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| 1 | 正常高值血压者心脏迷走神经调节、氧化应激和心血管疾病危险因素的横断面研究显示文摘高血压是心血管疾病的可控危险因素之一,与氧化应激增强和心脏迷走神经调节减弱相关。同样,正常高值血压也与心血管事件的风险增加相关。该研究探索正常高值血压和心脏迷走神经调节、氧化应激及心血管危险因素之间的相关性。 | Thiyagarajan R Pal P Pal GK Subramanian SK Bobby Z Das AK Trakroo M 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，9： | 5 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | Update:the diagnosis andmanagement of dengue virus infection in North America显示文摘 | William F W Bobbi S P | 2012 | Diagn Micro Infec Dis2012，73，： | 1 |
| 4 | Shear modulus and damping in soils:measurement and parameter effects显示文摘 | Bobby O H Vincent P D | 1972 | Journal of the Soil Mechanics and FoundationDivision ASCE1972，98，6： | 1 |
| 5 | An Improved Optimization Algorithm and a Bayes Factor Termination Criterion for Sequential Projection Pursuit显示文摘 | Bobbie J M Webb-Robertson Kristin H J Scott D H Christian P Bob W W | 2005 | Chemometrics and Intelligence Laboratory Systems2005，77，12： | 1 |
| 6 | Hyperhomocysteinemia, insulin resistance and high hs-CRP levels in prehypertension 显示文摘 | Talikoti P Bobby Z Hamide A | 2014 | J Chn Diagn Res2014，8，8： | 1 |
| 7 | Shear Modulus and Damping in Soils:Measurement and Parameter Effects显示文摘 | Vincent P Drenevich | 1972 | Journal of the Soil Mechanics and Foundation Division ASCE1972，98，6： | 1 |
| 8 | Duration of lacta- tion is associated with lower prevalence of the metabolic syndrome in midlife--SWAN, the study of women's health across the nation 显示文摘 | Ram KT Bobby P Hailpern SM | 2008 | Am J Obstet Gynecol2008，198，3： | 1 |
| 9 | Shear modulus and damp ing in soils: measurement and parameter effects显示文摘 | Bobby O H Vincent P D | 1972 | Journal of the Soil Mechanics and Foundations Divi sion ASCE1972，98，6： | 1 |
| 10 | Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics显示文摘BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer cases.Data are conflicting on the role of IGBC diagnosis in oncological outcomes.Some studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others not.AIM To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative intent.METHODS Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary centre.Statistical comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was performed.Survival analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank test.Risk analysis was performed with univariable and multivariable Cox regression analysis.RESULTS The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC ones.OS was longer in patients with IGBC in the whole cohort(29 vs 4 mo,P<0.001),as well as in the non-surgical(14 vs 2 mo,P<0.001)and surgical subgroups(29 vs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and DFS.NIGBC diagnosis was identified as an independent predictor of OS.CONCLUSION IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour characteristics.Prospective studies are required to further investigate this,including detailed pathological analysis and molecular gene expression. | Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 11 | Case Based Learning Versus Problem Based Learning: A Direct Comparison from First Year Medical Students Perspective 显示文摘 | Setia S Bobby Z Ananthanamyanan P | 2011 | Web med Central2011，2，6： | 1 |
| 12 | Hyperhomocysteinemia, InsulinResistance and High HS-CRP Levels in Prehypertension显示文摘 | Talikoti P Bobby Z Hamide A | 2014 | J ClinDiagn Res2014，8，8： | 1 |
| 13 | High dose astaxanthin lowersblood pressure and increases insulin sensitivity in rats: are these effectsinterdependent?显示文摘 | HARRY G P BOBBY E EIJI Y | 2011 | International Journal of Medical Sciences2011，8，2： | 1 |
| 14 | Inhibition of Aspergillus flavus in soil by antagonistic Pseudomonas strains reduces the potential for airborne ppore dispersal 显示文摘 | JEFFREY D P TERESA L O ALl K HAMED K A BOBBIE J J | 2010 | Phy- topathology2010，100，6： | 1 |
| 15 | Flow injection potentiometric determination of phosphate in waste waters and fertilisers using a cobalt wire ion-sdective electrode 显示文摘 | Roland D M Bobby P Chert Zuliang | 1998 | The Analyst1998，123，： | 1 |
| 16 | Shear modulus and damping in soils:measurement and parameter effects显示文摘 | Bobby O Hardin Vincent P Drnevich | 1972 | Journal of the Soil Mechanics and Foundations Division ASCE1972，98，6： | 1 |
| 17 | Shear Modulus and Damping in Soils:Measurement and Parameter Effects显示文摘 | BOBBY O H VINCENT P D | 1972 | Journal of the Soil Mechanics and Foundations Division ASCE1972，98，6： | 1 |
| 18 | Shear modulus and damping in soils design equations and curves显示文摘 | Hardin Bobby O Vincent P Drnevich | | 0，，7： | 1 |
| 19 | Estimation of ocean surface currents beyond the region of overlap of dual-site HF radar 显示文摘 | | 2003 | IEEE Journal of Oceanic Engineering2003，18，4： | 1 |
| 20 | Shear modulus and damping in soils: measurement and parameter effects显示文摘 | Bobby O H Vincent P D | 1972 | Journal of the Soil Mechanics and Foundations Division ASCE1972，98，6： | 1 |
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