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| 1 | Collagen type Ⅲ is an important linking molecule between generated renal tubules and an artificial polyester interstitium--Reticulin as a linker between generated tubules and the interstitium显示文摘在再生医学领域,已经有很多人考虑在将来用干/祖细胞治疗急慢性肾功能衰竭。但是,要使这种治疗方案行之有效,需要了解关于患病肾脏肾小管发育的细胞生物学信息。与干/祖细胞治疗急慢性肾功能衰竭相关尚待明晰的细胞生物学问题包括:①干/祖细胞的整合。②干/祖细胞的定向分化类型。③新形成肾小管的空间构成。为了更好的了解这项技术的相关机制,文章应用了先进的培养技术在人工非细胞外基质材料界面条件下构建肾小管。将新生兔肾来源的干/祖细胞用多层聚酯纤维网覆盖,放置在灌注培养器中,用含1×10-7mol/L醛固酮的新鲜合成的在DMEM基础上改良的IMDM培养基诱导培养13d。扫描电镜下,在大豆凝集素、银染和抗Ⅲ型胶原或层粘连蛋白γ1单克隆抗体标记的全标本包埋爬片或冰冻切片上观察肾小管的生长情况。扫描电镜观察结果显示,新生成的肾小管完全被基底膜覆盖,纤维网状板有大量的纤维与生成的肾小管基底面和周围人工聚酯材料相互交联。抗Ⅲ型胶原染色和银染结果表明,在新生成的肾小管的基底膜和邻近的人工聚酯材料间有大量的纤维交织,在发育成熟的肾小管中有与新生成肾小管相同排列形式的Ⅲ型胶原纤维。以上实验结果说明,Ⅲ胶原是联系新生成的肾小管基底面和人工基质聚酯纤维的分子纽带。 | W.W. Minuth L. Denk A. Blattmann Ho Castrop | 2008 | 中国组织工程研究与临床康复2008，12，32： | 1 |
| 2 | The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization显示文摘 | P: droni E Bacher R Blattmann H | 1995 | Medical Physics1995，22，1： | 1 |
| 3 | The recognition pattern of sequential B cell epitopes of beta-lactoglobulin does not vary with the clinical manifestations of cow' s milk allergy显示文摘 | Heinzmann A Blattmann S Spuergin P | | 0，，04： | 1 |
| 4 | RNAi-based functional profiling of loci from blood lipid genome- wide association studies identifies genes with cholesterol- regulatory function显示文摘 | BLATTMANN P SCHUBERTH C PEPPERKOK R | 2013 | PLoS Genet2013，9，10： | 1 |
| 5 | Synergy of gene-mediated immunoprophylaxis and microbeam radiation therapy for advanced intracerebral rat 9L gliosarcomas显示文摘 | SMILOWITZ H M BLATTMANN H BRAUER-KRISCH E | 2006 | Journal of NeuroOncology2006，78，2： | 1 |
| 6 | Control of scionvigour by kiwifruit rootstocks is correlated with spring root pressure phenology显示文摘 | Clearwater M J Blattmann P Luo Z | 2007 | Journal of Experimental Botany2007，58，7： | 1 |
| 7 | The recgnition pattern of sequential B cell epitopes of β-lactoglobulin does not vary with the clinical manifestation of cow's milk allergy显示文摘 | Heizmann A Blattmann S Spuergin P | 1999 | Int Arch Allergy Immunol1999，，120： | 1 |
| 8 | Radiosensitization by histone deacetylase inhibition in an osteosarcoma mouse model显示文摘 | Blattmann C Thiemann M Stenzinger A | | 0，，11： | 1 |
| 9 | Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition显示文摘 | Blattmann C Oertel S Ehemann V | 2010 | Int J Radiat Oncol Bioi Phys2010，78，： | 1 |
| 10 | Optimal design of LCL harmonic filters for three-phase PFC rectifiers显示文摘 | Muhlethaler J Schweizer M Blattmann R | 2013 | IEEE Transactions on Power Electronics2013，28，7： | 1 |
| 11 | Enhancement of radiation response in osteosarcoma and rhabomyosarcoma cell lines by histone deacetylase inhibition显示文摘 | BLATTMANN C OERTEL S EHEMANN V | 2010 | Int J Radiat Oncol Biol Phys2010，78，1： | 1 |
| 12 | Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma 显示文摘 | Blattmann C Oertel S Schulz-Ertner D | 2010 | BMC Cancer2010，10，： | 1 |
| 13 | A novel tracking technique for the continuous precise measurement of tumour positions in confbrmal radiotherapy显示文摘 | Seller PG Blattmann H Kirsch S | 2000 | Phys Med Biol2000，45，9： | 1 |
| 14 | Combining magnetic and optical tracking for computer aided therapy显示文摘 | Muench RK Blattmann H Kaser-Hotz B | | 0，，： | 1 |
| 15 | The recgnition pattern of sequential B cell epitopes of β -lactoglobulin does not vary with the clinical manifestation of cow's milk allergy显示文摘 | HEIZMANN A BLATTMANN S SPUERGIN P | 1999 | Int Arch Allergy Immunol1999，120，： | 1 |
| 16 | Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition显示文摘 | Blattmann C Oertel S Ehemann V | | 0，，01： | 1 |
| 17 | Bench-scale evaluation of alternative biological treatment processes for the remediation of pentachlorophenol- and creosote-contaminated materials 显示文摘 | MUELLER J G LANTZ S E BLATTMANN B O | 1991 | Environ Sci Technol1991，25，6： | 1 |
| 18 | Vigor-controlling rootstocks affect early shoot growth and leaf ar?ea development of kiwifruit显示文摘 | CLEARWATER M J SELEZNYOVA A N THORP T G BLATTMANN P BARNETT A M LOWE R G AUSTTIN P T | 2006 | Tree Physiology2006，26，： | 1 |
| 19 | The 200-MeV proton therapy project at the Paul Scherrer Institute: Conceptual design and practical realization 显示文摘 | Pedroni E Bacher R Blattmann H | 1995 | Medical Physics1995，22，1： | 1 |
| 20 | Control of scion vigour by kiwifruit rootstocks is correlated with spring root pressure phenology显示文摘 | CLEARWATER M J BLATTMANN P LUO Z LOWE R G | 2007 | Journal of Experimental Bota?ny2007，58，7： | 1 |
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