|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Precision medicine in gastric cancer显示文摘Gastric cancer(GC)is a complex disease linked to a series of environmental factors and unhealthy lifestyle habits,and especially to genetic alterations.GC represents the second leading cause of cancer-related deaths worldwide.Its onset is subtle,and the majority of patients are diagnosed once the cancer is already advanced.In recent years,there have been innovations in the management of advanced GC including the introduction of new classifications based on its molecular characteristics.Thanks to new technologies such as next-generation sequencing and microarray,the Cancer Genome Atlas and Asian Cancer Research Group classifications have also paved the way for precision medicine in GC,making it possible to integrate diagnostic and therapeutic methods.Among the objectives of the subdivision of GC into subtypes is to select patients in whom molecular targeted drugs can achieve the best results;many lines of research have been initiated to this end.After phase III clinical trials,trastuzumab,anti-Erb-B2 receptor tyrosine kinase 2(commonly known as ERBB2)and ramucirumab,anti-vascular endothelial growth factor receptor 2(commonly known as VEGFR2)monoclonal antibodies,were approved and introduced into first-and second-line therapies for patients with advanced/metastatic GC.However,the heterogeneity of this neoplasia makes the practical application of such approaches difficult.Unfortunately,scientific progress has not been matched by progress in clinical practice in terms of significant improvements in prognosis.Survival continues to be low in contrast to the reduction in deaths from many common cancers such as colorectal,lung,breast,and prostate cancers.Although several target molecules have been identified on which targeted drugs can act and novel products have been introduced into experimental therapeutic protocols,the overall approach to treating advanced stage GC has not substantially changed.Currently,surgical resection with adjuvant or neoadjuvant radiotherapy and chemotherapy are the most effective treatments for this disease.Future research should not underestimate the heterogeneity of GC when developing diagnostic and therapeutic strategies aimed toward improving patient survival. | Patrizia Bonelli Antonella Borrelli Franca Maria Tuccillo Lucrezia Silvestro Raffaele Palaia Franco Maria Buonaguro | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 8 |
| 2 | UKCP:a collaborative network of cerebral palsy registers in the United Kingdom显示文摘 | Surman G Bonellie S Chalmers J | 2006 | J Public Health2006，28，2： | 1 |
| 3 | Early tracheostomy versus late tracheostomy in the surgical intensive care unit显示文摘 | MOLLER M G SLAIKEU J D BONELLI P | 2005 | Am J Surg2005，189，3： | 1 |
| 4 | Novel partitioned time integration methods for DAE systems based on L- stable linearly implicit algorithms 显示文摘 | Jia C Bursi O Bonelli A | 2011 | International Journal for Numerical Methods in Engineering2011，87，12： | 1 |
| 5 | Early tracheosto-my versus late tracheostomy in the surgical intensive care unit显示文摘 | Moller MG Slaikeu JD Bonelli P | | 0，，3： | 1 |
| 6 | In situ infrared study of SBA-15 functionalized with carboxylic groups incorporated by a co-conden-sation route 显示文摘 | Fiorilli S Onida B Bonelli B | 2005 | Journal of Physical Chemistry B2005，109，16： | 1 |
| 7 | Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice显示文摘 | Bluml S Bonelli M Niederreiter B | 2011 | Arthritis Rheum2011，63，5： | 1 |
| 8 | Accessibility of the functional groups of chitosan aerogel probed by FT - IR - monitored deuteration 显示文摘 | -alentin R Bonelli B | 2007 | Biomacromolecules2007，8，： | 1 |
| 9 | Adrenocorti- cotropic hormone-dependent Cushing's syndrome: sensitivity and specificity of inferior petrosal sinus sampling 显示文摘 | Bonelli FS Huston Iii J Carpenter PC | 2000 | AJNR Am J Neuroradio2000，21，4： | 1 |
| 10 | Phenotypic and functional analysis of CD4^+ CD25^-Foxp3^+ T cells in patients with systemic lupus erythematosus显示文摘 | Bonelli M Savitskaya A Steiner CW | 2009 | J Immunol2009，182，3： | 1 |
| 11 | Foxp3 expression in CD4 + T cells of patients with systemic lupus erythematosus (SLE) : A comparative phenotypie analysis 显示文摘 | Bonelli M von Dalwigk K Savitskaya A | 2008 | Ann Rheum Dis2008，67，5： | 1 |
| 12 | Hippocampal activation correlates with visual confrontation naming fMRI findings in controls and patients with temporal lobe epilepsy 显示文摘 | Silvia B Bonelli Rob Powell | 2011 | Epilepsy Research2011，95，3： | 1 |
| 13 | Adsorp- tion of volatile organic compounds onto activated carbon cloths derived from a novel regenerated cellulosic precursor显示文摘 | RAMOS M E BONELLI P R CUK1ERMAN A L | 2010 | Journal of Hazard- ous Materials2010，177，13： | 1 |
| 14 | Adsorption of volatile organic compounds onto activated carbon cloths derived from a novel regenerated cellulosic precursor显示文摘 | RAMOS M E BONELLI P R CUKIENMANA L | | 0，，1： | 1 |
| 15 | Clinical seizure later-alization in frontal lobe epilepsy显示文摘 | Bonelli SB LurgerS ZimprichF | 2007 | Epilepsia2007，48，3： | 1 |
| 16 | Pharmacological management of Hun- tington's disease: an evidence-based review显示文摘 | Bonelli RM Wenning GK | 2006 | Curt Pharm Des2006，12，21： | 1 |
| 17 | Effects of Gamma Knife radio-surgery of pituitary adenomas on pituitary function显示文摘 | Feigl GC Bonelli CM | 2004 | J Neurosurg2004，97，5： | 1 |
| 18 | Abatacept(CTLA-4IG)treatment reduces the migratory capacity of monocytes in patientswith rheumatoid arthritis 显示文摘 | Bonelli M Femer E Goschl L | 2013 | A rthritis Rheum2013，65，3： | 1 |
| 19 | Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy显示文摘 | FLYNN R W BONELLIE S R JUNG R T | 2010 | J Clin Endocrinol Metab2010，95，： | 1 |
| 20 | A systematic review of the treatment studies in Huntington's disease since 1990显示文摘 | Bonelli RM Hofmann P | 2007 | Expert Opin Phar- macother2007，8，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员