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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Diminished lung function, RSV infection, and respiratory morbidity in prematurely born infants 显示文摘 | Broughton S Bhat R Roberts A | 2006 | Arch Dis Child2006，91，1： | 1 |
| 3 | Adhesion of cellulolytic ruminat bacteria to barley straw 显示文摘 | Bhat S Watlace R J Orskov E R | 1990 | Appl Environ Mierobiol1990，56，： | 1 |
| 4 | Acoustic emission characterization of failure modes in composites with ANN显示文摘 | C Bhat M R Bhat | 2003 | Composite Structures2003，61，： | 1 |
| 5 | Mycotoxins in Food and Feed: Present Status and Future Concerns显示文摘 | Bhat R Rai RV and Karim AA | 2010 | Comprehensive Reviews in Food Science and Food Safety2010，9，1： | 1 |
| 6 | Cerebrospinal fluid lactate dehydrogenase and glutamine in meningitis显示文摘 | Nayak BS Bhat R | | 0，，： | 1 |
| 7 | Bacillus subtilis natto:a non-toxic source of poly-γ-glutamic acid that could be used as a cryoprotectant for probiotic bacteria显示文摘 | BHAT A R IRORERE V U BARTLETT T | 2013 | AMB Express2013，3，1： | 1 |
| 8 | Chemotherapy of fungus infections:Part II-Aliphatic& aromatic acid hydra zones and alkyl or aryl thiosemicarbazones of 5-chloro salicylaldehyde显示文摘 | Bhat AK Bhamaria R P Bellare RA | 1967 | Indian J Chem1967，5，： | 1 |
| 9 | Online estimation of stator resistance of an induction motor for speed control applications 显示文摘 | UMANAND L BHAT S R | 1995 | IEEE Proceeding on Electric Power Applications1995，142，2： | 1 |
| 10 | Lead salt of 2,4 N-trinitroanilinoacetic acid-an energetic bullistic modifier for double base propellants 显示文摘 | Soman R R Mukundan T Bhat V K | 2000 | Journal of Energetic Materials2000，，18： | 1 |
| 11 | Regulation andlocalization of tyrosine216 phosphorylation of glycogen synthasekinase-3 p in cellular and animal models of neuronal degeneration显示文摘 | Bhat R V Shanley J Correll M P | 2000 | Proc Natl Acad Sci USA2000，97，11： | 1 |
| 12 | Commuter Bicyclist Route Choice: Analysis Using a Stated Preference Survey显示文摘 | Stinson M A Bhat C R | 2003 | Transportation Research Record: Journal of the Transportation Research Board2003，1828，： | 1 |
| 13 | Bra~/ca and its close allies: cytogenetics and evolution 显示文摘 | Prakash S Bhat S R Qniros C F | 2009 | Plant Breeding Reviews2009，31，： | 1 |
| 14 | Closed-loop supplychain models with product manufacturing 显示文摘 | Savaskan R C Bhat T S Wassenhove L N V | 2004 | ManagementScience2004，50，2： | 1 |
| 15 | Work travel mode choice and number of non-work commute stops 显示文摘 | Bhat C R | 1997 | Transportation Research Part B1997，31，1： | 1 |
| 16 | Why is trehalose an excep tional P rotein stabi21izer显示文摘 | Kaushik J K Bhat R | 2003 | The Journal of Biological Chemistry2003，278，26： | 1 |
| 17 | Host Range Specificity in Verti-cillium dahliae显示文摘 | Bhat R G Subbarao K V | 1999 | Phytopathology1999，89，： | 1 |
| 18 | Electrospinningof nanofibers显示文摘 | SUBBIAH T BHAT G S TOCK R W | 2005 | Journal of Applied Polymer Science2005，96，2： | 1 |
| 19 | A Multiple Discrete - continuous Extreme Value Model: Formulation and Application to Discretionary Time-use Decisions 显示文摘 | Bhat C R | 2005 | Transportation Research Part B2005，39，8： | 1 |
| 20 | Why is trehalose an exceptional protein stabi- lizer? An analysis of the thermal stability of proteins in the presence of the compatible osmolyte trehalose显示文摘 | KAUSHIK J K BHAT R | 2003 | J Biol Chem2003，278，26： | 1 |
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