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| 1 | Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection显示文摘AIM: Previous studies suggest that loss of bone mineral density (BMD) frequently occurs in patients with chronic viral liver disease, presenting with histologically proven liver cirrhosis. However, little is known about the occurrence of bone disease in non-cirrhotic patients with chronic hepatitis B or C. Therefore, it was the aim of this study to evaluate this particular population for BMD and bone turnover markers.METHODS: Biochemical markers of bone turnover and BMD were measured in 43 consecutive patients with HCV (n = 30)or HBV (n = 13) infection without histological evidence for liver cirrhosis. Mean age was 49 years (range 26-77 years). BMD was measured by dual X-ray absorptiometry in the femoral neck (FN) and the lumbar spine (LS) region. In addition, bone metabolism markers were measured.RESULTS: BMD was lowered in 25 (58%) of the patients with chronic hepatitis B or C (FN: 0.76 (0.53-0.99); LS:0.96 (0.62-1.23) g/cm2). Eight (32%) osteopenic patients were diagnosed with osteoporosis. Bone-specific alkaline phosphatase (P = 0.005) and intact parathyroid hormone (iPTH) (P = 0.001) were significantly elevated in the more advanced stages of fibrosis. Mean 7-score value was lower in patients with chronic hepatitis C as compared to patients suffering from chronic hepatitis B; however, the difference was not statistically significant (P = 0.09).CONCLUSION: There was a significantly reduced BMD in non-cirrhotic patients with chronic hepatitis B or C infection. Alterations of bone metabolism already occurred in advanced liver fibrosis without cirrhosis. According to our results, these secondary effects of chronic viral hepatitis should be further investigated. | Ingolf Schiefke Andreas Fach Marcus Wiedmann Andreas V.Aretin Eva Schenker Gudrun Borte Manfred Wiese Joachim Moessner | 2005 | World Journal of Gastroenterology2005，11，12： | 23 |
| 2 | Contribution of the ear and the flag leaf to grainfilling in durum wheat inferred from the carbon isotope signature: Genotypic and growing conditions effects显示文摘The ear, together with the flag leaf, is believed to play a major role as a source of assimilates during grain filling in C3cereals. However, the intrusive nature of most of the available methodologies prevents reaching conclusive results in this regard. This study compares the carbon isotope composition(d13C) in its natural abundance in the water‐soluble fractions of the flag leaf blade and the ear with the d13C of mature kernels to assess the relative contribution of both organs to grain filling in durum wheat(Triticum turgidum L. var.durum). The relative contribution of the ear was higher in landraces compared to modern cultivars, as well as in response to nitrogen fertilization and water stress. Such genotypic and environmentally driven differences were associated with changes in harvest index(HI), with the relative contribution of the ear being negatively associated with HI. In the case of the genotypic differences, the lower relative contribution of the ear in modern cultivars compared with landraces is probably associated with the appearance in the former of a certain amount of source limitation driven by a higher HI. In fact, the relative contribution of the ear was far more responsive to changes in HI in modern cultivars compared with landraces. | Rut Sanchez-Bragado Abdelhalim Elazab Bangwei Zhou Maria Dolors Serret Jordi Bort Maria Teresa Nieto-Taladriz José Luis Araus | 2014 | Journal of Integrative Plant Biology2014，56，5： | 10 |
| 3 | Wheat ear carbon assimilation and nitrogen remobilization contribute significantly to grain yield显示文摘The role of wheat ears as a source of nitrogen(N)and carbon(C) in the grain filling process has barely been studied. To resolve this question, five wheat genotypes were labeled with15N-enriched nutrient solution. N remobilization and absorption were estimated via the nitrogen isotope composition of total organic matter and Rubisco. Gas exchange analyses showed that ear photosynthesis contributed substantially to grain filling in spite of the great loss of C due to respiration. Of the total kernel N, 64.7% was derived from the N acquired between sowing and anthesis, while the remaining35.3% was derived from the N acquired between anthesis and maturity. In addition, 1.87 times more N was remobilized to the developing kernel from the ear than from the flag leaf. The higher yielding genotypes showed an increased N remobilization to the kernel compared to the lower yielding genotypes. Inaddition, the higher yielding genotypes remobilized more N from the ears to the kernel than the lower yielding genotypes,while the lower yielding genotypes remobilized more N from the flag leaf to the kernel. Therefore, the ears contribute significantly toward fulfilling C and N demands during grain filling. | Bangwei Zhou Maria Dolores Serret Abdelhalim Elazab Jordi Bort Pie José Luis Araus Iker Aranjuelo álvaro Sanz-Sáez | 2016 | Journal of Integrative Plant Biology2016，58，11： | 9 |
| 4 | Physiological traits contributed to the recent increase in yield potential of winter wheat from Henan Province, China显示文摘This experiment aims to test the traits responsible for the increase in yield potential of winter wheat released in Henan Province, China. Seven established cultivars released in the last 20 years and three advanced lines were assayed. The results showed that grain yield was positively correlated with harvest index(HI), kernel number per square meter, and aboveground biomass. In addition, the HI and aboveground biomass showed an increasing trend with the year of release.Therefore, we can conclude that bread wheat breeding advances during recent decades in Henan Province, China,have been achieved through an increase in HI, kernel number per square meter, and aboveground biomass. A higher d13C seems also to be involved in these advances, which suggests a progressive improvement in constitutive water use efficiency not associated with a trend towards lower stomatal conductance in the most recent genotypes. However, genetic advance Researchdoes not appear related to changes in photosynthesis rates on area basis when measured in the flag leaf or the spike,but only to a higher, whole‐spike photosynthesis. Results also indirectly support the concept that under potential yield conditions, the spike contributed more than the flag leaf to kernel formation. | Bangwei Zhou álvaro Sanz-Sáez Abdelhalim Elazab Tianmin Shen Rut Sánchez-Bragado Jordi Bort Maria Dolors Serret José Luis Araus | 2014 | Journal of Integrative Plant Biology2014，56，5： | 6 |
| 5 | Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer- binding protein alpha and hepatoeyte nuclear factor-3 gamma显示文摘 | RODRIGUEZ-ANTONA C BORT R JOVE R | 2003 | Mol Pharmacol2003，63，5： | 1 |
| 6 | Formation of the joint dissimilar metals in the solid phase by the method of vacuum hot rolling 显示文摘 | BORTS B V | 2012 | Materials Science2012，47，5： | 1 |
| 7 | Server virtualization: controlling server spiraling costs显示文摘 | BORT J | 2003 | IEEE Communications Magazine2003，41，2： | 1 |
| 8 | Hex homeobox gene controls the transition of the endoderm to a pseudostratified,cell emergent epithelium for liver bud development显示文摘 | BORT R SIGNORE M TREMBLAY K | 2006 | Dev Biol2006，290，： | 1 |
| 9 | Increased toxicity of cocaine on human hepatocytes induced by ethanol:role of GSH显示文摘 | Ponsoda X Bort R Jover R | 1999 | Biochemical Pharmacology1999，58，10： | 1 |
| 10 | Hex homeobox gene -dependent tissue positioning is required for organogenesis of the ventral pancreas显示文摘 | BORT R MARTINEZ-BARBERA J P BEDDINGTON R S | 2004 | Development2004，131，： | 1 |
| 11 | Role of hep- atocyte nuclear factor 3 gamma in the expression of hu- man CYP2C genes 显示文摘 | Bort R Gomez-Leehnn MJ Castell JV | 2004 | Arch Biochem Biophys2004，426，1： | 1 |
| 12 | Assessment of Shock Design Methods and Shock Specifications显示文摘 | Bort R L | 1962 | SNAME Trans1962，70，4： | 1 |
| 13 | Refixation of respiratory CO2 in the ears of C3 cereals显示文摘 | Bort J Brown R H Araus J L | 1996 | J Exp Bot1996，47，： | 1 |
| 14 | The combined effect of constant water deficit and nitrogen supply on WUE, NUE and AI3C in durum wheat potted plants显示文摘 | Cabrera-Bosquet L Molero G Bort J 1Nogues S Araus J L | 2007 | Ann Appl Biol2007，151，： | 1 |
| 15 | Transumbilical single- access laparoscopic left adrenalectomy for giant malignant pheocromocytoma显示文摘 | Dapri G Zulian V Bortes M | 2015 | Surgical oncology2015，24，1： | 1 |
| 16 | Hepatic metabolism of diclofenac:role of human CYP in the minor oxidative pathways显示文摘 | Bort R Mace K BoobisA | 1999 | Biochem Pharmacol1999，58，5： | 1 |
| 17 | The effect of breasffeeding on weight gain in infants: results of a birth cohort study 显示文摘 | Heinrich J Borte N Schaaf B | 2005 | Eur J Med Res2005，10，1： | 1 |
| 18 | Assessment of shock design methods and shock specifications显示文摘 | Bort R L | 1962 | Transaction SNAME1962，70，4： | 1 |
| 19 | Percutaneous transgastric irrigation drainage in combination with endoscopic necrosectomy in necrotizing pancreatitis (with videos) <ce:link locator='fx1'/>显示文摘 | Susanne Raczynski Niels Teich Gudrun Borte Henning Wittenburg Joachim M?ssner Karel Caca | 2006 | Gastrointestinal Endoscopy2006，，3： | 1 |
| 20 | Relationship between leaf structure and carbon isotope discrimination in field grown barley显示文摘 | ARAUS J L BORT J CECCARELLI L GRANDO S | 1997 | Plant Physiology and Biochemistry1997，35，： | 1 |
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