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| 1 | 高级别胶质瘤放、化疗耐药性可能与microRNAs相关(英文)显示文摘High-grade gliomas(HGGs) are malignant primary brain tumors of glial cell origin.Despite optimal course of treatment,including maximal surgical resection followed by adjuvant chemo-and/or radiotherapy,the prognosis still remains poor.The main reason is the commonly occurring chemo-and radioresistance of these tumors.In recent years,several signaling pathways,especially PI3K/AKT and ATM/CHK2/p53,have been linked to the resistance of gliomas.Moreover,additional studies have shown that these pathways are significantly regulated by microRNAs(miRNAs),short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis,proliferation,cell cycle,invasivity,and angiogenesis.MiRNAs are not only highly deregulated in gliomas,their expression signatures have also been shown to predict prognosis and therapy response.Therefore,they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients.In this review,we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo-and radiotherapy. | Besse A Sana J Fadrus P Slaby O | 2013 | 中华神经外科疾病研究杂志2013，12，2： | 3 |
| 2 | General self- imaging properties in NxN multimode interference couplers including phase relations显示文摘 | BACHMANN M BESSE P A MEICHIOR H | 1994 | Applied Optics1994，33，18： | 1 |
| 3 | Assessing genetic diversity in a sugarcane germplasm collection using an automated AFLP analysis 显示文摘 | Besse P Taylor G Carroll B | 1998 | Genetica1998，104，： | 1 |
| 4 | Leadership ambiguity and K-12 schools and the limits of contemporary leadership theory显示文摘 | Bess JL Goldman P | | 0，，04： | 1 |
| 5 | A Supported Employment Experience in Western Switzerland for Persons with Mental Health Disorders显示文摘 | Dutoit M Besse C Hausmann P | 2014 | Rev Med Suisse2014，10，442： | 1 |
| 6 | Tracking system with five degrees of freedom using a 2d-array of hall sensors and a permanent magnet显示文摘 | Schlageter V Besse P A Popovic R S | 2001 | Sensors and Actuators A-Physical2001，92，13： | 1 |
| 7 | Genetic diversity among wild and cultivated populations of Hevea brasiliensls assessed by nuclear RFLP analysis显示文摘 | Besse P Seguin M Lebrun P | 1994 | Theor Appl Genet1994，88，2： | 1 |
| 8 | Chemical and Biological Synthesis of Chiral Epoxides 显示文摘 | BESSE P VESCHAMBRE H | 1994 | Tetrahedron1994，50，： | 1 |
| 9 | Polymer interleaved layered double hydroxide: A new emerging class of nanocomposites 显示文摘 | Leroux F Besse J P | 2001 | Chemistry of Materials2001，13，： | 1 |
| 10 | Combined paleomagnetic and isotopic data from the Doushantuo carbonate, South China: implication for the ' snowball Earth' hypothesis显示文摘 | MACOUIN M BESSE J ADER M GILDER S YANG Z SUN Z AGRINIER P | 2004 | Earth and Planetary Science Letters2004，224，： | 1 |
| 11 | The future of magnetic sensors 显示文摘 | Popovie R S Flanagan J A Besse P A | 1996 | Sensors Actuators A1996，56，： | 1 |
| 12 | Delamination of layered double hydroxides by use of surfactants显示文摘 | Adaehi-Pagano M Forano C Besse J P | 2000 | Chem Commun2000，9192，： | 1 |
| 13 | The Future of Magnetic Sensors显示文摘 | Popovic R S Flanagan J A Besse P A | 1996 | Sensors and Actuators A1996，56，12： | 1 |
| 14 | Ribosomal DNA variations in Erianthus, a wild sugarcane relative (Andropogoneae - Saccharinae) 显示文摘 | Besse P McIntyre C L Berding N | 1996 | Theor Appl Genet1996，92，： | 1 |
| 15 | Biopolymer immobilization during the crystalline growth of layered double hydroxide显示文摘 | FABRICE L JULIEN G BESSE J P | 2004 | J Solid State Chem2004，177，： | 1 |
| 16 | Hybrid derivatives of layered double hydroxides 显示文摘 | Prevot V Forano C Besse J P | 2001 | Applied Clay Science2001，18，12： | 1 |
| 17 | LOs complications des hysterectomies 显示文摘 | Lopes P Besse O Laurent FX | 1994 | Ref Gynecol Obstet1994，17，2： | 1 |
| 18 | DNA fingerprints in Hevea brasiliensis (rubber tree)using human minisatellite probes 显示文摘 | BESSE P LEBRUN P SEGUIN M | 1993 | Heredity1993，70，3： | 1 |
| 19 | Stereoselective chemoenzymatic synthesis of both enantiomers of protected 4-amino-2-pentanone显示文摘 | Besse P Ciblat S Canet J L | 1999 | Tetrahedron: Asymmetry1999，10，： | 1 |
| 20 | Principal components analysis of sampled functions显示文摘 | Besse P Ramsay J O | 1986 | Psychometrika1986，51，： | 1 |
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