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| 1 | Marked elevation of B-type natriuretic peptide in patients with heart failure and preserved ejection fraction显示文摘Marked elevations of B-type natriuretic peptide(BNP)are not generally seen in patients with heart failure and preserved ejection fraction(HFpEF).The objective of this study was to examine the clinical and laboratory characteristics of a large cohort of patients with HFpEF and markedly elevated BNP.A retrospective examination of 421inpatients at a university hospital admitted with a diagnosis of HFpEF was performed.Clinical and echocardiographic data in 4 groups of patients with levels of BNP≤100 pg/mL,100-400 pg/mL,400-1,000 pg/mL and>1,000 pg/mL were compared.Patients with HFpEF and BNP>1,000 pg/mL(28%of the population)were characterized by impaired renal function and greater use of anti-hypertensive medications.A subset of these patients with BNP>1,000 pg/mL had normal renal function(21%)and were significantly older,more frequently female,and tended to have lower ejection fractions.Conversely,patients with HFpEF and BNP≤100 pg/mL were younger and had preserved renal function.BNP was inversely related to the likelihood of subsequent admission for heart failure,but not to myocardial infarction or death.In conclusion:BNP>1,000 pg/mL is seen in almost 1/3 of patients hospitalized with HFpEF.This elevation of BNP often reflects impaired renal function,but can also be seen in patients with preserved renal function but relatively impaired systolic function. | Samuel Tate Andrea Griem Blythe Durbin-Johnson Clifton Watt Saul Schaefer | 2014 | The Journal of Biomedical Research2014，28，4： | 7 |
| 2 | Blockade of K ATP Channels With Glibenclamide Does Not Abolish Preconditioning During Demand Ischemia显示文摘 | Steven D Correa Saul Schaefer | 1997 | The American Journal of Cardiology1997，，1： | 1 |
| 3 | ARC磷酸化是麻醉预处理抗细胞凋亡作用的关键因素显示文摘背景在心肌缺血一再灌注(ischemia/reperfusion,I/R)之前短暂暴露于挥发性麻醉剂中,被称为麻醉预处理,它可限制心肌损伤并抑制凋亡。半胱天冬酶募集域细胞凋亡抑制剂(apoptosisrepressorwithcaspaserecruitmentdomain,ARC)是一种可保护I/Rgf起的心肌凋亡的新型蛋白,可被磷酸化调控。因此我们假设麻醉预处理的抗凋亡作用可tt部分与ARC的磷酸化有关。方法实验中我们采用I/R的大鼠心脏模型进行七氟醚麻醉预处理。除了测定左室功能,也测定了给予和不给予麻醉预处理的ARC磷酸化水平。因为ARC的磷酸化状态是由钙神经素和蛋白激酶CK2所决定,所以通过钙神经素活性以及应用钙神经素抑制剂FK506和ARC磷酸化抑制剂4,5,6,7.四溴苯并三唑(TBB)来测定。结果无麻醉预处理的I/R组钙神经素增加,ARC磷酸化水平降低,而麻醉预处理可显著改善功能恢复、减少缺血损伤、限制钙神经素活性的增加、增加ARC磷酸化水平、减少细胞色素c释放以及阻止I/R后半胱天冬酶-8的增加。麻醉预处理的作用与FK506相似,可被TBB消除。结论本研究证实了一种麻醉预处理预防I/R后钙神经素增加的新途径,通过增加ARC的磷酸化水平减少凋亡标记物。 | Xiyuan Lu, MS Peter G. Moore, MD, PhD Hong Liu, MD Saul Schaefer, MD 毛祖旻(译) 李士通(校) | 2013 | 麻醉与镇痛2013，，6： | 0 |
| 4 | 短期禁食对离体鼠心缺血心肌功能的影响显示文摘目的:评估短期禁食是否影响缺血后离体鼠心的功能。方法:灌流进食组和禁食(24h)组离体鼠心。连续记录左心室发展压(LVDP)、舒张末期压(EDP)和心率(HR)。结果:与进食鼠相比,缺血后再灌期禁食鼠心显示EDP减低,LVDP增高。缺血诱发的心律失常发生率减少,禁食鼠(126.2±17.46)次/h,进食鼠(226.33±18.79)次/h,n=6,P<0.005。结论:短期禁食离体鼠心肌缺血后恢复更快、更好。 | 范书铎 Lifeng Wang Saul Schaefer 黄增艳 赵红艳 张璠 郭志宏 | 1998 | 中国医科大学学报1998，27，4： | 0 |
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