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| 1 | L-carnitine protects C2C12 cells against mitochondrial superoxide overproduction and cell death显示文摘AIM To identify and characterize the protective effect that L-carnitine exerted against an oxidative stress in C2C12 cells.METHODS Myoblastic C2C12 cells were treated with menadione, a vitamin K analog that engenders oxidative stress, and the protective effect of L-carnitine(a nutrient involved in fatty acid metabolism and the control of the oxidative process), was assessed by monitoring various parameters related to the oxidative stress, autophagy and cell death. RESULTS Associated with its physiological function, a muscle cell metabolism is highly dependent on oxygen and may produce reactive oxygen species(ROS), especially under pathological conditions. High levels of ROS are known to induce injuries in cell structure as they interact at many levels in cell function. In C2C12 cells, a treatment with menadione induced a loss of transmembrane mitochondrial potential, an increase in mitochondrial production of ROS; it also induces autophagy and was able to provoke cell death. Pre-treatment of the cells with L-carnitine reduced ROS production, diminished autophagy and protected C2C12 cells against menadione-induced deleterious effects. CONCLUSION In conclusion, L-carnitine limits the oxidative stress in these cells and prevents cell death. | Francoise Le Borgne Gaetan Ravaut Arnaud Bernard Jean Demarquoy | 2017 | World Journal of Biological Chemistry2017，8，1： | 3 |
| 2 | Crosstalk between mitochondria and peroxisomes显示文摘Mitochondria and peroxisomes are small ubiquitous organelles. They both play major roles in cell metabolism,especially in terms of fatty acid metabolism,reactive oxygen species(ROS) production,and ROS scavenging,and it is now clear that they metabolically interact with each other. These two organelles share some properties,such as great plasticity and high potency to adapt their form and number according to cell requirements. Their functions are connected,and any alteration in the function of mitochondria may induce changes inperoxisomal physiology. The objective of this paper was to highlight the interconnection and the crosstalk existing between mitochondria and peroxisomes. Special emphasis was placed on the best known connections between these organelles:origin,structure,and metabolic interconnections. | Jean Demarquoy Francoise Le Borgne | 2015 | World Journal of Biological Chemistry2015，6，4： | 2 |
| 3 | Quantification of the effects of nitrates, phosphates and chlorides on soil stabilization with lime and cement显示文摘 | Olivier Cuisinier Tangi Le Borgne Dimitri Deneele Farimah Masrouri | 2010 | Engineering Geology2010，，3： | 2 |
| 4 | Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment显示文摘 | Borgne A Versteege I Mahe M | 2006 | Oncogene2006，25，5： | 1 |
| 5 | A comparative study on catalyst deactivation of nickel and cobalt incorporated MCM-41 catalysts modified by platinum in methane reforming with carbon dioxide 显示文摘 | LIU D P CHEO W N E LIM Y W Y BORGN A LAU R YANG Y H | 2010 | Catalysis Today2010，154，34： | 1 |
| 6 | The roles of receptor and ligand endocytosis in regulating Notch signaling显示文摘 | Le Borgne R Bardin A Schweisguth F | 2005 | Development2005，132，： | 1 |
| 7 | Carbon dioxide reforming of methane to synthesis gas over Ni-MCM-41 catalysts 显示文摘 | LIU D P LAU R BORGN A YANG Y H | 2009 | Applied Catalysis A: General2009，358，2： | 1 |
| 8 | Biochemical and cellular effects of roscovitine,a potent and selective inhibitor of the eyelin-dependent kinases cdc2 ,cdk2 and cdk5 显示文摘 | Meijer L Borgne A Mulner O | 1997 | Eur J Biochem1997，243，12： | 1 |
| 9 | learning midlevel image features for natural scene and texture classification显示文摘 | Herv Le Borgne Anne Gurin Dugu Noel E O'Connor | 2007 | IEEE Transactions on Circuits and Systems for Video Technology2007，17，3： | 1 |
| 10 | Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo显示文摘 | Le Borgne M Etchart N Goubier A | | 0，，： | 1 |
| 11 | Quality of life in long- term cergieal cancer survivors: a population - based study 显示文摘 | Le Borgne G Mercier M Woronoff AS | 2013 | Gynecologic Oncology2013，129，1： | 1 |
| 12 | Assessment ofpreferential flow path connectivity and hydraulic properties atsingle-borehole and cross-borehole scales in a fractured aquifer显示文摘 | LE BORGNE T BOUR O PAILLET F L | 2006 | Journal of Hydrology2006，328，34： | 1 |
| 13 | Comparison ofalternative methodologies for identifying and characterizingpreferential flow paths in heterogeneous aquifers显示文摘 | LE BORGNE T BOUR O RILEY M S | 2007 | Journal ofHydrology2007，345，13： | 1 |
| 14 | Efficient microwave-assisted synthesis of 1-(1 H -indol-1-yl)-2-phenyl-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols as antifungal agents显示文摘 | Nicolas Lebouvier Francis Giraud Typhanie Corbin Young Min Na Guillaume Le Baut Pascal Marchand Marc Le Borgne | 2006 | Tetrahedron Letters2006，，36： | 1 |
| 15 | Quality of life in long - tem cervical cancer survivors: a population - based study显示文摘 | LE BORGNE G MERCIER M WORONOFF A S | 2013 | Gynecol Onco12013，129，： | 1 |
| 16 | A New Class of Adaptive Cross-Polarization Jamming Cancellers for Digital Radio Systems显示文摘 | Borgne M | 1987 | IEEE Journal on Selected Areas in Communication1987，5，3： | 1 |
| 17 | Programming real-time applications with signal 显示文摘 | GUERNIC P L GAUTIER T BORGNE M L | 1991 | Proceedings of the IEEE1991，79，9： | 1 |
| 18 | Biotechnological processes for the refining of petroleum显示文摘 | Le Borgne S Quintero R | 2003 | Fuel Processing Technology2003，81，2： | 1 |
| 19 | Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo显示文摘 | Le Borgne M Etchart N Goubier A | 2006 | Immunity2006，24，2： | 1 |
| 20 | Quantification of the effects of nitrates, phosphates and chlorides on soil stabilization with lime and cement显示文摘 | Olivier Cuisinier Tangi Le Borgne Dimitri Deneele | 2011 | Eng Geol2011，117，： | 1 |
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