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	题名	作者	年代	出处	被引量
1	“Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases显示文摘Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis regulation is the never in mitosis-gene A(NIMA)-related kinases(Neks). The founding member of this family is the sole member NIMA of Aspergillus nidulans, which is crucial for the initiation of mitosis in that organism. All 11 human Neks have been functionally assigned to one of the three core functions established for this family in mammals:(1) centrioles/mitosis;(2) primary ciliary function/ciliopathies; and(3) DNA damage response(DDR). Recent findings, especially on Nek 1 and 8, showed however, that several Neks participate in parallel in at least two of these contexts: primary ciliary function and DDR. In the core section of this in-depth review, we report the current detailed functional knowledge on each of the 11 Neks. In the discussion, we return to the cross-connections among Neks and point out how our and other groups' functional and interactomics studies revealed that most Neks interact with protein partners associated with two if not all three of the functional contexts. We then raise the hypothesis that Neks may be the connecting regulatory elements that allow the cell to fine tune and synchronize the cellular events associated with these three core functions. The new and exciting findings on the Nek family open new perspectives and should allow the Neks to finally claim the attention they deserve in the field of kinases and cell cycle biology.	Gabriela Vaz Meirelles Arina Marina Perez Edmárcia Elisa de Souza Ferna Luisa Basei Priscila Ferreira Papa Talita Diniz Melo Hanchuk Vanessa Bomfim Cardoso Jrg Kobarg	2014	World Journal of Biological Chemistry2014，5，2：	2
2	Prog- nostic significance of TIMP3 hypermethylation in post - treat- ment salivary rinse from head and neck squamous cell carcino- ma patients显示文摘	Rettori MM de Carvalho AC Bomfim Longo AL	2013	Carcinogenesis2013，34，1：	1
3	Toll-like recep- tor 4 contributes to blood pressure regulation and vascular con- traction in spontaneously hypertensive rats显示文摘	Bomfim GF Dos Santos RA Oliveira MA	2012	Clinical Science2012，122，11：	1
4	Simultaneous tuning of power system damping controllers using genetic algorithms显示文摘	DO BOMFIM A L B TARANTO G N FALCAO D M	2000	IEEE Trans on Power Systems2000，15，1：	1
5	Resistance markers and gene- tic diversity in Acinetobacter baumannii strains recovered from nosocomial bloodstream infections显示文摘	Martins HS Bomfim MR Franga RO	2014	Int J Environ Res Public Health2014，11，2：	1
6	Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats显示文摘	Bomfim GF Dos Santos RA Oliveira MA	2012	Clin Sci (Lond)2012，122，11：	1
7	An anti-dia-betes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease-associated Abeta oligomers显示文摘	Bomfim TR Forny-Germano L Sathler LB	2012	J Clin Invest2012，122，4：	1
8	MRI findings in the painful hemiplegic shoulder显示文摘	Távora D Gama R Bomfim R	2010	Clinical Radiology2010，65，10：	1
9	Mutual evaluation of global gravity models (EGM2008 and GOCE ) and terrestrial data in Amazon Basin, Brazil 显示文摘	Bomfim E P Braitenberg C Molina E C	2013	Geophysical Journal International2013，195，2：	1
10	Protec- tion of synapses against Alzheimer' s-linked toxins: Insulin signaling prevents the pathogenic binding of A beta oli- gomers 显示文摘	DEFELICE FG VIEIRA MN BOMFIM TR	2009	PNAS2009，106，6：	1
11	Resistance markers and genetic diversity in Acinetobacter baumannii strains recovered from nosocomial bloodstream infections显示文摘	Martins HS Bomfim MR Franca RO	2014	Int J Environ Res Public Health2014，11，2：	1
12	Simultaneous tuning of power system damping controllers using genetic algorithms显示文摘	Do Bomfim A L B Taranto G N Falcao D M		0，，01：	1
13	The influence of perivascular adipose tissue on vascular homeostasis显示文摘	Szasz T Bomfim GF Webb RC		0，，：	1
14	Simultaneous tuning of power system damping controllers using genetic algorithms 显示文摘	do BOMFIM A L B TARANTO G N FALCAO D M	2000	IEEE Trans on Power Systems2000，15，1：	1
15	Toll like receptor 4 in- hibition reduces vascular inflammation in spontaneously hyperten sive rats显示文摘	Bomfim GF Echem C Martins CB	2015	Life Sci2015，122，：	1
16	An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers显示文摘	Bomfim TR Forny-Germano L Sathler LB	2012	J Clin Invest2012，122，：	1
17	Design of a pipeline leakage detection using expert system: A novel approac显示文摘	Laurentys C A Bomfim C H M Menezes B R	2011	Applied Soft Computing Journal2011，11，1：	1
18	Sim- ultaneous Tuning of Power System Damping Controller Using Genetic Algorithms 显示文摘	DO BOMFIM A L B TARANTO G N FALCAO D M	2000	IEEE Transactions on Power Sys- tems2000，15，1：	1
19	Sleep disturbances and brain MRI morphometry in Parkinson' s disease, multiple system atrophy and progressive supranuclear palsy-a comparative study 显示文摘	Gama RL T6vora DG Bomfim RC	2010	Parkinsonism Relat Disord2010，16，4：	1
20	Cytotoxic Effect of Leaf Essential Oil of LippiaGracilis Schauer ( Verbenaceae) 显示文摘	FERRAZ R P BOMFIM D S CARVALHO N C etal	2013	Phytomedicine2013，20，7：	1

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