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| 1 | Relating Cd2+binding by humic acids to molecular weight:A modeling and spectroscopic study显示文摘Molecular weight(Mw) is a fundamental property of humic acids(HAs), which considerably affect the mobility and speciation of heavy metals in the environment. In this study, soil humic acid(HA) extracted from Jinyun Mountain, Chongqing was ultra-filtered into four fractions according to the molecular weight, and their properties were characterized.Complexation of cadmium was investigated by titration experiments. For the first time,Langmuir and non-ideal competitive adsorption-Donna(NICA-Donnan) models combined with fluorescence excitation-emission matrix(EEM) quenching were employed to elucidate the binding characteristics of individual Mw fractions of HA. The results showed that the concentration of acidic functional groups decreased with increasing Mw, especially the phenolic groups. The humification degree and aliphaticity increased with increasing Mw as indicated by elemental composition analysis and FT-IR spectra. The binding capacity of Cd^(2+) to Mw fractions of HA followed the order UF1(< 5 kDa) > UF2(5–10 kDa) > UF4(> 30 kDa) > UF3(10–30 kDa). Moreover, the distribution of cadmium speciation indicated that the phenolic groups were responsible for the variations in binding of Cd^(2+) among different Mw fractions. The results of fluorescence quenching illustrated that the binding capacity of Cd^(2+) to Mw fractions was controlled by the content of functional groups, while the binding affinity was largely influenced by structural factors. The results provide a better understanding of the roles that different HA Mw fractions play in heavy metal binding,which has important implications in the control of heavy metal migration and bio-toxicity. | Hongcheng Bai Zhenmao Jiang Minjin He Biying Ye Shiqiang Wei | 2018 | Journal of Environmental Sciences2018，30，8： | 7 |
| 2 | Structural requirements and interaction mechanisms of ACE inhibitory peptides:molecular simulation and thermodynamics studies on LAPYK and its modifi ed peptides显示文摘The understanding of the structural requirements and the intermolecular-interaction mechanism are important for discovering potent angiotensin-converting enzyme(ACE)inhibitory peptides.In this study,we modifi ed an egg-white derived peptide,LAPYK,using the amino acids with different properties to produce the LAPYK-modified peptides.The ACE inhibitory activities of the modified peptides were determined to explore the structural requirements of ACE inhibitory peptides(ACEIPs).Molecular simulation and isothermal titration calorimetry analysis were used to investigate interactions between the peptides and ACE.We found that hydrophobicity and the amino acids with ring structures were benefi cial for the ACE inhibitory activities of the peptides.The results of the molecular mechanics poisson boltzmann surface area(MMPBSA)binding free energy calculations indicated that the polar solvation free energy(ΔG_(polar))of the charged peptides(LAPYK,LAPYE)were unfavorable for binding to ACE.On the other hand,the results of isothermal titration calorimetry analyses suggested that the enthalpy-driven ACE-peptide interactions were more favorable than the entropy-driven ACE-peptide interaction counterparts. | Biying Zhang Jingbo Liu Hedi Wen Feng Jiang Erlei Wang Ting Zhang | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 3 | RNA Methylome Reveals the m^(6)A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering显示文摘The epitranscriptomic mark N6-methyladenosine(m^(6)A),which is the predominant internal modification in RNA,is important for plant responses to diverse stresses.Multiple environmental stresses caused by the tea-withering process can greatly influence the accumulation of specialized metabolites and the formation of tea flavor.However,the effects of the m^(6)A-mediated regulatory mechanism on flavor-related metabolic pathways in tea leaves remain relatively uncharacterized.We performed an integrated RNA methylome and transcriptome analysis to explore the m^(6)Amediated regulatory mechanism and its effects on flavonoid and terpenoid metabolism in tea(Camellia sinensis)leaves under solar-withering conditions.Dynamic changes in global m^(6)A level in tea leaves were mainly controlled by two m^(6)A erasers(CsALKBH4A and CsALKBH4B)during solar-withering treatments.Differentially methylated peak-associated genes following solarwithering treatments with different shading rates were assigned to terpenoid biosynthesis and spliceosome pathways.Further analyses indicated that CsALKBH4-driven RNA demethylation can directly affect the accumulation of volatile terpenoids by mediating the stability and abundance of terpenoid biosynthesis-related transcripts and also indirectly influence the flavonoid,catechin,and theaflavin contents by triggering alternative splicing-mediated regulation.Our findings revealed a novel layer of epitranscriptomic gene regulation in tea flavor-related metabolic pathways and established a link between the m^(6)A-mediated regulatory mechanism and the formation of tea flavor under solar-withering conditions. | Chen Zhu Shuting Zhang Chengzhe Zhou Caiyun Tian Biying Shi Kai Xu Linjie Huang Yun Sun Yuling Lin Zhongxiong Lai Yuqiong Guo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 2 |
| 4 | Compositional differences among planktonic ciliate communities in four subtropical eutrophic lakes in China显示文摘 | Jing Li Feizhou Chen Zhengwen Liu Kuidong Xu Biying Zhao | 2013 | Limnology2013，，1： | 1 |
| 5 | Calculating with pointers 显示文摘 | Bii | 1989 | Science of Computer Programming1989，12，1： | 1 |
| 6 | Education of young Chinese migrant children:challenges and prospects显示文摘 | Biying Hu Judit Szente | | 0，，： | 1 |
| 7 | Designand Analysis of Ultra-Wideband Split Transmit Virtu-al Aperture Array for Trough-the-Wall Imaging显示文摘 | LU Biying ZHAO Yang SUN Xin | 2013 | International Journal of Antennas and Propagation2013，2013，1： | 1 |
| 8 | Eftect of maternal body mass index on pregnancy outcome and newborn weight显示文摘 | Yazdalli S Yosoflliyapasha Y Nasab BII | 2012 | BMC Res Notes2012，5，1： | 1 |
| 9 | Electrochemical Cycl ing Induced Spinel Formation in High Charge Capacity Orthorhombic LiMnO2显示文摘 | Young I1 Jang Biying Huang Haifeng Wang | 1999 | J Electrochem Soc1999，146，9： | 1 |
| 10 | Pricing and effort investment for a newsvendor-type product显示文摘 | Yao-Yu Wang Jian-Cai Wang Biying Shou | 2013 | European Journal of Operational Research2013，，2： | 1 |
| 11 | Ul- trasound evaluation of the Cesarean scar: relation between a niche and postmenstrual spotting显示文摘 | Bii de Vaate A] 13rolmann HA van der Voet LF | 2011 | Ultrasound Obstet Oyne col2011，37，1： | 1 |
| 12 | TEM study of electrochemical cycling-induced damage and disorder in LiCoO2 cathodes for rechargeable lithium batteries显示文摘 | Haifeng Wang Young-II Biying Huang | 1992 | J Electrochem Soc1992，146，2： | 1 |
| 13 | The risk of acute pancr eatitis associated with acid-suppressing drugs显示文摘 | Eland IA Alvarez CII Stricker BII | 2000 | Br J Clin Pharmacol2000，49，5： | 1 |
| 14 | Analysis of the residential location choice and household energy consumption behavior by incorporating multiple self-selection effects显示文摘 | Biying Y ZhangJ Fujiwara A | 2012 | Energy Policy2012，46，： | 1 |
| 15 | Focusing in a large F - number optical system 显示文摘 | GUSINOW M A BII EY M E PALMER M A | 1977 | Optical and Quantum Electronics1977，，9： | 1 |
| 16 | Multi - Period Ageney Problems in Portfolio Management 显示文摘 | Chiu Sheen- Bii | 1992 | NTU Menagement Review1992，，3： | 1 |
| 17 | A computer-based medical record system and personal digital assistants to assess and follow patients with respiratory tract infections visiting a rural Kenyan health centre显示文摘 | Diero L Rotich JK Bii J | 2006 | BMC Med hfform Decis Mak2006，6，： | 1 |
| 18 | Structure and Basicity ofγ-Al2O3-Supported MgO and Its Application to Mercaptan Oxidation显示文摘 | Jiang De-en Zhao Biying Xie Youchang | 2001 | Appl Catal A2001，219，12： | 1 |
| 19 | Internal Control Weakness and Information Uncertainty 显示文摘 | BENEISH M D BII LINGS M B HODDER L D | 2007 | Journal of Accounting and Economics2007，，9： | 1 |
| 20 | Predictive significance of the alterations of p16INK4A, p14AKF, p53, and proliferating cell nuclearantigen expression in the progression of cervical cancer显示文摘 | WANG Jianliu ZHENG Biying LI Xidan | 2004 | Clin Cancer Kes2004，10，7： | 1 |
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