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| 1 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 2 | Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology 显示文摘 | Ludwig H Bode L | 2000 | Rev Sci Tech2000，19，1： | 1 |
| 3 | Boma disease virus infection, a human mental- health risk显示文摘 | Bode L Ludwig H | 2003 | Clin Microbiol Rev2003，16，3： | 1 |
| 4 | In vitro models for studying trophoblast transcellular transport显示文摘 | Bode CJ Jin H Rytting E | | 0，，： | 1 |
| 5 | A novel marker for Borna disease virus infection显示文摘 | Bode L Steinbach F Ludwig H | 1994 | Lancet1994，343，8892： | 1 |
| 6 | Frequency-domain analysis of three-phase linear current regulators显示文摘 | Zmood D N Holmes D G Bode G H | 2001 | IEEE Transactions on Industry Applications2001，37，2： | 1 |
| 7 | E 6 ]- Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase 显示文摘 | JEONG C H BODE A M PUGLIESE A | 2009 | Cancer Res2009，69，13： | 1 |
| 8 | Slimflor and slimdek construction: European developments 显示文摘 | Lawson R M Bode H Brekelmans J W P M | 1999 | The Structural Engineer1999，77，8： | 1 |
| 9 | Axis formation in hydra 显示文摘 | Bode H | 2011 | Annu Rev Genet2011，45，： | 1 |
| 10 | Biosynthesis of volatiles by the Myxobacterium Myxococcusxanthus 显示文摘 | Dickschat J S Wenzel S C Bode H B | 2004 | Journal of Biological Chemistry2004，5，6： | 1 |
| 11 | Frequency-domain analysis of three-phase linear current regulators显示文摘 | Zmood D N Holmes D G Bode G H | 2001 | IEEE Transactions on Industry Applications2001，37，2： | 1 |
| 12 | Axis formation in hydra 显示文摘 | Bode H | 2011 | Annu Rev Genet2011，45，： | 1 |
| 13 | Malignancies under cyclosporine after kidney transplantation: analysis of a 10- year period显示文摘 | Frei U Bode U Repp H | 1993 | Transplant Proc1993，25，12： | 1 |
| 14 | Structure and biosynthesis of mutolide, a novel macrolide from a UV mutant of the fungus F -24 ' 707显示文摘 | Bode H B Walker M Zeeck A | 2000 | Eur J Org Chem2000，，8： | 1 |
| 15 | Frequency-domain analysis of three-phase linear current regulators显示文摘 | Zmood D N Holmes D G Bode G H | 2001 | IEEE Transactions on Industry Applications2001，37，2： | 1 |
| 16 | Expression of coagulant activity in human platelets: release of membranous vesicles providing platelet factor 1 and factor 3显示文摘 | Sandberg H Bode AP Dombrose FA | 1985 | Thromb Res1985，39，： | 1 |
| 17 | Frequency-domain analysis of three-phase linear current regulators显示文摘 | Zmood D N Holmes D G Bode G H | 2001 | IEEE Transactions on Industry Applications2001，37，2： | 1 |
| 18 | Insects:true pioneers in anti-infective therapy and what we can learn from them显示文摘 | Bode H B | 2009 | Angew Chem Int Ed Engl2009，48，35： | 1 |
| 19 | Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding显示文摘 | BODE L KUHN L KIM H Y | 2012 | The American Journal of Clinical Nutrition2012，96，4： | 1 |
| 20 | An improved robust predictive current regulation algorithm 显示文摘 | BODE G H LOH P C NEWMAN M J | 2005 | IEEE Transactions on Industry Applications2005，41，6： | 1 |
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