodes with rational structural design have shown extraordinary prospect for en-hanced electrical double-layer capacitance of micro-supercapacitors(MSCs).Herein,a facile fabrication method for flexible planar MSCs based on hierarchical graphene was demonstrated by using a laser-treated membrane for electrode patterning,complemented with hierarchical electrode configuration tak-ing full advantages of size-determined functional graphene.The in-plane interdigital shape of MSCs was defined through vacuum filtration with the assistance of the functionalized polypropylene(PP)mem-brane.The hierarchical graphene films were built by macroscopic assembly based on size effect of differ-ent lateral sized graphene sheets(rGO-LSL).The sample of MSCs based on rGO-L SL(MSCs-LSL)exhibited excellent volumetric capacitance of 6.7 F cm^(−3) and high energy density of 0.37 mWh cm−3.The MSCs-LSL presented superb flexibility and cycling stability with no capacitance deteroriated after 2000 cycles.This newly developed fabrication strategy is of good scalability and designability to manufacture flexible elec-trode for MSCs with customized shapes,while the construction of hierarchical graphene can enlighten the structural design of analogous two-dimensional materials for potential advanced electronics. | Yaopeng Wu Jinghong Chen Wei Yuan Xiaoqing Zhang Shigen Bai Yu Chen Bote Zhao Xuyang Wu Chun Wang Honglin Huang Yong Tang Zhenping Wan Shiwei Zhang Yingxi Xie | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 5 | Synthesis of Large-Pore ECNU-19 Material (12 × 8-R) via Interlayer- Expansion of HUS-2 Lamellar Silicate显示文摘 | Boting Yang Jin-Gang Jiang Hao Xu Haihong Wu Peng Wu | 2018 | Chinese Journal of Chemistry2018，36，3： | 0 |
| 6 | 3D amorphous carbon and graphene co-modified LiFePO_4 composite derived from polyol process as electrode for high power lithium-ion batteries显示文摘Amorphous carbon and graphene co-modified LiFePO_4 nanocomposite has been synthesized via a facile polyol process in connection with a following thermal treatment.Various characterization techniques,including XRD.Mossbauer spectra,Raman spectra,SEM,TEM,BET,O_2-TPO,galvano charge-discharge,CV and EIS were applied to investigate the phase composition,carbon content,morphological structure and electrochemical performance of the synthesized samples.The effect of introducing way of carbon sources on the properties and performance of LiFePO_4/C/graphene composite was paid special attention.Under optimized synthetic conditions,highly crystalized olivine-type LiFePO_4was successfully obtained with electron conductive Fe_2P and FeP as the main impurity phases.SEM and TEM analyses demonstrated the graphene sheets were randomly distributed inside the sample to create an open structured LiFePO_4 with respect to graphene,while the glucosederived carbon mainly coated over LiFeP04 particles which effectively connected the graphene sheets and LiFePO_4 particles to result in a more efficient charge transfer process.As a result,favorable electrochemical performance was achieved.The performance of the amorphous carbon-graphene co-modified LiFePO_4 was further progressively improved upon cycling in the first 200 cycles to reach a reversible specificcapacity as high as 97 mAh·g^(-1) at 10 C rate. | Guan Wu Ran Ran Bote Zhao Yujing Sha Chao Su Yingke Zhou Zongping Shao | 2014 | Journal of Energy Chemistry2014，23，3： | 0 |
| 7 | Preparation of Co- or Mn-substituted LTL zeolites and their catalytic properties in cyclohexane oxidation显示文摘Co-or Mn-substituted LTL zeolites were hydrothermally synthesized by a novel organic-ligand-assisted method.XRD,UVVis DRS,XPS,and EPR techniques verified that the Co and Mn ions were incorporated into the zeolite framework.No organic species were retained in as-synthesized Co or Mn-LTL zeolites,which resulted in porous materials without calcination.In the oxidation of cyclohexane with tert-butyl hydroperoxide(TBHP),the Co-LTL and Mn-LTL gave a 40%–48%KA oil(cyclohexanone and cyclohexanol)yield as well as nearly 100%TBHP conversion under mild reaction conditions.The reactions were confirmed to be heterogeneous and to have proceeded catalytically.No loss of catalytic activity or leaching of metal active sites ions were observed during 4 reuses. | Kai Xue Boting Yang Peng Wu | 2015 | Science China Chemistry2015，58，1： | 0 |
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