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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | 先进航空材料焊接过程热裂纹研究进展显示文摘高焊接热裂纹敏感性是制约新一代合金材料在航空航天领域推广应用的技术瓶颈。本文分别从焊接热裂纹的产生机理和各类合金裂纹敏感性实验的角度梳理该方向的研究进展。焊接热裂纹主要包括凝固裂纹(在焊缝内部产生)和液化裂纹(在焊缝与部分熔化区交界处产生)。影响焊接热裂纹产生的因素包括材料成分、焊接热循环以及接头热应力。在梳理焊接热裂纹机理研究的基础上,分别总结了铝合金、镁合金、先进高强钢以及镍基合金焊接热裂纹的实验研究进展。建立考虑复杂多组元以及结晶形态对裂纹敏感性影响的量化判据,是该领域未来的重要发展方向。针对母材和焊材进行成分优化、添加形核剂或实施辅助工艺措施,是工程应用领域抑制热裂纹缺陷的有效方法。开展焊接热裂纹产生机理及其抑制方法研究,有助于突破新一代合金材料加工技术瓶颈,推进其在航空航天领域的应用。 | 李红 闫维嘉 张禹 杜文博 栗卓新 MARIUSZ Bober SENKARA Jacek | 2022 | 材料工程2022，50，2： | 9 |
| 3 | 高熵合金在钎焊和表面工程领域的应用研究进展显示文摘随着合金制造水平的提高及性能要求的复杂化,高熵合金逐渐引起极大的关注。目前在材料加工领域内的研究主要集中于钎焊和表面工程两大方向。在钎焊领域,高熵合金可以作为钎焊填充材料应用于高温和低温钎焊,本文归纳了合金高熵化的相关经验参数,阐述了第一性原理计算和相图计算等模拟计算手段在高熵合金填充材料设计领域内的应用;详细介绍了高熵合金钎料在镍基高温合金、陶瓷-金属异种材料、低温封装等连接领域的最新研究进展。同时,分析了工艺参数对高熵合金钎料钎焊接头组织与性能的影响。在表面工程领域,论述了高熵合金薄膜/涂层的应用方向与制备手段,总结了在高温防护涂层、硬质保护层以及其他应用领域的研究进展。同时归纳了高熵合金在钎焊和表面工程领域研究和应用中存在的问题,而未来将在降低钎料熔点、提高焊缝高温力学性能以及发展共晶高熵合金钎料/涂层等领域进一步提高研究水平。 | 李红 韩祎 曹健 MARIUSZ Bober JACEK Senkara | 2021 | 材料工程2021，49，8： | 7 |
| 4 | Segmenting traffic scenes from grey level and motion information显示文摘 | Badenas J Bober M Pla F | 2001 | Pattern Analysis and Applications2001，4，1： | 1 |
| 5 | Thermal degradation of joined thick Au and A1 elements显示文摘 | BOCHENEK A BOBER B HAUFFE W | 2004 | Microelectronics International2004，21，1： | 1 |
| 6 | Prevalence of anticardiolipin antibodies in type 1 diabetes and autoimmune thyroiditis显示文摘 | Abaci A Bober E Yesilkaya E | | 0，，03： | 1 |
| 7 | Senstitised decomposition of microcystin-LR using UV radiation显示文摘 | GAJDEK P BOBER B MEJ E | 2004 | Journal of Photochemistry and Photobiology B2004，76，： | 1 |
| 8 | Transcriptional activation domain of the muscle-specific gene-regulatory protein myf5 显示文摘 | Braun T Winter B Bober E | 1990 | Nature1990，346，16： | 1 |
| 9 | MPEG-7 Visual Shape Descriptors显示文摘 | Bober M | 2001 | IEEE Trans on Circuit and Systems for Video Technology2001，11，6： | 1 |
| 10 | Image Processing-based Methodology for Optimizing Automotive Ignition Timing显示文摘 | Bober T Shih F Y | | 0，，01： | 1 |
| 11 | Prevalence of anticardiolipin an- tibodies in type 1 diabetes and autoimmune thyroiditis 显示文摘 | Abaci A Bober E Yesilkaya E | 2010 | Pol Arch Med Wewn2010，120，3： | 1 |
| 12 | Adrenal myelolipoma 6 cases and a review of the literature 显示文摘 | WAGNEROVA H LAZUROVA I BOBER J | 2004 | Neoplasma2004，51，： | 1 |
| 13 | MPEG-7 visual shape descriptors显示文摘 | BOBER M | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，6： | 1 |
| 14 | Netrin 1 is re- quired for semicircular canal formation in the mouse inner ear 显示文摘 | SALMINEN M MEYER B I BOBER E | 2000 | Development2000，127，1： | 1 |
| 15 | MPEG-7 Visual Shape Descriptors显示文摘 | Miroslaw Bober | 2001 | IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY2001，11，6： | 1 |
| 16 | 显示文摘 | Maltsev V Bober E | 1994 | Dev Biol1994，164，： | 1 |
| 17 | In vitro and in vivo ef- fects of fluoride ions on enzyme activity 显示文摘 | Adamek E Pawiowska-Goral K Bober K | 2005 | Ann Acad Med Stetin2005，51，2： | 1 |
| 18 | Image processing-based methodology for op- timizing automotive ignition timing 显示文摘 | BOBER T SHIH F Y | 2009 | IEEE Transactions on Ve- hicular Technology2009，58，1： | 1 |
| 19 | Developmental patterns in the expression of Myf-5,MyoD,myogenin,and MRF4 during myogenesis显示文摘 | Montarras D Chelly J Bober E | 1991 | New Biol1991，3，6： | 1 |
| 20 | Polyaniline-silver com-posites prepared by the oxidation of aniline with silver nitrate in so-lutions of sulfonic acids 显示文摘 | BOBER P TRCHOVA M PROKES J | | Electrochemical Acta0，，10： | 1 |
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