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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | Fatty liver disease in severe obese patients:Diagnostic value of abdominal ultrasound显示文摘AIM:To evaluate the sensitivity and specificity of abdominal ultrasound (US) for the diagnosis of hepatic steatosis in severe obese subjects and its relation to histological grade of steatosis. METHODS: A consecutive series of obese patients, who underwent bariatric surgery from October 2004 to May 2005, was selected. Ultrasonography was performed in all patients as part of routine preoperative time and an intraoperative wedge biopsy was obtained at the beginning of the bariatric surgery. The US and histological findings of steatosis were compared, considering histology as the gold standard. RESULTS: The study included 105 patients. The mean age was 37.2 ± 10.6 years and 75.2% were female. The histological prevalence of steatosis was 89.5%. The sensitivity and specificity of US in the diagnosis of hepatic steatosis were, respectively, 64.9% (95% CI: 54.9-74.3) and 90.9% (95% CI: 57.1-99.5). The positive predictive value and negative predictive value were, respectively, 98.4% (95% CI: 90.2-99.9) and 23.3% (95% CI: 12.3-39.0). The presence of steatosis onUS was associated to advanced grades of steatosis on histology (P = 0.016). CONCLUSION: Preoperative abdominal US in our series has not shown to be an accurate method for the diagnosis of hepatic steatosis in severe obese patients. Until another non-invasive method demonstrates better sensitivity and specificity values, histological evaluation may be recommended to these patients undergoing bariatric surgery. | Alessandro de Moura Almeida Helma Pinchemel Cotrim Daniel Batista Valente Barbosa Luciana Gordilho Matteoni de Athayde Adimeia Souza Santos Almir Galvo Vieira Bitencourt Luiz Antonio Rodrigues de Freitas Adriano Rios Erivaldo Alves | 2008 | World Journal of Gastroenterology2008，14，9： | 10 |
| 3 | Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents显示文摘AIM:To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease(NAFLD) among asymptomatic Brazilian adolescents. METHODS:Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia,northeastern Brazil.The children answered a questionnaire that included age,gender,race,and medical history,and were submitted to a complete physical exam and abdominal ultrasound.Biochemical exams included:ALT,AST,GGT,C reactive protein(CRP),fasting glucose,insulin,cholesterol and triglycerides.Criteria for NAFLD included:the presence of steatosis in ultrasound and/or high level of ALT,negative or occasional historic of intake of alcohol(≤140 g/wk),negative investigation for hepatitis A,B,C,auto-immune hepatitis,Wilson disease and hemochromatosis.RESULTS:From October,2005 to October,2006,the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7±2.0 years.One hundred ninety-nine had central obesity.The prevalence of NAFLD was 2.3%,most of whom were male and white.Insulin resistance(IR)was observed in 22.9% of them and had positive correlations with ALT and GGT(P<0.05).Elevated CRP was observed in 6.9% of the cases;however,it was not associated with WC,IR or liver enzymes. CONCLUSION:The prevalence of NAFLD in Brazilian adolescents was low.The ethnicity may have influence this frequency in the population studied,which had a large proportion of African descendents. | Raquel Rocha Helma Pinchemel Cotrim Almir Galvo Vieira Bitencourt Daniel Batista Valente Barbosa Adméia Souza Santos Alessandro de Moura Almeida Bruno Cunha Isabel Guimares | 2009 | World Journal of Gastroenterology2009，15，4： | 2 |
| 4 | Role of diet and nutrition in inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs)are closely linked to nutrition.The latest research indicates that diet and nutrition are significantly involved in the etiopathogenesis of the disease,although their specific role throughout its clinical course still remains unclear.This study reviewed how diet and nutrition are associated with IBD development and management.Even though specific diets have been shown to bring about positive outcomes,there is currently no scientific consensus regarding an appropriate diet that would benefit all IBD patients.We suggest that individualized dietary recommendations are of the greatest importance and that diets should be planned to provide individual IBD patients with specific nutrient requirements while keeping all the clinical aspects of the patients in mind.Further research is clearly necessary to investigate nutritional factors involved in IBD development and,especially,to evaluate the applications of the diets during the course of the disease. | Marina Moreira de Castro Lívia Bitencourt Pascoal Karine Mariane Steigleder Beatriz Piatezzi Siqueira Ligiana Pires Corona Maria de Lourdes Setsuko Ayrizono Marciane Milanski Raquel Franco Leal | 2021 | World Journal of Experimental Medicine2021，11，1： | 2 |
| 5 | Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures显示文摘Background: Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments: control, which received no supplement; supplementation for the last 30 d of gestation(30-d; 3.0 kg/d); supplementation for the last 60 d of gestation(60-d; 1.5 kg/d); or supplementation for the last 90 d of gestation(90-d; 1.0 kg/d). All supplemented treatments received the same total amount of supplement throughout the experiment: 90 kg(20% of crude protein). A second experiment(Experiment 2) was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d each.Results: There was a linear effect of the number of days of supplementation on calving body weight(BW; P < 0.05)and a quadratic effect on BW change from parturition to d 31 post-calving(P < 0.05), with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW(P > 0.10). A significant linear effect on interval from parturition to conception(P < 0.05) was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility(P > 0.10). Nitrogen excreted through urine tended to increase linearly with the level of supplementation(P < 0.10).Conclusion: Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of days from calving to re-conception in the following breeding season compared to the usually recommended period of supplementation of 90 d pre-partum. | Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique Jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega Victor Valério de Carvalho Josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro Jéssika Almeida Bitencourt | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 2 |
| 6 | Protective effects of Syzygium cumini seed extract against methylmercury induced sistemic toxicity in neonatal rats显示文摘 | ABDALLA F H BELLE L P BITENCOURT P E R | 2011 | Biometals2011，24，2： | 1 |
| 7 | Nonalcoholic fatty liver disease:clinical and histological characteristics in obese who underwent bariatric surgery显示文摘 | Bitencourt AG Cotrim HP Alves E | 2007 | Acta Gastroenterol Latinoam2007，37，4： | 1 |
| 8 | Butyrylcholinesterase and γ-glutamyl transferase activities and oxidative stress markers are altered in metabolic syndrome, but are not affected by body mass index显示文摘 | De Bona KS Bonfanti G Bitencourt PE | 2013 | Inflammation2013，36，6： | 1 |
| 9 | Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervivornis 显示文摘 | Bitencourt F S Figueiredo J G Mota M R L | 2008 | Naunyn-Schmied Arch Pharmacol2008，377，2： | 1 |
| 10 | Anti- inflammatory and antipyretic effects of Sonehus oleraeeus in rats显示文摘 | Vilela FC Bitencourt AD Cabral LD Franqui LS Soncini R Gi usti-Paiva A | 2010 | Journal of Ethnopharmaeol2010，127，3： | 1 |
| 11 | Hyaluronidase recruits mesenehymal-like cells to the lung and ameliorates fibrosis 显示文摘 | Bitencourt CS Pereira PA Ramos SG | | Fi- brogenesis Tissue Repair0，4，： | 1 |
| 12 | Presence of blaOXA-48-carrying IncF plasmid in an Escherichia fergusonii strain isolated from a sugarcane soil显示文摘Dear Editor,A large number of antimicrobial agents used for the treatment of humans and animals reach water sources and agricultural soils in different ways,including animal excreta.Therefore,antimicrobial-resistant bacteria,carrying important antimicrobial resistance genes(ARGs),circulate between humans,animals,and the environment,giving attention to the concept of One Health(Topp,2017;Tiedje et al.,2019). | Jessica Aparecida Silva MORETTO Joao Pedro Rueda FURLAN Vania Santos BRAZ Tamires Aparecida BITENCOURT Eliana Guedes STEHLING | 2020 | Pedosphere2020，30，2： | 1 |
| 13 | Aque-ous and methanolic extracts of Caulerpa mexicanasuppress cell migration and ear edema induced by in-flammatory agents 显示文摘 | Bitencourt MA Dantas GR Lira DP | 2011 | Mar Drugs2011，9，8： | 1 |
| 14 | Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients显示文摘 | Nabhan SK Bitencourt MA Duval M | 2010 | Haematologica2010，95，10： | 1 |
| 15 | Thymoma originating in a giant thymolipoma: a rare intrathoracic lesion显示文摘 | Guimaraes MD Benveniste MF Bitencourt AG | 2013 | Ann Thorac Surg2013，96，3： | 1 |
| 16 | Correlation between PET/CT results and histological and immunohistochemical find- ings in breast carcinomas显示文摘 | Bitencourt A G Lima E N Chojniak R | 2014 | Radiol Bras2014，47，2： | 1 |
| 17 | Comparative study ofIgA nephropathy with and without crescents显示文摘 | Bitencourt DC Bahiense OM Saldanha LB | 2004 | Braz J Med Biol Res2004，37，9： | 1 |
| 18 | An in vitro comparison of a new vinyl chalcogenide and sodium selenate on adenosine deaminase activity of human leukocytes 显示文摘 | Belle LP Bitencourt PE Abdalla FH | 2011 | Chem Biolo Interact2011，189，3： | 1 |
| 19 | Syzygium jambos and Solanum guaraniticum Show Similar Antioxidant Properties but Induce Different Enzymatic Activities in the Brain of Rats显示文摘 | Bonfanti G Bitencourt PR Bona KS | | 0，，08： | 1 |
| 20 | Fructose-I, 6-bisphosphate induces phenotypic reversion of activated hepatic stellate cell显示文摘 | de Mesquita FC Bitencourt S Caberlon E | 2013 | Eur J Pharmaeol2013，720，13： | 1 |
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