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| 1 | How to treat an extensive form of primary intestinal lymphangiectasia?显示文摘We report a case of a 42-year-old man with a rare disorder known as primary intestinal lymphangiectasia,which is characterized by dilated intestinal lymphatics that lead to the development of protein-losing enteropathy. The patient presented with a grand mal seizure caused by malabsorption-derived electrolytes and a protein disorder. Signs of the disease, including chronic diarrhea and peripheral edema, manifested10 years ago, but a diagnosis was never made. The diagnosis was suspected because of the clinical manifestations, laboratory tests, imaging and endoscopic findings. Hyperemic and edematous mucosa of the small intestine corresponded to scattered white spots with dilated intestinal lymphatics and whitish villi in the histological specimen of the biopsied jejunal mucosa.Although numerous therapeutic strategies are available,only octreotide therapy proved to be an effective means of therapeutic resolution in this patient. Although the patient had a partial remission following the use of a slow release formula of octreotide, his prognosis, clinical course, and future treatment challenges are yet to be determined. | Rosana Troskot Dragan Jurcic Ante Bilic Marija Gomercic Palcic Stanko Tezak Ivana Brajkovic | 2015 | World Journal of Gastroenterology2015，21，23： | 6 |
| 2 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 3 | Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options:An Update显示文摘morbidity and mortality for healthcare systems worldwide.It imparts an enormous economic burden to societies,making continuous research and informational updates about its pathogenesis and treatment crucial.This review′s focus is on the current knowledge about the Wnt signaling path-way,serving as an important pathway in liver fibrosis development and activation of hepatic stellate cells(HSCs).Two types of Wnt pathways are distinguished,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent pathway.The dynamic balance of physiologically healthy liver and hepatocytes is disturbed by repeated liver injuries.Activation of theß-catenin Wnt pathway prevents the regeneration of hepatocytes by the replacement of extracellular matrix(ECM),leading to the appearance of scar tissue and the formation of regenerated nodular hepatocytes,lacking the original function of healthy hepatocytes.Therefore,liver function is reduced due to the severely advanced disease.Selective inhibition ofß-catenin inhibits inflammatory processes(since chemokines and pro-inflammatory cytokines are produced during Wnt activation),reduces growth of activated HSCs and reduces collagen synthesis and angiogenesis,thereby reducing the progression of liver fibrosis in vivo.While the canonical Wnt pathway is usually inactive in a physiologically healthy liver,it shows activity during cell regeneration or renewal and in certain pathophysiological conditions,such as liver diseases and cancer.Targeted blocking of some of the basic components of the Wnt path-way is a therapeutic approach.These include the frizzled transmembrane receptor(Fz)receptors using the secreted frizzled-related protein family(sFRP),Fz-coreceptors low-density LRP 5/6 through dickkopf-related protein 1(DKK1)or niclosamide,glycogen kinase-3 beta(GSK-3β)using SB-216763,cyclic-AMP response element-binding protein(CBP)using PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-specific transcription factor(TCF)system as well as Wnt inhibitory factor 1(WIF1)and miR-17-5p using pinostilbene hydrate(PSH).Significant progress has been made in inhibiting Wnt and thus stopping the progression of liver fibrosis by diminishing key components for its action.Comprehending the role of the Wnt signaling pathway in liver fibrosis may lead to discovery of novel targets in liver fibrosis therapeutic strategies’development. | Kristina Duspara Kristina Bojanic Josipa Ivanusic Pejic Lucija Kuna Tea Omanovic Kolaric Vjera Nincevic Robert Smolic Aleksandar Vcev Marija Glasnovic Ines Bilic Curcic Martina Smolic | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 4 | Comparative characterization of cultured human term amnion epithelial and mesenchymal stromal cells for application in cell therapy 显示文摘 | Bilic G Zeisberger S M Mallik A S | 2008 | Cell Transplant2008，17，8： | 1 |
| 5 | Renal tubular epithelial expression of the costimulatory molecule B7RP-1 (inducible costimulator ligand)显示文摘 | Schoop R Bilic G | 2002 | J Am Soc Nephrol2002，13，6： | 1 |
| 6 | Renal tubular epithelial expression of the costimulatory molecule B7RP-1(inducible costimulator ligand)显示文摘 | Schoop R Bilic G Neuweiler J Le Hir M Yoshinaga SK | 2002 | J Am Soc Nephro2002，13，6： | 1 |
| 7 | Computer-assisted preoperative planning (CAPP) in orthopaedic surgery 显示文摘 | Zdravkovic V Bilic R | 1990 | Comput Methods Programs Biomed1990，32，2： | 1 |
| 8 | In vitro lesion repair by human amnion epithelial and mesenehymal cells显示文摘 | BILIC G OCHSENBEIN-KOLBLE N HALL H | 2004 | Am J Obstet and Gyneeol2004，190，1： | 1 |
| 9 | Risk factors and outcome di- fferences between ischemic and hemorrhagic stroke显示文摘 | Bilic I Dzamonja G Lusic I | 2009 | Acta Clin Croat2009，48，4： | 1 |
| 10 | Clinical course of uremic neuropathy in long@ term hemodialysis显示文摘 | D Jurcic A Bilic D Schwarz | | 0，，： | 1 |
| 11 | Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation显示文摘 | Bilic J Huang YL Davidson G | | 0，，5831： | 1 |
| 12 | Sequence analysis and comparison of avian hepatitis E viruses from Australia and Europe indicate the existence of different genotypes显示文摘 | Bilic I Jaskulska B Basic A | 2009 | J Gen Virol2009，90，： | 1 |
| 13 | Clinical course of uremicneuropathy in long-term hemodialysis显示文摘 | Jurcic D Bilic A Schwarz D | 2008 | Coll Antropol2008，32，3： | 1 |
| 14 | Renal tubular epithelial expression of the costimulatory molecule B7 RP-1 ( inducible costimulator ligand) 显示文摘 | Wahl P Schoop R Bilic G | 2002 | J Am Soc Nephrol2002，13，6： | 1 |
| 15 | Conservative treatment of extra-articular Colles' type fractures of the distal radius : prospective study显示文摘 | Smilovic J Bilic R | 2003 | Croat Med J2003，44，6： | 1 |
| 16 | Levamisole mucosal adjuvant activity for a live attenuated Escherichia coli oral vaccine in weaned pigs 显示文摘 | Bozic F Bilic V Valpotic I | 2003 | Vet Pharmaeal Therap2003，26，： | 1 |
| 17 | Stiff person syndrome (Moersch-Woltman) 显示文摘 | Cerimagic D Bilic E | 2010 | Lijec Vjesn2010，132，34： | 1 |
| 18 | A prospective observationalstudy of 363 cases operated with three different harmonicscalpels显示文摘 | Prgomet D Janjanin S Bilic M | 2009 | Eur Arch Otorhinolaryngol2009，266，12： | 1 |
| 19 | Erythropoiesis and globin switching in compound Klfl :Bcll la mutant mice 显示文摘 | ESTEGHAMAT F GILLEMANS N BILIC I | 2013 | Blood2013，121，13： | 1 |
| 20 | The role of BTB domain-contain/ng zinc fin- ger proteins in T cell development and function显示文摘 | Bilic I Ellmeier W | 2007 | Immunol Lett2007，108，1： | 1 |
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