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| 1 | Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion显示文摘Development of a novel in vivo lung perfusion(IVLP)procedure allows localized delivery of high-dose doxorubicin(DOX)for targeting residual micrometastatic disease in the lungs.However,DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window.A small dimension nitinol wire coated with a sorbent of biocompatible morphology(Bio-SPME)has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key metabolites.The in vivo Bio-SPME-IVLP experiments were performed on pig model over various(150 and 225 mg/m^(2))drug doses,and during human clinical trial.Two patients with metastatic osteosarcoma were treated with a single 5 and 7 μg/mL(respectively)dose of DOX during a 3-h IVLP.In both pig and human cases,DOX tissue levels presented similar trends during IVLP.Human lung tissue concentrations of drug ranged between 15 and 293 μg/g over the course of the IVLP procedure.In addition to DOX levels,Bio-SPME followed by liquid chromatography-mass spectrometry analysis generated 64 metabolic features during endogenous metabolite screening,providing information about lung status during drug administration.Real-time monitoring of DOX levels in the lungs can be performed effectively throughout the IVLP procedure by in vivo Bio-SPME chemical biopsy approach.Bio-SPME also extracted various endogenous molecules,thus providing a real-time snapshot of the physiology of the cells,which might assist in the tailoring of personalized treatment strategy. | Barbara Bojko Nikita Looby Mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz Pedro Reck dos Santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell German Goomez-Rios Marcos Tascon Krzysztof Gorynski Marcelo Cypel Janusz Pawliszyn | 2021 | Journal of Pharmaceutical Analysis2021，11，1： | 3 |
| 2 | Competitive binding of phenylbutazone and colchicine to serum albumin in multidrug therapy显示文摘 | SULKOWSKA A MACIAZEK-JURCZYK M BOJKO B | 2008 | J Mol Struct2008，881，13： | 1 |
| 3 | Competitive binding of phenylbutazone and colchicine to serum albumin in multidrng therapy 显示文摘 | Sulkowska A Maciazek - Jurczyk M Bojko B | 2008 | Journal of Molecular Structure2008，881，13： | 1 |
| 4 | The influence of dietary habits and pathological conditions on the binding of theophylline to bovine serum albumin显示文摘 | BOJKO B SUKOWSKA A MACIAEK-JURCZYK M | 2009 | J Pharmaceutical and Biomedical Analysis2009，52，3： | 1 |
| 5 | The influence of dietary habits and pathological conditions on the binding of theophylline to bovine serum albumin显示文摘 | Bojko B Sutkowska A Maciaiek -Jurczyk M | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，52，3： | 1 |
| 6 | An examination of the se- quence of intersecting lines using attenucefed total reflec- tance-fourier fransform intrared spectral imaging 显示文摘 | Katherine Bojko B Sc(Hons) | 2008 | J Forensic Sci2008，53，6： | 1 |
| 7 | Competitive binding of phenylbutazone and colchicine to serum albumin in muhidrug therapy显示文摘 | Sulkowska A Maciazek-Jurczyk M Bojko B | 2008 | J Mol Struct2008，881，13： | 1 |
| 8 | The influence of dietary habits and pathological conditions on the binding of theophylline to bovine serum albumin 显示文摘 | Bojko B Sulkowska A Maciaek -Jurczyk M | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，52，3： | 1 |
| 9 | Age equivalence in switch costs for prosaccade and antisaccade tasks显示文摘 | BOJKO A KRAMER A F PETERSON M S | 2004 | Psychology and Aging2004，19，1： | 1 |
| 10 | Use of Electrocardiographic Depolarization Abnormalities for Detection of Stress-Induced Ischemia as Defined by Myocardial Perfusion Imaging显示文摘 | Tali Sharir Konstantine Merzon Iren Kruchin Andrzej Bojko Eran Toledo Arik Asman Pierre Chouraqui | 2012 | The American Journal of Cardiology2012，，5： | 1 |
| 11 | The spectrum of neuropsy-chiatric abnormalities associated with electrical status epilepticus in sleep显示文摘 | Galanopoulou AS Bojko A Lado F | 2000 | Brain Dev2000，22，5： | 1 |
| 12 | Paracetamol and cytarabine binding competition in high affinity binding sites oftransporting protein 显示文摘 | SULKOWSKA A BOJKO B ROWNICKA J | 2006 | Mol Struct2006，26，9： | 1 |
| 13 | The influence of dietary habits and pathological conditions on the binding of theophylline to serum albu- min显示文摘 | BOJKO B SULKOWSKA A MACIAZEK-JURCZYK M | 2010 | Pharm Biomed Anal2010，52，3： | 1 |
| 14 | Metabolomic fingerprinting of porcine lung tissue during pre-clinical prolonged ex vivo lung perfusion using in vivo SPME coupled with LC-HRMS显示文摘Normothermic ex vivo lung perfusion(NEVLP)has emerged as a modernized organ preservation technique that allows for detailed assessment of donor lung function prior to transplantation.The main goal of this study was to identify potential biomarkers of lung function and/or injury during a prolonged(19 h)NEVLP procedure using in vivo solid-phase microextraction(SPME)technology followed by liquid chromatography-high resolution mass spectrometry(LC-HRMS).The use of minimally invasive in vivo SPME fibers for repeated sampling of biological tissue permits the monitoring and evaluation of biochemical changes and alterations in the metabolomic profile of the lung.These in vivo SPME fibers were directly introduced into the lung and were also used to extract metabolites(on-site SPME)from fresh perfusate samples collected alongside lung samplings.A subsequent goal of the study was to assess the feasibility of SPME as an in vivo method in metabolomics studies,in comparison to the traditional inlab metabolomics workflow.Several upregulated biochemical pathways involved in pro-and antiinflammatory responses,as well as lipid metabolism,were observed during extended lung perfusion,especially between the 11th and 12th hours of the procedure,in both lung and perfusate samples.However,several unstable and/or short-lived metabolites,such as neuroprostanes,have been extracted from lung tissue in vivo using SPME fibers.On-site monitoring of the metabolomic profiles of both lung tissues through in vivo SPME and perfusate samples on site throughout the prolonged NEVLP procedure can be effectively performed using in vivo SPME technology. | Nikita Looby Anna Roszkowska Aadil Ali Barbara Bojko Marcelo Cypel Janusz Pawliszyn | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 1 |
| 15 | Plasma levels of apolipoprotein-E in residents of the European North of Russia显示文摘 | Kaneva AM Bojko ER Potolitsyna NN | | 0，，： | 1 |
| 16 | The influence of dietary habits and pathological conditions on the binding of theophylline to serum albumin显示文摘 | BOJKO B SULKOWSKA A MACIAZEK-j URCZYK M | 2010 | Pharm Biomed Anal2010，52，3： | 1 |
| 17 | Competitive binding of phenylbutazone and colchicine to serum albumin in multidrug therapy: A spectroscopic study 显示文摘 | SULKOWSKA A MACIAZEK-JURCZYK M BOJKO B | 2008 | Journal of Molecular Structure2008，881，1： | 1 |
| 18 | Fluorescence analysis of competition of phenylbntazone and methotrexate in binding to serum albumin in combination treatment in rheumatology 显示文摘 | MACIAZEK-JURCZYK M SULKOWSKA A BOJKO B | 2009 | Journal of Molecular Structure2009，924，： | 1 |
| 19 | The influence of dietary habits and pathological conditions on the binding of theophylline to bovine serum albumin显示文摘 | Bojko B Sulkowska A Maciazek-Jurczyk M | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，52，3： | 1 |
| 20 | The spectrum of neuro- psychiatric abnormalities associated with electrical status epilepticus in sleep 显示文摘 | Galanopoulou AS Bojko A Lado F | 2000 | Brain Dev2000，22，5： | 1 |
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