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| 1 | A single center investigation of bare-metal or drug-eluting stent restenosis from 1633 consecutive Chinese Han ethnic patients显示文摘Background Stents are widely used in China but the clinical impression is somehow that restenosis is less common because of the lower prevalence of coronary artery disease (CAD) and associated risk factors in Chinese populations. However, no large-sample published studies are available on angiographic stent restenosis including those of bare-metal stent (BMS) or drug-eluting stent (DES) in Chinese Han ethnic population. Mothods A total of 1633 consecutive patients with CAD who had undergone coronary stenting, quantitative coronary angiography (QCA) were retrospectively studied. At the time of stent implantation and at 7 months post-stenting 675 patients had a follow-up angiography. Statistical analysis was made with the chi-square test for categorical variables, unpaired t test for continuous variables, univariate or multivariate regression for baseline and angiographic characteristics and the Kaplan-Meier method for rate of target lesion revascularization (TLR). Results Stent restenosis was defined as ≥50% diameter stenosis in the dilated segment. A total of 675 patients with 1074 lesions were subjected to angiographic follow-up for 7 months on average. Of these lesions, 448 were implanted with BMS whereas 626 lesions with DES. At 7 months, bare-metal in-stent restenosis occured in 148 lesions (33.0%), and bare metal in-segment restenosis in 155 lesions (34.6%) in contrast to drug-eluting in-stent restenosis in 48 lesions (7.7%) and drug-eluting in-segment restenosis in 73 lesions (11.7%) (P<0.001 compared with BMS respectively). Late loss in both in-stent and in segment was higher in BMS than in DES groups [(1.00±0.69) vs (0.28±0.52); (0.78±0.71) vs (0.21±0.52), P<0.001 respectively]. Angulated lesion, lesion length, pre-procedural minimal luminal diameter (MLD), and BMS were independent predictors for TLR, (P<0.01 respectively), whereas current smoker, ostial lesion, and stent overlapping, post-procedure in-stent MLD, lesion length, and stent types were independent predictors for in-segment restenosis (P<0.01 respectively). Standard coronary risk factors such as hypertension, hyperlipidemia, diabetes, and history of CAD were not associated with a higher rate of restenosis caused by BMS or DES implantation in our Chinese Han ethnic population. Conclusions Coronary stenting including BMS or DES implantation in Chinese Han ethnic patients is associated with a restenosis rate comparable to that demonstrated in previous studies from the western countries, and predictors of stent restenosis are somehow different from those in the western population. | XU Bo LI Jian-jun YANG Yue-jin MA Wei-hua CHEN Ji-lin QIAO Shu-bin QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2006 | Chinese Medical Journal2006，，7： | 23 |
| 2 | Angiographic prevalence of myocardial bridging in a defined very large number of Chinese patients with chest pain显示文摘背景:心肌内冠的动脉被称为的 epicardial 分割的肌纤维 overlying 心肌的衔接(MB ) 。MB 的可变流行与小、大的样品尺寸研究在尸体和 angiographic 系列被描述了。另外,没有类似的学习在中国人口被报导。这研究的目的是调查 MB 的 angiographic 流行在连续有从我们的中心的胸痛的 37,106 个中国病人。方法:我们进行了观察研究在经历的病人之中与 MB 评估连续案例选择冠的血管造影术,并且在很大的样品尺寸的这研究分析了 angiograhic 流行和 MB 的临床的特征。结果:在有胸痛的 37 105 个病人之中,我们以一种回顾的方式与 1011 MB 发现了 1002 个案例,并且全面流行是 2.70% 。尽管(991/1002 ) 超过 99% 病人有单个桥牌, 8 个案例被发现有超过二 MB (七与二,和一与三) 。没有动脉粥样硬化患者损害,总的来说 54.39% 案例(545/1002 ) 有 MB,并且(973/1011 )96.24% 在左前面的下降冠的动脉(男孩) 衔接定位了,主要在男孩的中间(792/1011, 78.33%) 。根据诺贝尔分类,单个桥(n=991 ) ,阻塞的 <50% 是占优势的(471/991, 47.52%) 。完全, 50%-69% 占了 34.81%(345/991 ) ,阻塞的 >70% 是 17.65%(175/991 ) 。结论:这些数据证明在有胸痛的中国病人的 angiographically 可检测的 MB 的流行类似于以前的研究的那些,与在这种很大的样品尺寸的 2.7% 流行。 | LI Jian-jun SHANG Zheng-lu YAO Min LI Jie YANG Yue-jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XU Bo XIA Ran GAO Run-lin | 2008 | Chinese Medical Journal2008，，5： | 17 |
| 3 | Role of plasma C-reactive protein in predicting in-stent restenosis in patients with stable angina after coronary stenting显示文摘背景血浆的角色高敏感在 in-stent 狭窄(ISR ) 的 C 反应的蛋白质(hs-CRP ) 仍然保持争论。我们在成功的冠的 stenting 以后与稳定的咽峡炎( SA )在病人在承认和后续调查了血浆 hs-CRP 水平以便为我们总结了的 ISR.Methods 澄清 hs-CRP 的预兆的价值有冠的 drug-eluting stent ( DES )的 303 个连续长期的 SA 病人 implantation.The ISR 被量的冠的分析分析( QCA )在一个平均数, 8 个月的后续,和病人作为 ISR 组( n=48 )和 non-ISR g 根据检测 ISR 被划分成二个组血浆 hs-CRP 在所有病人,在承认和 8 月的后续被检验在整个调查 period.Results QCA 继续的标准药介绍了那 48 个病人(15.8%) 在后续受不了 ISR。当血浆 hs-CRP 在在承认和后续的 non-ISR 组比那在 ISR 组是更高的时,基本临床的特征在二个组之间是类似的, P 0.001 分别地。 Multivariate 回归分析显示在承认或后续的那血浆 hs-CRP 水平能独立地预言 ISR 出现( OR=5.581 ,95% Cl 2.532-12.302 , P0.001and OR=6.299 ,95% CI 2.722-14.577 , P 0.001 ,分别地) .Conclusions 我们的数据显示那血浆 hs-CRP 水平可以独立地与冠的 DES 培植在 SA 病人在承认和后续预言 ISR ,它暗示长期的、持续全身的煽动性的回答可能涉及 ISR | XU Yan-lu LI Jian-jun XU Bo ZHU Cheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bin YUAN Jin-qing QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2011 | Chinese Medical Journal2011，，6： | 17 |
| 4 | Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting显示文摘背景尽管在预言动脉粥样硬化患者损害的快速的前进的 C 反应的蛋白质(CRP ) 的角色强烈地在不稳定的冠的动脉疾病被学习了,从有稳定的咽峡炎(SA ) 的病人的数据大部分是不在的。现在的学习评估了一个中间尺寸的耐心的队与 stent 培植和后续经历了经皮的冠的干预(一种总线标准)冠的 angiography ( CAG )并且测试了高度敏感的 CRP 的那增加的血浆水平将显示的假设 de novo 非目标的快速的前进在有 SA.Methods 的中国病人的冠的动脉损害学习人口与长期的 SA 311 个连续病人包括了在起始的承认上经历了冠的 stent | XU Yan-lu LI Jian-jun XU Bo ZHU Cheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bing YUAN Jin-qing QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2011 | Chinese Medical Journal2011，，19： | 17 |
| 5 | A comparison of clinical and angiographic outcomes after Excel bioabsorbable polymer versus Firebird durable polymer rapamycin-eluting stent for the treatment of coronary artery disease in a “real world” setting:six-month follow-up results显示文摘背景几临床的试用证明了 rapamycin-eluting stents 显著地在经皮的冠的干预(一种总线标准) 以后减少狭窄的风险。鲜艳的小鸟 stent 和 Excel stent (与 bioabsorbable 聚合物涂) rapamycin-eluting stents 的二种不同类型在中国被做,两个最近被州的食物药品管理局在中国为临床的使用同意了。然而,是否在在在2006年6月的每日的 practice.Methods 的 stents 的二种类型之间的安全和功效地有差别,是不清楚的, 190 个连续病人的一个总数专门与鲜艳的小鸟 stents 被对待( n=93 ,鲜艳的小鸟组)或胜过 stents ( n=97 ,胜过组)在我们的中心并且在这研究被包括。主要不利心脏的事件的频率(向,一死亡,心肌的梗塞或目标损害 revascularization 合成) ,二进制狭窄,和迟了的腔损失和 stent 血栓在二个 groups.Results 病人之间在一个六月的后续时期期间被比较,损害特征在这些组之间是可比较的。主要不利心脏的事件率在医院里并且在 6 个月是低的(2.1% 在 Excel 组织, 0% 在鲜艳的小鸟组织, P 0.05 ) 。6 月的 angiographic in-stent 狭窄率在两个组是 0% ,与联系迟了的损失(0.15 更高显著地在 PES 组织((0.14 ???????琠牨浯潢祬楳 吗?? | LIU Hai-bo XU Bo QIAO Shu-bin YANG Yue-jin MA Wei-hua QIN Xue-wen YAO Min WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran LI Jian-jun CHEN Ji-lin GAO Run-lin | 2007 | Chinese Medical Journal2007，，7： | 15 |
| 6 | Fatal complications in a patient with severe multi-space infections in the oral and maxillofacial head and neck regions: A case report显示文摘BACKGROUND Odontogenic infection is one of the common infectious diseases in oral and maxillofacial head and neck regions.Clinically,if early odontogenic infections such as acute periapical periodontitis,alveolar abscess,and pericoronitis of wisdom teeth are not treated timely,effectively and correctly,the infected tissue may spread up to the skull and brain,down to the thoracic cavity,abdominal cavity and other areas through the natural potential fascial space in the oral and maxillofacial head and neck.Severe multi-space infections are formed and can eventually lead to life-threatening complications(LTCs),such as intracranial infection,pleural effusion,empyema,sepsis and even death.CASE SUMMARY We report a rare case of death in a 41-year-old man with severe odontogenic multi-space infections in the oral and maxillofacial head and neck regions.One week before admission,due to pain in the right lower posterior teeth,the patient placed a cigarette butt dipped in the pesticide'Miehailin'into the'dental cavity'to relieve the pain.Within a week,the infection gradually spread bilaterally to the floor of the mouth,submandibular space,neck,chest,waist,back,temporal and other areas.The patient had difficulty breathing,swallowing and eating,and was transferred to our hospital as an emergency admission.Following admission,oral and maxillofacial surgeons immediately organized consultations with doctors in otolaryngology,thoracic surgery,general surgery,hematology,anesthesia and the intensive care unit to assist with treatment.The patient was treated with the highest level of antibiotics(vancomycin)and extensive abscess incision and drainage in the oral,maxillofacial,head and neck,chest and back regions.Unfortunately,the patient died of septic shock and multiple organ failure on the third day after admission.CONCLUSION Odontogenic infection can cause serious multi-space infections in the oral and maxillofacial head and neck regions,which can result in multiple LTCs.The management and treatment of LTCs such as multi-space infections should be multidisciplinary led by oral and maxillofacial surgeons. | Tian-Guo Dai Hong-Bing Ran Yin-Xiu Qiu Bo Xu Jin-Qiang Cheng Ying-Kai Liu | 2019 | World Journal of Clinical Cases2019，7，23： | 14 |
| 7 | Preparation of activated carbon from cattail and its application for dyes removal显示文摘Activated carbon was prepared from cattail by H3PO4 activation. The effects influencing the surface area of the resulting activated carbon followed the sequence of activated temperature > activated time > impregnation ratio > impregnation time. The optimum condition was found at an impregnation ratio of 2.5, an impregnation time of 9 hr, an activated temperature of 500°C, and an activated time of 80 min. The Brunauer-Emmett-Teller surface area and average pore size of the activated carbon were 1279 m2/g and 5.585 nm, respectively. A heterogeneous structure in terms of both size and shape was highly developed and widely distributed on the carbon surface. Some groups containing oxygen and phosphorus were formed, and the carboxyl group was the major oxygen-containing functional group. An isotherm equilibrium study was carried out to investigate the adsorption capacity of the activated carbon. The data fit the Langmuir isotherm equation, with maximum monolayer adsorption capacities of 192.30 mg/g for Neutral Red and 196.08 mg/g for Malachite Green. Dye-exhausted carbon could be regenerated effectively by thermal treatment. The results indicated that cattail-derived activated carbon was a promising adsorbent for the removal of cationic dyes from aqueous solutions. | Qianqian Shi Jian Zhang Chenglu Zhang Cong Li Bo Zhang Weiwei Hu Jingtao Xu Ran Zhao | 2010 | Journal of Environmental Sciences2010，22，1： | 13 |
| 8 | Drug-eluting stent for the treatment of small coronary lesion:comparison between sirolimus- and paclitaxel-eluting stent显示文摘有小冠的损害的背景病人在为在冠的 angioplasty 和 stenting 以后的重复干预的增加的风险。drug-eluting stents (DES ) 的功效被表明了改进这些病人的结果并且是兴趣的一个焦点。当前, DES 的二个平台是可得到的(sirolimus-eluting stent (SES ) 和 paclitaxel-eluting stent (足)) 。然而,它少些被知道了那 DES, SES 对足,为在这回顾的研究的小冠的 lesions.Methods 的治疗是优异的,有 151 损害的 87 个连续病人经历了冠的 SES (n=68 ) 和足(n=83 ) 的培植。量的冠的 angiography (QCA ) 在 8 月 post-stenting 在 stent 培植的时候并且随后被执行。小容器疾病在容器被定义为损害,直径 2.5 公里由 QCA 测量了。包括死亡,血栓,非致命的心肌的梗塞和目标损害 revascularization (TLR ) 的主要不利心脏的事件(向) 在二个 groups.Results 基线临床的特征之间被比较, angiographic 参数在二个组之间是类似的。在临床并且 angiographic 后续,全面血栓率在两个组是类似的(0 对 1.2% , P0.05 ) 。TLR 和在里面片断狭窄不是显著地不同的(19.1% 对 25.3% ;10.3% 对 10.8% , P=0.365 并且 P=0.913respectively ) 在二个组之间。然而, in-stent 狭窄率在 PES 组是显著地更高的(4.4% 对 21.7% ;P=0.002 ) 。同样,迟了的损失在 PES 组是显著地更高的((0.14 ???????琠牨浯潢祬楳 吗?? | LI Jian-jun XU Bo YANG Yue-Jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2007 | Chinese Medical Journal2007，，7： | 9 |
| 9 | Risks faced by donors of right lobe for living donor liver transplantation显示文摘BACKGROUND:Because of the shortage of deceased donors with livers fit for transplantation,living donor liver transplantation(LDLT)is becoming an attractive alternative.Attention should be paid to the donors,especially to those of the right lobe.In this study,we evaluated the risks faced by donors of the right lobe for adult-to-adult LDLT.METHODS:The perioperative data from 105 consecutive living donors of the right lobe performed in West China Hospital from January 2002 to December 2007 were retrospectively studied.Preoperative evaluation included CT,MRCP,and intraoperative cholangiography,showing liver volume,hepatic vasculature and the biliary system.The standard liver volume(SLV)and the ratio of left lobe volume to SLV were calculated.The right lobe grafts were obtained by transecting the liver on the right side of the middle hepatic vein without inflow vascular occlusion,using an ultrasonic dissector.After operation the donors were monitored in the Intensive Care Unit for about three days.Each donor was followed up for at least 6 months.RESULTS:There was no donor mortality.Major complications occurred in 14 donors(13.3%),of whom 3 received conservative treatment,8 required invasive paracentesis,and 3 required further surgery.All donors were recovered well and resumed their previous occupations.CONCLUSIONS:Donors of the right lobe face low risks.The preoperative evaluation,especially evaluation of the volume of the remnant liver,should be exact.During the operation,the patency of the remnant hepatic vasculature and bile duct must be preserved,and the extent of injury to the remnant liver should be limited as much as possible.The detection and treatment of postoperative complications should be diligently performed. | Ran, Shun Wen, Tian-Fu Yan, Lu-Nan Li, Bo Zeng, Yong Chen, Zhe-Yu Zhang, Yu Liao, Zhi-Xue Liang, Guan-Lin Li, Guo Zhang, Xian-Hua | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 10 | Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil显示文摘与化学疗法的药相结合的 Angiogenesis 禁止者在许多癌症的治疗有重要功效。金钱松属酸 B (PAB ) 是一个传统的终止怀孕的代理人,它以前被显示了减少肿瘤生长和 angiogenesis。在这研究,我们使用了高满意的屏蔽试金在人的脐的静脉 endothelial 房间(HUVEC ) 上检验 PAB 的效果。二个 hepatocarcinoma 22-transplanted 老鼠模型被用来与 5 氟尿嘧啶(5-Fu ) 在联合决定 PAB 功效。我们的结果建议没有明显的 cytotoxicity, PAB (0.1561.250 M ) 在 vitro 以一种集中依赖者方式禁止了 HUVEC 活动性。在 vivo, PAB (25 mg/kg/day ) 在联合治疗支持了 5-Fu (5 mg/kg/2 天) 的反肿瘤功效,导致显著地更高的肿瘤抑制率,更低的 microvessel 密度价值,和延长幸存时间。PAB 由在 G1/S 边界和 M 阶段堵住细胞周期行动了,这也被表明,脉管的 endothelial 生长因素的下面规定,组织缺氧可诱导的因素 1 并且 cdc2 的 cyclin E 表示,和起来规定表示。这些观察提供在有 5-Fu 的联合的 PAB 可能在癌症治疗是有用的第一条证据。 | Jingtao Liu Wei Guo Bo Xu Fuxiang Ran Mingming Chu HongzhengFu Jingrong Cui | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 6 |
| 11 | Reservoir Characteristics and Preservation Conditions of Longmaxi Shale in the Upper Yangtze Block, South China显示文摘The Upper Ordovician-Lower Silurian Longmaxi Shale in the Upper Yangtze block represents one of the most important shale gas plays in China. The shale composition,porosity,organic thermal maturity,and methane sorption were investigated at the Qilongcun section in the Dingshan area,southeastern Sichuan Basin. The results show that the Upper Ordovician-Lower Silurian Longmaxi Shale contains:(1) sapropelic I organic matter;(2) a 40-m thick bedded sequence where total organic carbon(TOC) content is > 2%;(3) a 30-m thick layer at the base of the Longmaxi Shale with a brittle mineral content higher than 50%; and(4) a mean methane adsorption capacity of 1.80 cm^3/g(7 MPa pressure). A positive correlation between TOC and sorbed gas indicates that organic matter content exerts an important control on methane storage capacity. Based on the analysis of the shale reservoir characteristics,the lower member of the Longmaxi Shale can thus be considered a favorable stratum for shale gas exploration and exploitation. It has similar reservoir characteristics with the Longmaxi Shale in the Jiaoshiba area tested with a high-yield industrial gas flow. However,based on tectonic analysis,differences in the level of industrial gas flow between the low-yield study area and the high-yield Jiaoshiba area may result from different tectonic preservation conditions. Evidence from these studies indicates the shale gas potential of the Longmaxi Shale is constrained by the reservoir and preservation conditions. | RAN Bo LIU Shugen Luba JANSA SUN Wei YANG Di WANG Shiyu YE Yuehao Christopher XIAO ZHANHG Jian ZHAI Cangbo LUO Chao ZHANG Changjun | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 6 |
| 12 | Advances in lung cancer screening and early detection显示文摘Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health worldwide.Two randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer screening.However,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation exposure.This review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related issues.Second,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is presented.Third,current explorations of strategies for suspected malignancy are summarized.Overall,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer. | Caichen Li Huiting Wang Yu Jiang Wenhai Fu Xiwen Liu Ran Zhong Bo Cheng Feng Zhu Yang Xiang Jianxing He Wenhua Liang | 2022 | Cancer Biology & Medicine2022，19，5： | 6 |
| 13 | USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity显示文摘Cyclic GMP-AMP synthase(cGAS)is an essential sensor of cytosolic DNA and critically mediates innate immune responses and autoimmunity.Modulating the activity and stability of cGAS provides potential strategies for treating viral or autoimmune diseases.Here,we report that ubiquitin-specific protease 29(USP29)deubiquitinates and stabilizes cGAS and promotes cellular antiviral responses and autoimmunity.Knockdown or knockout of USP29 severely impairs Herpes simplex virus 1(HSV-1)-or cytosolic DNA-induced expression of type I interferons(IFNs)and proinflammatory cytokines.Consistently,Usp29m/m mice produce decreased type I IFNs and proinflammatory cytokines after HSV-1 infection and are hypersensitive to HSV-1 infection compared to the wild-type littermates.In addition,genetic ablation of USP29 in Trex1−/−mice eliminated the detectable pathological and molecular autoimmune phenotypes.Mechanistically,USP29 constitutively interacts with cGAS,deconjugates K48-linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection.Reconstitution of cGAS into Usp29−/−cells fully rescues type I IFN induction and cellular antiviral responses after HSV-1 infection.Our findings thus reveal a critical role of USP29 in the innate antiviral responses against DNA viruses and autoimmune diseases and provide insight into the regulation of cGAS. | Qiang Zhang Zhen Tang Ran An Liya Ye Bo Zhong | 2020 | Cell Research2020，30，10： | 5 |
| 14 | A comparison of angiographic and clinical outcomes after sirolimus-eluting versus paclitaxel-eluting stents for the treatment of in-stent restenosis显示文摘背景 In-stent 狭窄(ISR ) 为 interventional 心脏病专家仍然是挑战。一些数据建议 drug-eluting stents (DES ) 与 ISR 为病人的治疗代表一种有希望的新选择。当前, 2 个 DES 平台是可得到的[sirolimus-eluting stents (SES ) 和 paclitaxel-eluting stents (足)] ,但是为对待 ISR 的任何一个途径的优势信服地没被表明。现在的学习的目的是回顾地与 ISR.Methods 在一系列连续病人在 ISR 的治疗以后把 angiographic 和临床的结果与 SES 或足作比较 745 个连续病人的一个总数在我们的中心从 2004 年 4 月 12 日与赤裸的金属 stents 被对待到 2004 年 12 月 31 日。这些,临床上驾驶目标损害 revascularization (TLR ) 在 7 个月从 54 个病人在 54 ISR 被执行。有 ISR 的 54 个病人, 36 收到了临床的结果的 SES 和 18 收到的 PES.Follow 起来包括的 angiography 和评价,在在那里的 DES implantation.Results 不是在在二之间的临床的数据(包括的药用法和损害特征) 组织的基线的重要差别以后,两个都执行了 7 个月。除了多重 stents 重叠,程序的参数在两个组也是类似的。七月的 angiographic 后续证明二进制狭窄率在在与 SES 对待的病人比那与足对待的病人是更高的(in-stent 二进制代码狭窄:27.8% 对 5.6% , P0.023;在里面片断二进制狭窄:44.4% 对 13.9% , P0.014 ) 。发生在住院期间或在后续经期期间的主要不利心脏的事件(向)包括血栓和 TLR 在两个组是类似的(22.2%对8.3%, P0.05 )从这种小样品尺寸的 .Conclusions 结果,回顾,单个中心的学习证明 SES 可能比在因为更低的7月的狭窄率( in-stent 和在里面片断二进制代码狭窄),没有向的增加的发生对待 ISR 的足优异。 | LI Jian-jun XU Bo YANG Yue-jin MA Wei-hua CHEN Ji-lin QIAO Shu-bing QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2006 | Chinese Medical Journal2006，，13： | 5 |
| 15 | P ill C am colon capsule endoscopy versus conventional colonoscopy for the detection of severity and extent of ulcerative colitis显示文摘 | Chen An Ye Yun Jie Gao Zhi Zheng Ge Jun Dai Xiao Bo Li Han Bing Xue Zhi Hua Ran Yun Jia Zhao | 2013 | Journal of Digestive Diseases2013，，3： | 4 |
| 16 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 17 | Factors influencing the natural regeneration of arrow bamboo in giant panda habitat of the north Minshan Mountains,southwestern China显示文摘To determine the effects of eco-factors on the regeneration of arrow bamboo in giant panda habitat,a field study was conducted in the Baozuo and Gonggangling Nature Reserves,Sichuan Province,China.A total of 183 quadrats(10 m×10 m) and 717 small quadrats(1 m×1 m) were investigated within the study site.Bamboo seedling density was used as an indicator of natural regeneration.Twelve factors were measured,which included topography and forest factors(elevation,slope aspect,slope degree,slope position,canopy cover,and shrub cover) and microhabitat factors(upper vegetation cover,herb cover,litter layer cover,moss cover,moss thickness,and dead bamboo density).A One-Way ANOVA was used to analyze the effects of topography and forest factors on seedling density,and a GLM(Generalized Linear Model) procedure was performed to examine the relationship between seedling density and microhabitat factors.The results indicated that elevation and canopy cover had highly significant effects on seedling density:bamboo seedling density was highest and showed the best regeneration at middle elevations(2800-3000 m) and under medium to medium-high canopy cover.Moss thickness,moss cover,and dead bamboo density were the most important microhabitat factors influencing the natural regeneration of bamboo:seedling density increased with increasing moss cover and moss thickness and decreased with increasing dead bamboo density.We propose that removal of dead bamboo and controlling grazing activities may accelerate the process of bamboo regeneration. | LI Bo ZHANG Man ZHONG Xue MOERMOND Timothy RAN JiangHong YANG XuYu | 2013 | Chinese Science Bulletin2013，58，17： | 4 |
| 18 | Application of imidacloprid controlled-release granules to enhance the utilization rate and control wheat aphid on winter wheat显示文摘During winter wheat production, aphids need to be controlled with pesticides for the entire growth period. Controlled-release technology has been regarded as an alternative method for the improvement of pesticide efficiency. This study investigated two types of imidacloprid controlled-release granule (CR-GR): 2% imidacloprid CR-GR and 0.2% imidacloprid pesticide-fertilizer controlled-release granule (PF-CR-GR) when wheat was sown in winter. The release performance, utilization rate, terminal residues in edible parts, control effect on aphids, and achieved winter wheat yield were evaluated for both laboratory experiments and field application. Imidacloprid PF-CR-GR released more quickly in aqueous medium than CR-GR because of its good water solubility. After CR-GR treatments, the concentrations in wheat roots and soil were similar throughout the entire sampling period, and the concentrations in shoots were about 10–20% of those in roots. Imidacloprid was better absorbed when CR-GR was used as root treatment, compared with foliar treatment. Field application showed that imidacloprid CR-GR and PF-CR-GR controlled aphids throughout the entire growth period of winter wheat and improved the wheat yield. These findings identified application of imidacloprid CR-GR and PF-CR-GR on winter wheat as an effective way to enhance the pesticide utilization rate and ensure adequate yield. This paper provides a theoretical basis for the scientific use of pesticides and guides scientific pesticide application. | YUAN Wan-ling XU Bo RAN Gang-chao CHEN Hui-ping ZHAO Peng-yue HUANG Qi-liang | 2020 | Journal of Integrative Agriculture2020，19，12： | 4 |
| 19 | Precast system and assembly connection of cement concrete slabs for road pavement: A review显示文摘Prefabricated pavement is increasingly applied worldwide due to the rapid construction on-site.This paper presents a state-of-the-art review of the precast systems and assembly connection of concrete slabs,as well as the precast pavement features.The previous research indicates that:(1)both super-slab and Michigan systems are recommended with the satisfied road performance close to the cast-in-place;(2)flexible base material is suggested for the fabricated pavement for the satisfied leveling and stress distribution;(3)to prevent the voiding phenomenon of the fabricated pavement,the sand cushion course,dry mixed mortar or self-leveling mortar,and other flowable materials could be used for the secondary leveling of the base after the pavement splicing;(4)two-direction dowel bars are recommended for slab connections of the fabricated pavement,which helps to improve the load transfer capacity of the joints and enhance the durability of the fabricated pavement structure;(5)the sealing treatment of precast slab joints needs strengthening to reduce the impact of surface runoff on the base course;(6)the further research focuses are designing with functional,composite,mechanized,intelligent,lightweight,and flexible pavement slabs.Besides,pavement mechanical properties induced by temperature overlapping traffic loads need to be revealed. | Mingjing Fang Ran Zhou Wenhui Ke Bo Tian Yubin Zhang Jianjun Liu | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，2： | 3 |
| 20 | Effect of integrated Traditional Chinese and Western Medicine on Gout显示文摘OBJECTIVE:To evaluate the curative effect of integrated Traditional Chinese and Western Medicine on gout,and to investigate the therapy timing and exact treatment options of integrated medicine.METHODS:Totally 860 patients were enrolled,including 460 patients with intermittent gout,200 patients with active Traditional Chinese Medicine(TCM)syndrome(TCM syndrome score≥6)and200 patients with stable TCM syndrome(score<6).They were randomly divided into intervention and control groups.The control group was treated according to Western Medicine guidelines.The intervention group was treated with integrated Traditional Chinese and Western Medicine.The efficacy of TCM syndrome,joint pain score,joint swelling score,ESR,C-reactive protein,serum uric acid,liver and kidney function,and the duration of remission of TCM syndrome were compared between the two groups before and after treatments.RESULTS:For the patients with stable TCM syndrome,there was no significant difference in the effective rate and inefficiency between the intervention group and the control group.For the active type,the effective rate of the intervention group is better than the control group significantly.For the stable type,there was no significant difference between the intervention group and the control group in improving the scores of joint pain and swelling,reducing the level of ESR,C-reactive protein,serum uric acid and improving liver and kidney function.For the active type,the differences between the two groups were significant.The stable stage of gout in the intervention group was longer than the control group.CONCLUSION:For the gout patients with stable TCM syndrome in the acute stage of gout,we can use TCM treatment or Western Medicine alternatively;for the patients with active TCM syndrome,the scheme of combination of Traditional Chinese and Western Medicine can be applied,with the better curative effect than any medicine alone. | LIU Wei WU Yuanhao XUE Bin JIN Yue ZHANG Shumin LI Peihao XIE Qing WANG Aihua GAO Jingyue CAI Yue ZHANG Bo LIU Xiaoya WANG Yi DUAN Ran | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 3 |
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