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| 1 | Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging显示文摘AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical imaging.METHODS: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(MPO) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and MPO levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 DSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting MPO, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P < 0.005). ELISA confirmed that MPO levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. Moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and ROS production in tumors before tumor growth. Moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/DSS).CONCLUSION: Using BLI and fluorescence optical imaging, we provided tools to better understand hostpathogen interactions at the early stage of disease, such as inflammatory bowel disease and colorectal cancer. | Julie Veziant Johan Gagnière Elodie Jouberton Virginie Bonnin Pierre Sauvanet Denis Pezet Nicolas Barnich Elisabeth Miot-Noirault Mathilde Bonnet | 2016 | World Journal of Clinical Oncology2016，7，3： | 10 |
| 2 | A Concept of Dynamically Reconfigurable Real-time Vision System for Autonomous Mobile Robotics显示文摘这篇论文描述被奉献在移动式机器人被嵌入的视觉系统的特定的限制。如果因为它的通用性,灵活性,性能,和费用,基于 PC 的硬件体系结构在这域里是方便的,当前的实时操作系统完全没被改编渴望与改变持续时间处理,并且它对经常必要太大保证设有自动保险装置的工作的系统。另外,和有更多的优先级的另外的机器的任务的相互作用是困难的处理。回答这个问题,我们发展了一动态地交换子可计算的视觉处理系统,基于有关安排和容错的 Cl é opatre 即时可适用的层的创新特征。这个框架允许定义紧急情况和可选的任务为机器人的另外的分系统保证最小的服务质量,当允许动态地改编处理链到的视觉时一在持续视觉过程或处理器超载上非凡。因此,它在单个硬件允许几个分系统的更好的同居,并且他们将为常规盒子并且不被设计开发不太昂贵却安全的系统,,稀罕的非凡的。最后,认为并且发展视觉系统带一个新方法,与一些求反运算符。 | Aymeric De Cabrol Thibault Garcia Patrick Bonnin Maryline Chetto | 2008 | International Journal of Automation and computing2008，5，2： | 3 |
| 3 | In vitro gastrointestinal digestion study of two wheat cultivars and evaluation of xylanase supplementation显示文摘Background:The filamentous fungus Talaromyces versatilis is known to improve the metabolizable energy of wheatbased poultry diets thanks to its ability to produce a pool of CAZymes and particularly endo-β(1,4)-xylanases.In order to appreciate their in vivo mode of action,the supplementation effect of two of its xylanases,XynD and XynB from families GH10 and GH11 respectively,have been evaluated on two different wheat cultivars Caphorn and Isengrain,which were chosen amongst 6 varieties for their difference in non starch polysaccharides content and arabinoxylan composition.Results:Polysaccharides digestion was followed during 6 h along the digestive tract using the TNO gastrointestinal model-1,to mimic monogastric metabolism.Polysaccharide degradation appeared to occur mainly at the jejunal level and was higher with Isengrain than with Caphorn.For both cultivars,XynD and XynB supplementation increased notably the amount of reducing end sugars into the jejuno-ileal dialysates,which has been confirmed by a valuable increase of the soluble glucose into the jejunal dialysates.Conclusions:The amounts of arabinose and xylose into the dialysates and ileal deliveries increased consequently mainly for Caphorn,suggesting that XynD and XynB supplementation in wheat-based diet could alleviate the anti-nutritional effects of arabinoxylans by limiting the physical entrapment of starch and could increase the available metabolizable energy. | Mickael Lafond Bernard Bouza Sandrine Eyrichine Friedrich Rouffineau Luc Saulnier Thierry Giardina Estelle Bonnin Aurélie Preynat | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 2 |
| 4 | Arthroscopic reconstruction of the posterior cruciate ligament using double-bundle and tibial-inlayteeh- nique显示文摘 | Bonnin Kin SJ | 2012 | The Traumatic Knee2012，33，： | 1 |
| 5 | Mapping sugar beet pectin acetylation B pattern 显示文摘 | Ralet M C Cabrera J C Bonnin E | 2005 | Phytochernistry2005，66，15： | 1 |
| 6 | Injury to the ligaments of the ankle显示文摘 | Bonnin JG | 1965 | J Bone Joint Surg(Br)1965，47，4： | 1 |
| 7 | Release of ferulic acid from agroindustrial by-products by the cell wall-degrading enzymes produced by Aspergillus niger I-1472显示文摘 | Bonnin E SaulnierL Brunel M | 2002 | Enzyme and Microbial Technology2002，31，： | 1 |
| 8 | Genetic support and diversity of acquired extended-spectrum β-1actamases in Gram- negative rods显示文摘 | Poirel L Bonnin R A Nordmann P | 2012 | Infect Genet Evol2012，12，5： | 1 |
| 9 | Biometry of infrarenal inferior vena cava measured by cavography显示文摘 | P. Bonnichon F. Gaudard E. Ouakil P. Lebozec C. Labrouhe A. Bonnin C. Aaron Y. Chapuis | 1989 | Surgical and Radiologic Anatomy1989，，2： | 1 |
| 10 | Geostatistical modelling of spatial distribution of Balaenoptera physalus in the Northwestern Mediterranean Sea from sparse count data and heterogeneous observation efforts显示文摘 | Monestiez P Dubroca L Bonnin E | 2006 | Ecological Modelling2006，193，3： | 1 |
| 11 | Comparison of a propofol target controlled infusion and inhalational sevoflurane for fibreoptic intubation under sponta-neous ventilation显示文摘 | Bonnin M Therre P Albuisson E | 2007 | Acta Anaesthesiol Seand2007，51，1： | 1 |
| 12 | Collagen synthesis and content in right ventricular hypertrophy in the dog显示文摘 | Bonnin CM Sparrow MP Taylor RR | 1981 | AmPhysiol1981，10，： | 1 |
| 13 | A novel multi-domain mucin-like glycoprotein of Cryptosporidium parvum mediates invasion显示文摘 | Barnes DA Bonnin A Huang JX | 1998 | Mol Biochem Parasitol1998，96，12： | 1 |
| 14 | Comparison of a propofol target - controlled infusion and inhalational sevoflurane for fibreoptic intubation under spontaneous ventilation显示文摘 | Bonnin M Therree P Albuisson E | 2007 | Aeta Anaesth Scand2007，51，1： | 1 |
| 15 | Sex hormone status and bone mineral density in men with rheumatoid arthritis显示文摘 | Mateo L Nolla JM Bonnin MR | 1995 | Rheumatology1995，22，8： | 1 |
| 16 | Continuous patient - controlled epidural infusion of evobupivacaine plus sufentanil in labouring primiparous women: effects of concentration 显示文摘 | Tixier S Bonnin M Bolandard F | 2010 | Anaesthesia2010，65，6： | 1 |
| 17 | A biotechnological process involving filamentous fungi to produce natural crystalline vanillin from maize bran 显示文摘 | Lesage-Meessen L Lomascolo A Bonnin E | 2002 | Appl Biochem Biotechnol2002，10，2103： | 1 |
| 18 | Diabetic microangiopa- thy: impact of impaired cerebral vasoreactivity and delayed an- giogenesis after permanent middle cerebral artery occlusion on stroke damage and cerebral repair in mice 显示文摘 | Poittevin M Bonnin P Pimpie C | 2015 | Diabetes2015，64，3： | 1 |
| 19 | ERCOFTAC workshop on data bases and testing of calculation methods for turbulent flows显示文摘 | Bonnin J C Buchel T Rodi W | 1996 | ERCOFTAC Bulletin 281996，1996，： | 1 |
| 20 | Effect of catalyst on electrolysis of ammonia effluents 显示文摘 | Bonnin E P Biddinger E J Botte G G | 2008 | J Power Sources2008，182，1： | 1 |
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