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| 1 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Correlations between traffic, occupational, sports, and home accidents 显示文摘 | SALMINEN S HEISKANEN M | 1997 | Accid Anal Prev1997，29，1： | 1 |
| 3 | Probiotics in primary prevention of atopic disease:a randomised placebo-controlled trial显示文摘 | KALLIOMKI M SALMINEN S ARVILOMMI H | 2001 | The Lancet2001，357，9262： | 1 |
| 4 | Absence of hose specificity for in vitro adhesion of pro-biotic lactic acid bacteria to intestinal mucus显示文摘 | Rinkinen M Westermarck E Salminens O U | 2003 | VetMicrobiol2003，97，12： | 1 |
| 5 | Absence of hose specificity for in vitro adhesion of probiotic lactic acid bhacteria to intestinal mucus显示文摘 | Rinhinen M Westermarck E Salminens OU wehand A C | 2003 | Vet Microbiol2003，97，12： | 1 |
| 6 | Risk for subsequent coronary artery disease after preeclampsia 显示文摘 | Haukkamaa L Salminen M Laivuori H | 2004 | Am J Cardiol2004，93，： | 1 |
| 7 | AMP-activated protein ki- nase inhibits NF-KB signaling and inflammation: impact on health- span and lifespan显示文摘 | Salminen A Hyttinen J M Kaarniranta K | 2011 | Mol Med2011，89，7： | 1 |
| 8 | Withdrawal of psy- chotropic drugs decreases the risk of falls requiring treatment 显示文摘 | Salonoja M Salminen M Vahlberg T | 2012 | Arch Gerontol Geriatr2012，54，1： | 1 |
| 9 | Chemical ecology of tannins and other phenolics:we need a change in approach显示文摘 | Salminen J P Karonen M | | 0，，： | 1 |
| 10 | Specif- ic strains of probiotic bacteria are efficient in removal of several different eyanobacterial toxins from solution 显示文摘 | Nybom S M K Salminen S J Meriluoto J A O | 2008 | Toxicon2008，52，2： | 1 |
| 11 | Probiotics in adhe- sion of pathogens: mechanisms of action显示文摘 | Collado M C Gueimonde M Salminen S | 2010 | Bio Food Pro Hea2010，23，： | 1 |
| 12 | Laser welding and weld hardness analysis of thick section $355 structural steel 显示文摘 | Sokolov M Salminen A Kuznetsov M | 2011 | Materials and Design2011，32，6： | 1 |
| 13 | Probioties in primary prevention of atopic disease: a randomized placebo-controlled trical 显示文摘 | Kulliomaki M Salminen S Arvilommi H | 2001 | Lancet2001，357，9262： | 1 |
| 14 | Functional food Science and Gastrointestinal Physiology and Function显示文摘 | SALMINEN S BOULEY M C BOUTRON-RUALT M C | 1998 | Br J Nutr Suppl1998，1，： | 1 |
| 15 | Probiotics in primaryprevention of atopic disease : a randomized placebo controlled trial显示文摘 | Kalliomaki M Salminen S Kero P | 2001 | Lancet2001，357，： | 1 |
| 16 | Responses of microbial activity and de composer organisms to contamination in microcosms containing coniferous forest soil显示文摘 | Salminen J Liiri M Haimi J | 2002 | Ecotoxicol Environ Safety2002，53，1： | 1 |
| 17 | Development of selection criteria for probiotic strains to assess their potential in functional foods:a Nordic and European approach 显示文摘 | Salminen S Laine M Wright A V | 1996 | Bioscience Microflora1996，15，2： | 1 |
| 18 | Myotube-specific activity of the human aldolase A M-promoter requires an overlapping binding site for NF1 and MEF2 factors in addition to a binding site(M1) for unknown proteins显示文摘 | Salminen M Spitz F Fiszman MY Demignon J Kahn A Daegelen D Maire P | | 0，，01： | 1 |
| 19 | Mat- uration of autophagosomes and endosomes : a key role for Rab7 显示文摘 | HYTTINEN J M NIITFYKOSKI M SALMINEN A | 2013 | Biochim Biophys Acta2013，1833，3： | 1 |
| 20 | Up-regulation of cartilage oligomeric matrix protein at the onset of articular cartilage degeneration in a transgenic mouse model of osteoarthritis 显示文摘 | Salminen H Perl M Lorenzo P | 2000 | Arthritis Rheum2000，43，8： | 1 |
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