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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | Gestion des grossesses avec un utérus cicatriciel : état des connaissances显示文摘 | C. Bonneau J. Nizard | 2012 | Journal de Gynecologie Obstetrique et Biologie de la Reproduction2012，，6： | 2 |
| 3 | Polyamines and related enzymesin rice seeds differing in germination potential显示文摘 | BONNEAU L CARRE M TANGUY J M | 1994 | Plant Growth Regula-tion1994，15，： | 1 |
| 4 | Polynomial surfaces interpolating arbitrary triangulations 显示文摘 | Hahmann S Bonneau G P | 2003 | IEEE Transactions on Visualization and Computer Graphics2003，9，1： | 1 |
| 5 | Relative development of subcutaneous, intermuscular, and kidney fat in growing pigs with different body compositions显示文摘 | Kouba M Bonneau M Noblet J | 1999 | Journal of Ani- mal Science1999，77，： | 1 |
| 6 | Genetic and metabolic aspectsof androstenone and skatole deposition in pig adipose tissue : areview显示文摘 | Robic A Larzul C Bonneau M | 2008 | EDP Sciences2008，40，1： | 1 |
| 7 | Influence of the roughness model on thethermoelastohydrodynamic performances of lip seals 显示文摘 | Hajjam M? Bonneau D | 2006 | TribologyInternational2006，39，3： | 1 |
| 8 | Mechanical Properties and Durability of Two Industrial Reactive Powder Concretes显示文摘 | Bonneau O Lachemi M Dallaire E | 1997 | ACI Mater J1997，94，4： | 1 |
| 9 | Management of bone metastases显示文摘 | BONNEAU A | 2008 | Can Fam Physician2008，54，4： | 1 |
| 10 | Polyamine metabolism duringseeding development显示文摘 | BONNEAU L CARRE M DREUMONT C | 1994 | Plant Growth Regulation1994，15，： | 1 |
| 11 | Influence of thermal and elastic deformations on connecting-rod big end bearing lubrication under dynamic loading显示文摘 | Piffeteau S Souchet D Bonneau D | 2000 | Journal of Tribology2000，122，： | 1 |
| 12 | Predictive markers of chemoresistance in advanced stages epithelial ovarian carcinoma显示文摘 | Bonneau C Rouzier R Geyl C | 2015 | Gynecol Oncol2015，136，1： | 1 |
| 13 | Mechanical Properties and Durability of Two Industrial Reactive Powder Concretes显示文摘 | Olivier Bonneau Mohamed Lachemi Eric DaUaire | 1997 | ACI Materials Journal1997，94，4： | 1 |
| 14 | Volume preservation of multiresolution meshes 显示文摘 | Sauvage B Hahmann S Bonneau G P | 2007 | Computer Graphics Forum2007，26，3： | 1 |
| 15 | Mechanisms underlying chemical sympa-thectomy-induced suppression of herpes simplex virus- specific cytotoxic T lymphocyte activation and function显示文摘 | Leo NA Bonneau RH | 2000 | Journal of Neuroimmunology2000，110，： | 1 |
| 16 | Reactive Powder Concrete: from Theory to Practice显示文摘 | Bonneau O Poulin C | 1996 | Concrete International1996，18，4： | 1 |
| 17 | Relationship between fat and plasma androstenone and plasma testosterone in fatty and clean young boars follwing castration显示文摘 | Bonneau M Meusy-Dessolle N | 1982 | Acta Endocrinologica (Copenhagen)1982，101，： | 1 |
| 18 | 查看详情显示文摘 | Drew K Renfrew P. D Craven T. W Butterfoss G.L. Chou F.C. Lyskov S. Bullock B.N. Watkins A. Labonte J.W. Pacella M. Kilambi K.P. Leaver-Fay A. Kuhlman B. Gray J.J. Bradley P. Kirshenbaum K. Arora P.S. Das R. Bonneau R | | 0，，7： | 1 |
| 19 | IL-17,produced by lymphocytes and neutrophils,is necessary for lipopolysaccharide-induced airway neutrophilia:IL-15 as a possible trigger显示文摘 | Ferretti S Bonneau O Dubois GR | 2003 | J Immunol2003，170，4： | 1 |
| 20 | CA125 kinetic pa-rameters predict optimal cytoreduction in patients with ad- vanced epithelial ovarian cancer treated with neoadjuvant chem- otherapy 显示文摘 | Pelissier A Bonneau C Chereau E | 2014 | Gynecol Oncol2014，135，3： | 1 |
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