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| 1 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 2 | Protein malnutrition : some aspects of the in vitro adhesion of peritoneal mouse macrophages显示文摘 | Borelli P Souza IP Borojevic R | 1998 | Ann Nutr Metab1998，42，6： | 1 |
| 3 | EEG-fMRI as an useful tool to detect epileptic foci associated with secondary bilateral synchrony显示文摘 | Borelli P Avesani M Formaggio E | 2010 | Seizure2010，19，9： | 1 |
| 4 | Tinea versicolor: epidemiologic,clinical and therapeutic aspects显示文摘 | Borelli D Jacobs P H Nail L | 1991 | J Am Acad Dermatol1991，25，21： | 1 |
| 5 | Immediate loading im-plant:A clinical report of 1301 implanta显示文摘 | Hruska A Borelli P Marzaduri E | | 0，，02： | 1 |
| 6 | Crotalus durissus terrificus snake venom regulates macrophage metabolism and function显示文摘 | Sampaio SC Sousa-e-Silva MC Borelli P | 2001 | J Leukoe Biol2001，70，4： | 1 |
| 7 | Cerebrospinal fluid in the diagnosis of spinal schistosomiasisI显示文摘 | Tesser E Reis Mde L Borelli P | 2005 | Arq Neuropsiquiatr2005，63，3： | 1 |
| 8 | Natural rubberlatex LbL films: Characterization and growth of fibroblasts显示文摘 | Davi C P Galdino L F M D Borelli P | 2012 | Journal of Applied Polymer Science2012，125，3： | 1 |
| 9 | Field trials of oral calcium propionate paste as an aid to prevent milk fever in periparyuient dairy cows显示文摘 | Horst R L Jardon P W Borelli C Wedam J | 1996 | Joumal of Dairy Science1996，79，3： | 1 |
| 10 | Dietary glutamine supplementation affects macrophage function, hematopoiesis and nutritional status in early weaned mice显示文摘 | Rogero M M Borelli P Vinolo M A R | 2008 | Clinical Nutrition2008，27，3： | 1 |
| 11 | Immediate loading implants:a clinical reportOf 1301 implants显示文摘 | Hruska A Borelli P Bordanaro AC | 2002 | J Oral Implantol2002，28，4： | 1 |
| 12 | Influence ofdisease activity and ehronicity on ankylosing spondy|i- tis bone mass loss显示文摘 | Meirelles E S Borelli A Camargo 0 P | 1999 | Clin Rheumatol1999，，： | 1 |
| 13 | Quality criteria for pure titanium, laboratory soldering intraoral welding, and a device aid in making uncontaminated castings 显示文摘 | Borelli P | | J Prosthet Dent0，66，4： | 1 |
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