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| 1 | 中医药调控Wnt/β-catenin信号通路防治肝纤维化的研究进展显示文摘肝纤维化是多种肝脏慢性疾病的共同病理过程,且被认为是肝硬化、肝癌的必经阶段,因此,抗肝纤维化治疗对患者的预后具有重要的现实意义。Wnt/β-catenin信号通路是调控许多肝脏疾病的关键信号通路之一,可通过调控炎症反应、细胞凋亡、氧化应激干预肝纤维化的进程,而靶向干预该通路,如DDK1、Niclosamide、ICG-001、PRI-724、PSH等拮抗剂的长期有效性和负面作用尚未证实。大量研究表明中医药在抗肝纤维化的地位日益受到关注。基于肝纤维化虚实夹杂的中医病因病机,中药以补虚、解毒、化瘀和标本兼治等治法多靶点、多层次调节Wnt/β-catenin信号通路发挥肝保护作用。本文就Wnt/β-catenin通路与肝纤维化的关系阐述中医药延缓肝纤维化的潜在作用,以期为防治肝纤维化提供策略。 | 宋艺佳 周铖 赵文霞 刘鸣昊 | 2023 | 中医药学报2023，51，7： | 0 |
| 2 | Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity显示文摘Liver fibrosis is a reversible pathological process caused by chronic liver damage and a major risk factor for hepatocellular carcinoma(HCC).Hepatic stellate cell(HSC)activation is considered the main target for liver fibrosis therapy.However,the efficiency of this strategy is limited due to the complex microenvironment of liver fibrosis,including excessive extracellular matrix(ECM)deposition and hypoxia-induced imbalanced ECM metabolism.Herein,nilotinib(NIL)-loaded hyaluronic acid(HA)-coated Ag@Pt nanotriangular nanozymes(APNH NTs)were developed to inhibit HSCs activation and remodel the microenvironment of liver fibrosis.APNH NTs efficiently eliminated intrahepatic reactive oxygen species(ROS)due to their inherent superoxide dismutase(SOD)and catalase(CAT)activities,thereby downregulating the expression of NADPH oxidase-4(NOX-4)and inhibiting HSCs activation.Simultaneously,the oxygen produced by the APNH NTs further alleviated the hypoxic microenvironment.Importantly,the released NIL promoted collagen depletion by suppressing the expression of tissue inhibitor of metalloproteinase-1(TIMP-1),thus synergistically remodeling the microenvironment of liver fibrosis.Notably,an in vivo study in CCl_(4)-induced mice revealed that APNH NTs exhibited significant antifibrogenic effects without obvious long-term toxicity.Taken together,the data from this work suggest that treatment with the synthesized APNH NTs provides an enlightening strategy for remodeling the microenvironment of liver fibrosis with boosted antifibrogenic activity. | Huaqing Jing Yingzi Ren Yue Zhou Min Xu Sona Krizkova Zbynek Heger Qiang Lu Siyu Wang Xiaoyang Liang Vojtech Adam Nan Li | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
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