| 6 | Synthesis of 1,2-Diphenyliminoethanols and the Evaluation of Their Possible Biological Activity显示文摘The chemical cellular signaling pathway of phosphatidylinositol-3-kinase(PI3K)is crucial in many aspects of cell growth and survival.Genetic alterations such as amplification,mutation and chromosomal transposition can compromise the PI3K pathway,leading to its permanent activation,which results in the alteration of growth control and cell survival mechanisms,favoring competitive growth,metastatic capacity,and often a greater resistance to treatments.Evidence of these destructive genetic modifications has been found in different types of cancer.Recently,a group of researchers found that the structure of benzoin matches the fingerprint of the active PI3K inhibitor.The focus of this work is on the synthesis of substituted benzoins via benzoin condensation in aqueous medium for subsequent reaction with anilines.The aim is to obtain a series of new compounds derived from 1,2-diphenyliminoethanol,which will be sent to a specialized laboratory to evaluate their cytotoxicity on carcinoma cell lines. | Portillo Borgues Jorge Eduardo Santos Santos Elvira Lejarazo Gómez Eva Florencia | 2020 | Journal of Chemistry and Chemical Engineering2020，14，1： | 0 |
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