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| 1 | Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies显示文摘Homodimeric prodrug-based self-assembled nanoparticles,with carrier-free structure and ultrahigh drug loading,is drawing more and more attentions.Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage.The influence of the linkages on the self-assembly,in vivo fate and antitumor activity of homodimeric prodrugs is the focus of research.Herein,three docetaxel(DTX)homodimeric prodrugs are developed using different lengths of diselenide bond-containing linkages.Interestingly,compared with the other two linkages,the longest diselenide bond-containing linkage could facilitate the self-delivery of DTX prodrugs,thus improving the stability,circulation time and tumor targeting of prodrug nanoassemblies.Besides,the extension of linkages reduces the redox-triggered drug release and cytotoxicity of prodrug nanoassemblies in tumor cells.Although the longest diselenide bond-containing prodrug nanoassemblies possessed the lowest cytotoxicity to 4T1 cells,their stable nanostructure maintained intact during circulation and achieve the maximum accumulation of DTX in tumor cells,which finally“turned the table”.Our study illustrates the crucial role of linkages in homodimeric prodrugs,and gives valuable proposal for the development of advanced nano-DDS for cancer treatment. | Lingxiao Li Shiyi Zuo Fudan Dong Tian Liu Yanlin Gao Yinxian Yang Xin Wang Jin Sun Bingjun Sun Zhonggui He | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 3 |
| 2 | Influence of anchorage length and pretension on the working resistance of rock bolt based on its tensile characteristics显示文摘In coal mining roadway support design,the working resistance of the rock bolt is the key factor affecting its maximum support load.Effective improvement of the working resistance is of great significance to roadway support.Based on the rock bolt’s tensile characteristics and the mining roadway surrounding rock deformation,a mechanical model for calculating the working resistance of the rock bolt was established and solved.Taking the mining roadway of the 17102(3)working face at the Panji No.3 Coal Mine of China as a research site,with a quadrilateral section roadway,the influence of pretension and anchorage length on the working resistance of high-strength and ordinary rock bolts in the middle and corner of the roadway is studied.The results show that when the bolt is in the elastic stage,increasing the pretension and anchorage length can effectively improve the working resistance.When the bolt is in the yield and strain-strengthening stages,increasing the pretension and anchorage length cannot effectively improve the working resistance.The influence of pretension and anchorage length on the ordinary and high-strength bolts is similar.The ordinary bolt’s working resistance is approximately 25 kN less than that of the high-strength bolt.When pretension and anchorage length are considered separately,the best pretensions of the high-strength bolt in the middle of the roadway side and the roadway corner are 41.55 and 104.26 kN,respectively,and the best anchorage lengths are 1.54 and 2.12 m,respectively.The best anchorage length of the ordinary bolt is the same as that of the high-strength bolt,and the best pretension for the ordinary bolt in the middle of the roadway side and at the roadway corner is 33.51 and 85.12 kN,respectively.The research results can provide a theoretical basis for supporting the design of quadrilateral mining roadways. | Jucai Chang Kai He Dongdong Pang Dong Li Chuanming Li Bingjun Sun | 2021 | International Journal of Coal Science & Technology2021，8，6： | 2 |
| 3 | Minor change in the length of carbon chain has a great influence on the antitumor effect of paclitaxel-fatty alcohol prodrug nanoassemblies:Small roles,big impacts显示文摘Prodrug-based nanoassembly emerges as a hopeful way for the efficient delivery of antitumor drugs,with carrier-free structure and ultra-high drug loading.Carbon chains are widely used to design self-assembling prodrugs.The impacts of the length of carbon chains on the self-assembly stability,drug delivery efficiency and antitumor effect of prodrugs have not been fully elucidated.Here,three paclitaxel prodrugs were synthesized by conjugating paclitaxel with octanol(C_(8)),decanol(C_(10))or dodecanol(C_(12))through disulfide bond.The three prodrugs could form homogeneous nanoparticles,with over 50%drug loading and redox dual-responsivity.Interestingly,the length extension of carbon chains ameliorates the self-assembly and the colloidal stability of prodrugs,thus improving the drug delivery efficiency.The optimal paclitaxel-dodecanol prodrug nanoassemblies exhibit better antitumor efficacy than Taxol and Abraxane.These findings are meaningful for the rational design of advanced nanomedicines in cancer therapy. | Xin Wang Lingxiao Li Danping Wang Shiyi Zuo Tian Liu Fudan Dong Xuanbo Zhang Zhonggui He Bingjun Sun Jin Sun | 2022 | Nano Research2022，15，4： | 1 |
| 4 | Towards a deeper understanding of the formation of friction-induced hillocks on monocrystalline silicon显示文摘 | YU Bingjun LI Xiaoying DONG Hanshan | 2012 | Joumal ofPhysicsD: Applied Physics2012，45，14： | 1 |
| 5 | Direct Spectrophotometric Determination of Trace Cadmium(II) in Food Samples with 2-Acetylmercaptophenyldiazoaminoazobenzene (AMPDAA)显示文摘 | Yongwen Liu Dong Yang Xijun Chang Yong Guo Bingjun Din Shuangming Meng | 2004 | Microchimica Acta2004，，4： | 1 |
| 6 | Mitogenomic Conservation Genetics of the Critically Endangered Liaoning Clawed Salamander显示文摘The Liaoning clawed salamander(Onychodactylus zhaoermii)is an endemic and critically endangered amphibian species of China.To study the population genetics of natural populations of this species,32 samples were collected from six different locations,and the mitochondrial genome was sequenced.Population genetic analyses showed that the Liaoning clawed salamander is composed of only one radialized cluster with ultralow nucleotide diversity.Late Pleistocene climate cooling(-100 to-30 kya)may have reduced the effective population size of the Liaoning clawed salamander,and the subsequent temperature increase(~25 kya to present)provided the opportunity for population expansion.Because of heat sensitivity,the maximum temperature of the prebreeding period,especially from March to May,is very important for the surface environment living in the Liaoning clawed salamander.Three suitable regions were predicted by the MaxEnt model,and the largest suitable region(approximately 899 km2)was at the four-county boundary area and was larger than the present’Natural Conservation Community of the Liaoning Clawed Salamander’.To ensure more effective protection of all Liaoning clawed salamanders,we suggest extending the current’Natural Conservation Community of the Liaoning Clawed Salamander’to include the four-county boundary area. | Yu ZHOU Boyang YU Jichuan ZHAO Fang WANG Zhenwei WANG Bingjun DONG Baotian YANG | 2021 | Asian Herpetological Research2021，12，4： | 1 |
| 7 | Spatial heterogeneity and compositional profiles of dissolved organic matter in farmland soils across China' Mainland显示文摘Dissolved organic matter(DOM) plays an essential role in many geochemical processes,however its complexity, chemical diversity, and molecular composition are poorly understood. Soil samples were collected from 500 vegetable fields in administrative regions of China' Mainland, of which 122 were selected for further investigation. DOM properties were characterized by three-dimensional excitation-emission matrix(3D-EEM) fuorescence spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry(FTICRMS)(field intensity is 15 Tesla). Our results indicated that the main constituents were UVA humic-like substances, humic-like substances, fulvic acid-like substances, and tyrosine-like substances. A total of 10,989 molecular formulae with a mass range of 100.04 to 799.59 Da were detected, covering the mass spectrometric information of the soil samples from 27 different regions. CHO and CHON molecules were dominant in DOM, whereas lignin, tannins,and aromatic substances served as the main components. The results of cluster analysis revealed that the soil properties in Jiangxi Province were considerably different from those in other regions. The key backgrounds of the DOM molecular characteristics in the vegetablefield soil samples across China' Mainland were provided at the molecular level, with large abundance and great variability. | Bingjun Han Liyuan Chen Kang Xiao Yang Liu Dong Cao Lu Yu Yujun Li Shu Tao Wenxin Liu | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 8 | Enhancement of red emission assigned to inversion defects in ZnAl2O4:Cr3+ hollow spheres显示文摘ZnAl2O4:Cr3+hollow spheres composed of secondary nanoparticles with single spinel phase were fabricated using carbon templets.Monitoring the emission of 687 nm,two wide excitation bands attributed to the electrons of Cr3+transiting from 4A2g(4F)→4T1g(4F)and 4A2g(4F)→4T2g(4F)were observed.The broad excitation band at about 397 nm was asymmetric and consisted of two peaks,indicating that there was a trigonal distortion existing in the lattices.The intensity of all emitting peaks revealed sharp increasing trend with the sintering temperature increase,and the intensity of emission at 698 nm assigned to inversion defects was more intense than that of emission at 687 nm assigned to octahedral Cr3+ions in the undistorted spinel lattice.The samples with higher synthesized temperature revealed longer decay time,and the relative weightage of shorter decay time component decreased with the increase of sintering temperature,indicating that the surface defects decreased. | Dong Zhang Jingxin Chen Chunyu Du Bingjun Zhu Qingru Wang Qiang Shi Shouxin Cui Wenjun Wang | 2020 | Frontiers of Materials Science2020，14，1： | 0 |
| 9 | Assessing microbial and chemical exposure risks of Giardia in indoor swimming pool water disinfected by chlorine显示文摘Swimming pools adopt chlorination to ensure microbial safety. Giardia has attracted attention in swimming pool water because of its occurrence, pathogenicity, and chlorine resistance. To control Giardia concentrations in pool water and reduce the microbial risk, higher chlorine doses are required during disinfection. Unfortunately, this process produces carcinogenic disinfection byproducts that increase the risk of chemical exposure. Therefore, quantitatively evaluating the comparative microbial vs. chemical exposure risks that stem from chlorination inactivation of Giardia in swimming pool water is an issue that demands attention. We simulated an indoor swimming pool disinfection scenario that followed common real-world disinfection practices. A quantitative microbial risk assessment coupled with a chemical exposure risk assessment was employed to compare the Giardia microbial exposure risk(MER) and the trihalomethane chemical exposure risk(CER) to humans. The results demonstrated a 22% decrease in MER-and CER-induced health exposure risk, from 8.45E-5 at 8:00 to 6.60E-5 at 19:00. Both the MER and CER decreased gradually, dropping to 3.26E-5 and 3.35E-5 at 19:00, respectively. However, the CER exceeded the MER after 18:30 and became the dominant factor affecting the total exposure risk. Past the 18 hr mark, the contribution of trihalomethane CER far exceeded the risk aversion from microbial inactivation, leading to a net increase in total exposure risk despite the declining MER. Swimmers may consider swimming after 19:00, when the total exposure risk is the lowest. Lowering water temperature and/or p H were identified as the most sensitive factors to minimize the overall health exposure risk. | Chenyue Yin Bingjun Liu Kyu Hur Shengkun Dong | 2022 | Journal of Environmental Sciences2022，34，7： | 0 |
| 10 | Synergetic lethal energy depletion initiated by cancer cell membrane camouflaged nano-inhibitor for cancer therapy显示文摘Mitochondrial bioenergy plays a vital role in the occurrence and development of cancer.Although strategies to impede mitochondrial energy supply have been rapidly developed,the anticancer efficacy is still far from satisfactory,mainly attributed to the hybrid metabolic pathways of mitochondrial oxidative phosphorylation(OXPHOS)and glycolysis.Herein,we construct a cancer cell membrane camouflaged nano-inhibitor,mTPPa-Sy nanoparticle(NP),which co-encapsulates OXPHOS inhibitor(mitochondrial-targeting photosensitizers:TPPa)and glycolysis inhibitor(syrosingopine(Sy))for synergistically blocking the two different energy pathways.The mTPPa-Sy NPs exhibit precision tumor-targeting due to the high affinity between the biomimic membrane and the homotypic cancer cells.Under laser irradiation,the mitochondrial-targeting TPPa,which is synthesized by conjugating pyropheophorbide a(PPa)with triphenylphosphin,produces excessive reactive oxygen species(ROS)and further disrupts the OXPHOS.Interestingly,OXPHOS inhibition reduces O_(2) consumption and improves ROS production,further constructing a closed-loop OXPHOS inhibition system.Moreover,TPPa-initiated OXPHOS inhibition in combination with the Sytriggered glycolysis inhibition results in lethal energy depletion,significantly suppressing tumor growth even after a single treatment.Our findings highlight the necessity and effectiveness of synergetic lethal energy depletion,providing a prospective strategy for efficient cancer therapy. | Fudan Dong Qikun Jiang Lingxiao Li Tian Liu Shiyi Zuo Lin Gao Mengna Fang Yanlin Gao Bingjun Sun Cong Luo Zhonggui He Jin Sun | 2022 | Nano Research2022，15，4： | 0 |
| 11 | Testing Hypotheses of Pleistocene Population History Using Coalescent Simulations: Refugial Isolation and Secondary Contact in Pseudepidalea raddei (Amphibia: Bufonidae)显示文摘The impact of the Quaternary glaciation on eastern China's local fauna and flora is a topic of considerable interest. We use mitochondrial DNA(mtDNA) sequences and coalescent simulations to test two general biogeographic hypotheses related to the effect of the Pleistocene climatic fluctuations on a widespread, eastern Chinese amphibian, Pseudepidalea raddei. Genealogical reconstructions are made and they detect major western and eastern lineages, which overlap in northwestern China, and possibly indicate the secondary contact of the populations that had entered the region from separate glacial refugia. Coalescent tests rejected alternative hypotheses of fragmentation of either a widespread ancestor or panmixia. The tests instead supported the hypothesis of geographic isolation and a remarkable dispersal pattern in one of the lineages. Though the Pleistocene climatic events are known to have affected the historical distributions and intra-specific divergence of Chinese squamates, coalescent and non-coalescent demographic analyses indicated that the toad P. raddei was not adversely affected by glacial cycling. Presumably, an increase in the amount of climatically mild habitats in East Asia is due to the development of monsoons since the Mid-late Pleistocene is responsible for the relatively mild effects. | Bingjun DONG Jing CHE Li DING Song HUANG Robert W.MURPHY Ermi ZHAO Yaping ZHANG | 2012 | Asian Herpetological Research2012，3，2： | 0 |
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